| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $3,871,237 | - | 477 | - | $8,115 | $3,871,237 | 1 | Warner Bros. | true | false |
| 2 | 1 | Ex | $2,874,947 | -38.1% | 571 | - | $5,034 | $9,035,305 | 2 | 01 Distribution | false | false |
| 3 | - | Questo piccolo grande amore | $2,390,117 | - | 467 | - | $5,118 | $2,842,002 | 1 | Medusa Distribuzione | true | false |
| 4 | - | Friday the 13th | $830,400 | - | 198 | - | $4,193 | $830,400 | 1 | Universal Pictures International (UPI) | true | false |
| 5 | 2 | Italians | $613,709 | -64.5% | 241 | -196 | $2,546 | $15,138,492 | 4 | Filmauro | false | false |
| 6 | 3 | Valkyrie | $567,071 | -60.8% | 241 | -137 | $2,352 | $5,280,076 | 3 | 01 Distribution | false | false |
| 7 | 5 | Journey to the Center of the Earth | $454,848 | -54% | 142 | -74 | $3,203 | $9,562,903 | 5 | 01 Distribution | false | false |
| 8 | 4 | Revolutionary Road | $440,379 | -59.8% | 206 | -73 | $2,137 | $3,989,747 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | 7 | Doubt | $251,686 | -52.3% | 145 | -10 | $1,735 | $1,886,256 | 3 | Walt Disney Pictures | false | false |
| 10 | 10 | Space Chimps | $164,419 | -57.7% | 157 | -26 | $1,047 | $605,747 | 2 | Medusa Distribuzione | false | false |
| 11 | 6 | Horsemen | $157,638 | -70.9% | 114 | -34 | $1,382 | $868,812 | 2 | Moviemax | false | false |
| 12 | 8 | Beverly Hills Chihuahua | $144,828 | -65.1% | 144 | -68 | $1,005 | $4,833,191 | 5 | Walt Disney Pictures | false | false |
| 13 | 12 | Milk | $143,374 | -59.2% | 67 | -51 | $2,139 | $2,558,714 | 4 | BIM Distribuzione | false | false |
| 14 | 11 | Frost/Nixon | $137,940 | -62.7% | 127 | -24 | $1,086 | $655,778 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | 16 | I've Loved You So Long | $113,354 | -22.2% | 54 | +7 | $2,099 | $309,700 | 2 | Mikado Film | false | false |
| 16 | 15 | Slumdog Millionaire | $103,894 | -41.4% | 46 | -16 | $2,258 | $4,188,718 | 11 | Lucky Red | false | false |
| 17 | 9 | Yes Man | $94,473 | -76.4% | 39 | -87 | $2,422 | $10,278,827 | 6 | Warner Bros. | false | false |
| 18 | 17 | Easy Virtue | $62,074 | -41.9% | 26 | -13 | $2,387 | $2,959,136 | 6 | Eagle Pictures | false | false |
| 19 | 14 | Australia | $55,383 | -76.9% | 31 | -91 | $1,786 | $6,488,991 | 5 | 20th Century Fox International | false | false |
| 20 | - | Religulous | $36,692 | - | 22 | - | $1,667 | $36,692 | 1 | Eagle Pictures | true | false |
| 21 | 20 | Empties | $32,065 | -11.9% | 18 | +4 | $1,781 | $292,864 | 5 | Fandango | false | false |
| 22 | 13 | Seven Pounds | $28,331 | -89.5% | 16 | -118 | $1,770 | $14,424,793 | 6 | Sony Pictures Releasing | false | false |
| 23 | 18 | Waltz with Bashir | $28,079 | -48.5% | 20 | -9 | $1,403 | $887,895 | 6 | Lucky Red | false | false |
| 24 | 19 | Home | $20,585 | -47.5% | 17 | +3 | $1,210 | $133,066 | 3 | Teodora Film | false | false |
| 25 | 24 | The Visitor | $16,219 | -34.7% | 8 | -6 | $2,027 | $1,802,952 | 11 | Bolero Film | false | false |
