| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $3,271,981 | - | 425 | - | $7,698 | $3,271,981 | 1 | Warner Bros. | true | false |
| 2 | - | He's Just Not That Into You | $2,828,591 | - | 375 | - | $7,542 | $2,828,591 | 1 | Entertainment Film Distributors | true | false |
| 3 | 1 | Slumdog Millionaire | $2,347,109 | -31.6% | 437 | +21 | $5,370 | $24,978,529 | 5 | Pathé | false | false |
| 4 | 2 | Valkyrie | $934,905 | -50.3% | 408 | -47 | $2,291 | $7,848,801 | 3 | 20th Century Fox International | false | false |
| 5 | 3 | Revolutionary Road | $752,337 | -48.8% | 253 | +1 | $2,973 | $3,088,690 | 2 | Paramount Pictures International | false | false |
| 6 | 4 | My Bloody Valentine | $501,769 | -62.6% | 160 | -28 | $3,136 | $8,157,965 | 4 | Lionsgate | false | false |
| 7 | - | The Secret of Moonacre | $455,431 | - | 363 | - | $1,254 | $455,431 | 1 | Warner Bros. | true | false |
| 8 | 8 | Role Models | $437,466 | -54.6% | 248 | -63 | $1,763 | $11,585,456 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Seven Pounds | $402,648 | -62.6% | 286 | -90 | $1,407 | $7,577,278 | 4 | Sony Pictures Releasing | false | false |
| 10 | - | Doubt | $374,127 | - | 145 | - | $2,580 | $374,127 | 1 | Walt Disney Pictures | true | false |
| 11 | - | Vicky Cristina Barcelona | $360,213 | - | 34 | - | $10,594 | $360,213 | 1 | Optimum Releasing | true | false |
| 12 | 5 | Beverly Hills Chihuahua | $354,914 | -67.2% | 371 | -66 | $956 | $4,865,518 | 4 | Walt Disney Pictures | false | false |
| 13 | 7 | Bride Wars | $339,627 | -66.3% | 269 | -111 | $1,262 | $10,167,879 | 5 | 20th Century Fox International | false | false |
| 14 | 9 | Underworld: Rise of the Lycans | $222,441 | -70.7% | 109 | -225 | $2,040 | $3,543,079 | 3 | Entertainment Film Distributors | false | false |
| 15 | 14 | The Reader | $189,110 | -54.2% | 177 | -49 | $1,068 | $6,181,666 | 6 | Entertainment Film Distributors | false | false |
| 16 | - | Punisher: War Zone | $134,602 | - | 195 | - | $690 | $134,602 | 1 | Sony Pictures Releasing | true | false |
| 17 | 11 | Frost/Nixon | $127,861 | -74.2% | 152 | -143 | $841 | $2,298,480 | 3 | Universal Pictures International (UPI) | false | false |
| 18 | 12 | Madagascar: Escape 2 Africa | $121,458 | -73.3% | 204 | -182 | $595 | $33,562,100 | 10 | Paramount Pictures International | false | false |
| 19 | 13 | Bedtime Stories | $112,492 | -73.4% | 193 | -168 | $582 | $12,550,919 | 7 | Walt Disney Pictures | false | false |
| 20 | 10 | Nick and Norah's Infinite Playlist | $110,515 | -81.1% | 199 | -53 | $555 | $951,791 | 2 | Sony Pictures Releasing | false | false |
| 21 | 16 | Milk | $108,769 | -64.2% | 75 | -53 | $1,450 | $1,411,014 | 3 | Momentum Pictures | false | false |
| 22 | - | Twilight | $101,891 | - | 142 | - | $717 | $16,214,241 | 8 | Contender Entertainment Group | false | false |
| 23 | 15 | The Wrestler | $96,378 | -68.9% | 102 | -126 | $944 | $3,273,960 | 4 | Optimum Releasing | false | false |
| 24 | 17 | Yes Man | $54,918 | -75.5% | 69 | -114 | $795 | $15,326,247 | 7 | Warner Bros. | false | false |
| 25 | 19 | Australia | $40,214 | -69.3% | 49 | -54 | $820 | $11,557,128 | 7 | 20th Century Fox International | false | false |
| 26 | 18 | Defiance | $37,154 | -81.9% | 64 | -132 | $580 | $5,492,457 | 5 | Momentum Pictures | false | false |
| 27 | 21 | Sex Drive | $32,953 | -66.3% | 49 | -59 | $672 | $2,297,886 | 5 | Entertainment One | false | false |
| 28 | 22 | Rachel Getting Married | $32,423 | -57.8% | 17 | -8 | $1,907 | $357,895 | 3 | Sony Pictures Releasing | false | false |
| 29 | 24 | The Dark Knight | $31,403 | -33.9% | 12 | -25 | $2,616 | $88,939,810 | 29 | Warner Bros. | false | false |
| 30 | - | The Good the Bad the Weird | $26,551 | - | 14 | - | $1,896 | $26,551 | 1 | Icon Film Distribution Australia | true | false |
| 31 | 20 | Luck by Chance | $24,764 | -76.9% | 23 | -27 | $1,076 | $176,708 | 2 | Adlabs Films | false | false |
| 32 | 29 | Fly Me to the Moon 3D | $17,441 | +2.7% | 3 | - | $5,813 | $2,072,260 | 19 | Momentum Pictures | false | false |
| 33 | - | Naan Kadavul | $16,606 | - | 4 | - | $4,151 | $16,606 | 1 | Ayngaran International | true | false |
