| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Ex | $4,645,796 | - | 571 | - | $8,136 | $4,647,339 | 1 | 01 Distribution | true | false |
| 2 | 1 | Italians | $1,730,267 | -52% | 437 | -172 | $3,959 | $14,238,807 | 3 | Filmauro | false | false |
| 3 | 2 | Valkyrie | $1,446,388 | -31.1% | 378 | -16 | $3,826 | $4,334,559 | 2 | 01 Distribution | false | false |
| 4 | 3 | Revolutionary Road | $1,094,258 | -31% | 279 | -2 | $3,922 | $3,252,800 | 2 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Journey to the Center of the Earth | $988,134 | -30.8% | 216 | -42 | $4,574 | $8,963,022 | 4 | 01 Distribution | false | false |
| 6 | - | Horsemen | $542,317 | - | 148 | - | $3,664 | $542,317 | 1 | Moviemax | true | false |
| 7 | 9 | Doubt | $527,240 | -19.6% | 155 | +2 | $3,401 | $1,463,123 | 2 | Walt Disney Pictures | false | false |
| 8 | 6 | Beverly Hills Chihuahua | $414,716 | -41.9% | 212 | -29 | $1,956 | $4,654,171 | 4 | Walt Disney Pictures | false | false |
| 9 | 5 | Yes Man | $399,554 | -45.8% | 126 | -77 | $3,171 | $10,151,540 | 5 | Warner Bros. | false | false |
| 10 | - | Space Chimps | $388,415 | - | 183 | - | $2,122 | $388,415 | 1 | Medusa Distribuzione | true | false |
| 11 | - | Frost/Nixon | $369,775 | - | 151 | - | $2,448 | $369,775 | 1 | Universal Pictures International (UPI) | true | false |
| 12 | 10 | Milk | $351,836 | -39.2% | 118 | -56 | $2,981 | $2,300,793 | 3 | BIM Distribuzione | false | false |
| 13 | 7 | Seven Pounds | $270,695 | -61.4% | 134 | -109 | $2,020 | $14,402,221 | 5 | Sony Pictures Releasing | false | false |
| 14 | 8 | Australia | $239,814 | -64.5% | 122 | -145 | $1,965 | $6,402,968 | 4 | 20th Century Fox International | false | false |
| 15 | 11 | Slumdog Millionaire | $177,402 | -26.3% | 62 | -15 | $2,861 | $4,023,362 | 10 | Lucky Red | false | false |
| 16 | - | I've Loved You So Long | $145,611 | - | 47 | - | $3,098 | $146,088 | 1 | Mikado Film | true | false |
| 17 | 13 | Easy Virtue | $106,782 | -46% | 39 | -38 | $2,738 | $294,652 | 5 | Eagle Pictures | false | false |
| 18 | 16 | Waltz with Bashir | $54,514 | -30.9% | 29 | -7 | $1,879 | $839,844 | 5 | Lucky Red | false | false |
| 19 | 23 | Home | $39,217 | +25.5% | 14 | +5 | $2,801 | $96,296 | 2 | Teodora Film | false | false |
| 20 | 19 | Empties | $36,410 | -30.7% | 14 | -9 | $2,600 | $248,274 | 4 | Fandango | false | false |
| 21 | 20 | Lemon Tree | $35,743 | -17.1% | 16 | -4 | $2,233 | $1,270,739 | 9 | Teodora Film | false | false |
| 22 | 17 | The Boy in the Striped Pajamas | $34,131 | -44.1% | 38 | -12 | $898 | $3,262,963 | 8 | Walt Disney Pictures | false | false |
| 23 | 12 | Defiance | $32,414 | -86.1% | 34 | -121 | $953 | $1,139,864 | 3 | Medusa Distribuzione | false | false |
| 24 | 21 | The Visitor | $24,849 | -42.2% | 14 | -4 | $1,774 | $1,779,865 | 10 | Bolero Film | false | false |