| 26 | 21 | Lemon Tree | $15,903 | -55.5% | 9 | -7 | $1,767 | $1,295,298 | 10 | Teodora Film | false | false |
| 27 | 26 | Mar nero | $14,191 | -33.4% | 7 | +1 | $2,027 | $60,390 | 3 | N/A | false | false |
| 28 | 47 | Beket | $12,564 | +2,167.9% | 2 | +1 | $6,282 | $3,983 | 4 | N/A | false | false |
| 29 | - | Nick and Norah's Infinite Playlist | $11,539 | - | 11 | - | $1,049 | $11,539 | 1 | Sony Pictures Releasing | true | false |
| 30 | - | Katyn | $10,032 | - | 8 | - | $1,254 | $10,032 | 1 | N/A | true | false |
| 31 | 27 | Appaloosa | $8,681 | -58.3% | 6 | -6 | $1,446 | $335,915 | 5 | 01 Distribution | false | false |
| 32 | 22 | The Boy in the Striped Pajamas | $6,716 | -80.3% | 10 | -28 | $671 | $3,303,708 | 9 | Walt Disney Pictures | false | false |
| 33 | - | Le premier cri | $5,669 | - | 10 | - | $566 | $5,669 | 1 | Lucky Red | true | false |
| 34 | 25 | Madagascar: Escape 2 Africa | $4,762 | -80.8% | 14 | -8 | $340 | $32,239,468 | 9 | Universal Pictures International (UPI) | false | false |
| 35 | 28 | We Can Do That | $4,653 | -53.6% | 5 | -2 | $930 | $2,371,846 | 16 | Warner Bros. | false | false |
| 36 | - | The Pursuit of Happyness | $4,214 | - | 1 | - | $4,214 | $21,309,984 | 110 | Medusa Distribuzione | false | false |
| 37 | 36 | Tony Manero | $3,656 | -2% | 6 | +1 | $609 | $167,328 | 5 | Ripley's Film | false | false |
| 38 | 33 | Stella | $3,406 | -33.5% | 3 | -1 | $1,135 | $491,218 | 11 | Sacher Distribuzione | false | false |
| 39 | 35 | Bolt | $2,624 | -37.6% | 7 | +2 | $374 | $7,143,199 | 12 | Walt Disney Pictures | false | false |
| 40 | - | The Hanging Garden | $2,481 | - | 1 | - | $2,481 | $23,871 | - | Mikado Film | - | false |
| 41 | 37 | Let the Right One In | $2,349 | -12.4% | 2 | -1 | $1,174 | $645,369 | 6 | Bolero Film | false | false |
| 42 | 40 | WALL·E | $2,343 | +61.7% | 6 | +4 | $390 | $12,206,783 | 18 | Walt Disney Pictures | false | false |
| 43 | 38 | Welcome to the Sticks | $1,603 | -33.9% | 1 | -1 | $1,603 | $4,245,593 | 16 | Medusa Distribuzione | false | false |
| 44 | 23 | Defiance | $1,056 | -96.7% | 5 | -29 | $211 | $1,144,607 | 4 | Medusa Distribuzione | false | false |
| 45 | 39 | Il sol dell'avvenire | $984 | -53.5% | 2 | - | $492 | $7,105 | 12 | - | false | false |
| 46 | - | The Duchess | $937 | - | 1 | - | $937 | $2,889,399 | 8 | BIM Distribuzione | false | false |
| 47 | - | Nient'altro che noi | $917 | - | 1 | - | $917 | $2,870 | 2 | N/A | false | false |
| 48 | - | Happy-Go-Lucky | $809 | - | 1 | - | $809 | $1,214,552 | 11 | Mikado Film | false | false |
| 49 | - | August Rush | $714 | - | 2 | - | $357 | $1,731,499 | 64 | Medusa Distribuzione | false | false |
| 50 | - | The Class | $661 | - | 1 | - | $661 | $2,223,910 | 19 | Mikado Film | false | false |
| 51 | 31 | Quarantine | $193 | -96.7% | 1 | -4 | $193 | $57,387 | 3 | Sony Pictures Releasing | false | false |