| 34 | 26 | Che: Part One | $14,791 | -41.5% | 10 | -26 | $1,479 | $1,793,274 | 6 | Optimum Releasing | false | false |
| 35 | 31 | Igor | $14,772 | -7.4% | 80 | -2 | $184 | $6,654,100 | 18 | Momentum Pictures | false | false |
| 36 | 35 | Changeling | $8,702 | +11.5% | 53 | +40 | $164 | $7,484,903 | 11 | Universal Pictures International (UPI) | false | false |
| 37 | 23 | The Tale of Despereaux | $8,481 | -82.2% | 43 | -61 | $197 | $3,540,452 | 8 | Universal Pictures International (UPI) | false | false |
| 38 | 34 | Barry Lyndon | $8,449 | -4.2% | 1 | - | $8,449 | $22,290 | 2 | British Film Institute (BFI) | false | false |
| 39 | 27 | CC2C | $7,484 | -69.2% | 8 | -22 | $935 | $724,619 | 4 | Warner Bros. | false | false |
| 40 | 33 | City of Ember | $6,922 | -24.4% | 71 | -3 | $97 | $2,161,567 | 18 | Entertainment Film Distributors | false | false |
| 41 | 28 | Raaz: The Mystery Continues | $6,764 | -64.3% | 7 | -3 | $966 | $125,462 | 3 | Tip Top Entertainment (TTE) | false | false |
| 42 | 32 | Waltz with Bashir | $6,019 | -42.9% | 5 | -2 | $1,203 | $997,766 | 12 | Artificial Eye | false | false |
| 43 | 45 | Gomorrah | $4,095 | +15.2% | 4 | -1 | $1,023 | $1,376,551 | 18 | Optimum Releasing | false | false |
| 44 | 37 | Tokyo Sonata | $4,055 | -39% | 3 | - | $1,351 | $13,899 | 2 | Eureka Entertainment | false | false |
| 45 | - | A Bunch of Amateurs 2008 Re-release | $3,740 | - | 5 | - | $748 | $461,140 | - | Entertainment Film Distributors | - | false |
| 46 | 41 | Quantum of Solace | $3,421 | -36.4% | 1 | -1 | $3,421 | $80,264,203 | 15 | Sony Pictures Releasing | false | false |
| 47 | 39 | A Christmas Tale | $3,289 | -40.8% | 4 | - | $822 | $70,829 | 4 | New Wave Films | false | false |
| 48 | 54 | La Bohème | $2,455 | +57.9% | 2 | -1 | $1,227 | $54,953 | 8 | Axiom Films | false | false |
| 49 | 47 | High School Musical 3: Senior Year | $1,758 | -44% | 9 | -2 | $195 | $33,900,140 | 16 | Walt Disney Pictures | false | false |
| 50 | 30 | The Broken | $1,735 | -89.5% | 4 | -4 | $433 | $28,177 | 2 | The Works UK Distribution | false | false |
| 51 | 44 | The Day the Earth Stood Still | $1,515 | -59.1% | 4 | -1 | $378 | $10,846,071 | 9 | 20th Century Fox International | false | false |
| 52 | 65 | Patti Smith: Dream of Life | $1,429 | +435.2% | 1 | - | $1,429 | $27,271 | 10 | Verve Pictures | false | false |
| 53 | 42 | Gonzo | $1,236 | -68.6% | 1 | -5 | $1,236 | $186,575 | 8 | Optimum Releasing | false | false |
| 54 | - | Who Killed Nancy? | $1,119 | - | 1 | - | $1,119 | $1,119 | 1 | Soda Pictures | true | false |
| 55 | 68 | Of Time and the City | $1,001 | +2,680.6% | 2 | +1 | $500 | $361,040 | 15 | British Film Institute (BFI) | false | false |
| 56 | 51 | The Baader Meinhof Complex | $984 | -53.8% | 1 | -1 | $984 | $617,716 | 13 | Momentum Pictures | false | false |
| 57 | 64 | Bicycle Thieves 2008 Re-release | $773 | +143.1% | 1 | - | $773 | $49,610 | 8 | Park Circus | false | false |
| 58 | 58 | Notorious 2008 Re-release | $668 | -25.8% | 1 | - | $668 | $52,500 | 4 | British Film Institute (BFI) | false | false |
| 59 | 56 | Hunger | $572 | -48% | 1 | -16 | $572 | $1,182,387 | 15 | Pathé | false | false |
| 60 | 53 | Dean Spanley 2008 Re-release | $441 | -73.3% | 2 | -1 | $220 | $283,941 | 9 | Icon Film Distribution Australia | false | false |
| 61 | 49 | I've Loved You So Long | $404 | -85.5% | 2 | -1 | $202 | $1,808,400 | 20 | Lionsgate | false | false |
| 62 | 63 | Julia | $346 | +8.8% | 1 | -2 | $346 | $82,846 | 10 | Chelsea Films | false | false |
| 63 | 62 | Lorna's Silence | $225 | -57.7% | 1 | -1 | $225 | $50,989 | 11 | New Wave Films | false | false |
| 64 | 59 | The Spirit | $201 | -77.5% | 3 | - | $67 | $3,225,500 | 6 | Lionsgate | false | false |
| 65 | 69 | Let it Rain | $186 | +541.4% | 1 | - | $186 | $244,816 | 14 | Artificial Eye | false | false |
| 66 | 66 | Rivales | $149 | -39.4% | 1 | - | $149 | $38,358 | 10 | Optimum Releasing | false | false |
| 67 | - | Brideshead Revisited | $30 | - | 1 | - | $30 | $2,115,490 | 19 | Walt Disney Pictures | false | false |
| 68 | 48 | North Face | $30 | -98.9% | 1 | - | $30 | $63,880 | 9 | Metrodome Distribution | false | false |