| 25 | 18 | Madagascar: Escape 2 Africa | $24,838 | -55% | 22 | -41 | $1,129 | $32,430,274 | 8 | Universal Pictures International (UPI) | false | false |
| 26 | 26 | Mar nero | $21,321 | +85% | 6 | +2 | $3,553 | $37,247 | 2 | N/A | false | false |
| 27 | 24 | Appaloosa | $20,838 | -25% | 12 | +2 | $1,736 | $321,666 | 4 | 01 Distribution | false | false |
| 28 | 27 | We Can Do That | $10,018 | -11.2% | 7 | -1 | $1,431 | $2,374,241 | 15 | Warner Bros. | false | false |
| 29 | 14 | Whisper | $9,556 | -90.6% | 11 | -49 | $868 | $502,464 | 3 | Eagle Pictures | false | false |
| 30 | 15 | Four Christmases | $7,418 | -91% | 8 | -67 | $927 | $526,291 | 3 | Warner Bros. | false | false |
| 31 | 22 | Quarantine | $5,876 | -86.1% | 5 | -5 | $1,175 | $55,882 | 2 | Sony Pictures Releasing | false | false |
| 32 | - | Márió, a varázsló | $5,770 | - | 4 | - | $1,442 | $98,167 | 11 | L'Altrofilm | false | false |
| 33 | 28 | Stella | $5,124 | -53.3% | 4 | -4 | $1,281 | $482,442 | 10 | Sacher Distribuzione | false | false |
| 34 | - | Nim's Island | $4,571 | - | 2 | - | $2,285 | $4,095,643 | 44 | Moviemax | false | false |
| 35 | 32 | Bolt | $4,204 | -15.8% | 5 | -9 | $840 | $6,799,402 | 11 | Walt Disney Pictures | false | false |
| 36 | 25 | Tony Manero | $3,729 | -80.2% | 5 | -7 | $745 | $162,697 | 4 | Ripley's Film | false | false |
| 37 | 31 | Let the Right One In | $2,680 | -57.2% | 3 | -3 | $893 | $644,415 | 5 | Bolero Film | false | false |
| 38 | 36 | Welcome to the Sticks | $2,424 | +23.5% | 2 | +1 | $1,212 | $4,241,300 | 15 | Medusa Distribuzione | false | false |
| 39 | - | Il sol dell'avvenire | $2,114 | - | 2 | - | $1,057 | $5,170 | 11 | - | false | false |
| 40 | 46 | WALL·E | $1,449 | +32.8% | 2 | +1 | $724 | $12,202,410 | 17 | Walt Disney Pictures | false | false |
| 41 | - | Kung Fu Panda | $1,220 | - | 2 | - | $610 | $22,037,818 | 24 | Universal Pictures International (UPI) | false | false |
| 42 | - | Hotel Meina | $949 | - | 1 | - | $949 | $116,536 | 55 | Mikado Film | false | false |
| 43 | - | Mary | $810 | - | 1 | - | $810 | $193,022 | 170 | Mikado Film | false | false |
| 44 | 33 | Lissi und der wilde Kaiser | $689 | -75.1% | 3 | -9 | $229 | $610,399 | 6 | Moviemax | false | false |
| 45 | - | The Fox and the Child | $652 | - | 1 | - | $652 | $2,400,103 | 47 | Lucky Red | false | false |
| 46 | 47 | Twilight | $563 | -45.9% | 1 | - | $563 | $16,146,931 | 12 | Eagle Pictures | false | false |
| 47 | 45 | Beket | $554 | -53.5% | 1 | - | $554 | $2,503 | 3 | N/A | false | false |
| 48 | - | Alexandra | $479 | - | 1 | - | $479 | $77,404 | 37 | N/A | false | false |
| 49 | - | Just a Father | $462 | - | 1 | - | $462 | $3,065,931 | 11 | Warner Bros. | false | false |
| 50 | - | Gomorrah | $387 | - | 1 | - | $387 | $17,660,993 | 39 | 01 Distribution | false | false |
