| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Curious Case of Benjamin Button | $573,182 | -16.3% | 70 | - | $8,188 | $1,377,405 | 2 | Warner Bros. | false | false |
| 2 | - | Bolt | $452,465 | - | 98 | - | $4,616 | $705,779 | 1 | Walt Disney Pictures | true | false |
| 3 | - | Bride Wars | $259,184 | - | 50 | - | $5,183 | $314,748 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Valkyrie | $251,185 | -31.6% | 75 | - | $3,349 | $1,355,684 | 3 | 20th Century Fox International | false | false |
| 5 | - | Friday the 13th | $169,151 | - | 27 | - | $6,264 | $169,151 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 3 | LOL (Laughing Out Loud) | $163,892 | -1% | 15 | +1 | $10,926 | $353,003 | 2 | Alternative Films | false | false |
| 7 | 7 | Slumdog Millionaire | $137,150 | +1.2% | 24 | +1 | $5,714 | $907,272 | 5 | Cinéart | false | false |
| 8 | - | Doubt | $105,083 | - | 34 | - | $3,090 | $110,161 | 1 | Walt Disney Pictures | true | false |
| 9 | - | The Wrestler | $86,265 | - | 23 | - | $3,750 | $89,136 | 1 | - | true | false |
| 10 | 4 | Revolutionary Road | $79,542 | -44.4% | 40 | -3 | $1,988 | $880,132 | 4 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | De l'autre côté du lit | $76,814 | -28.9% | 28 | - | $2,743 | $1,123,608 | 6 | Belga Films | false | false |
| 12 | 8 | Twilight | $75,327 | -38.9% | 41 | -13 | $1,837 | $3,109,937 | 12 | Belga Films | false | false |
| 13 | 5 | Yes Man | $75,028 | -47.1% | 25 | -10 | $3,001 | $2,061,363 | 7 | Warner Bros. | false | false |
| 14 | 6 | Role Models | $48,940 | -63.9% | 24 | - | $2,039 | $198,716 | 2 | Universal Pictures International (UPI) | false | false |
| 15 | 12 | Loft | $43,116 | -11.2% | 25 | -5 | $1,724 | $9,412,399 | 17 | Independent Films | false | false |
| 16 | 11 | Seven Pounds | $38,934 | -54.3% | 19 | -11 | $2,049 | $887,012 | 5 | Sony Pictures Releasing | false | false |
| 17 | 10 | Madagascar: Escape 2 Africa | $36,807 | -62.3% | 58 | -22 | $634 | $6,243,570 | 11 | Universal Pictures International (UPI) | false | false |
| 18 | - | Le séminaire Caméra Café | $27,016 | - | 15 | - | $1,801 | $27,540 | 1 | Victory Productions | true | false |
| 19 | 14 | Dirty Mind | $25,532 | -38.6% | 16 | -2 | $1,595 | $154,321 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 20 | 17 | Burn After Reading | $16,969 | -35.8% | 11 | -6 | $1,542 | $1,503,255 | 10 | Universal Pictures International (UPI) | false | false |
| 21 | 13 | The Women | $15,089 | -64% | 10 | -7 | $1,508 | $185,561 | 3 | Belga Films | false | false |
| 22 | 19 | The Duchess | $13,276 | -39.8% | 23 | - | $577 | $448,229 | 6 | Cinéart | false | false |
| 23 | - | The Sea Wall | $12,001 | - | 6 | - | $2,000 | $13,773 | 1 | Cinéart | true | false |
| 24 | 15 | Australia | $10,862 | -63.3% | 20 | -20 | $543 | $1,724,503 | 9 | 20th Century Fox International | false | false |
| 25 | - | The Secret of Kells | $9,109 | - | 15 | - | $607 | $9,109 | 1 | Kinepolis Film Distribution (KFD) | true | false |
| 26 | - | Spy of Orange | $8,870 | - | 3 | - | $2,956 | $8,870 | 1 | A-Film Distribution | true | false |
| 27 | 33 | Pride and Glory | $7,616 | +12.9% | 2 | - | $3,808 | $225,551 | 11 | Kinepolis Film Distribution (KFD) | false | false |
| 28 | 23 | Two Lovers | $7,177 | -52.2% | 10 | - | $717 | $459,695 | 8 | Cinéart | false | false |
| 29 | 18 | Trouble at Timpetill | $6,894 | -69.8% | 12 | -3 | $574 | $528,182 | 9 | Alternative Films | false | false |
| 30 | 27 | Frost/Nixon | $5,977 | -35.6% | 6 | -5 | $996 | $135,447 | 5 | Universal Pictures International (UPI) | false | false |
| 31 | 21 | Piet Piraat en het zwaard van Zilvertand | $5,710 | -70.2% | 14 | -10 | $407 | $597,383 | 10 | Kinepolis Film Distribution (KFD) | false | false |
| 32 | 30 | Il Divo | $5,624 | -24.8% | 5 | -1 | $1,124 | $83,537 | 5 | ABC Distribution | false | false |
| 33 | 28 | Private Lessons | $5,082 | -43.6% | 9 | - | $564 | $69,941 | 4 | Cinéart | false | false |
| 34 | 16 | The Flight Before Christmas | $4,511 | -84.8% | 17 | -14 | $265 | $648,822 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 35 | 25 | Eden Lake | $3,836 | -64% | 6 | - | $639 | $83,345 | 4 | Benelux Film Distributors | false | false |
| 36 | 43 | Welcome to the Sticks | $3,664 | +57.7% | 4 | +1 | $916 | $10,711,439 | 51 | Alternative Films | false | false |
| 37 | 31 | Winter in Wartime | $3,601 | -51.7% | 10 | - | $360 | $346,165 | 11 | Benelux Film Distributors | false | false |
| 38 | 20 | Bedtime Stories | $2,665 | -87.1% | 7 | -18 | $380 | $961,701 | 8 | Walt Disney Pictures | false | false |
| 39 | 34 | Changeling | $2,241 | -60.7% | 4 | -1 | $560 | $967,636 | 14 | Universal Pictures International (UPI) | false | false |
| 40 | 35 | The Baader Meinhof Complex | $2,154 | -61.5% | 4 | -2 | $538 | $18,716 | 3 | A-Film Distribution | false | false |
| 41 | 32 | High School Musical 3: Senior Year | $1,819 | -73.5% | 2 | -2 | $909 | $2,848,130 | 16 | Walt Disney Pictures | false | false |
| 42 | 44 | Elite Squad | $1,507 | -1.1% | 2 | - | $753 | $50,995 | 4 | Benelux Film Distributors | false | false |
| 43 | 40 | Stella | $1,454 | -46% | 4 | - | $363 | $24,509 | 5 | Benelux Film Distributors | false | false |
| 44 | 24 | Transporter 3 | $1,314 | -87.9% | 3 | -5 | $438 | $1,284,778 | 10 | Belga Films | false | false |
| 45 | 46 | Elegy | $1,013 | -25.2% | 6 | +2 | $168 | $179,707 | 17 | Kinepolis Film Distribution (KFD) | false | false |
| 46 | 45 | Modern Life | $835 | -40.1% | 2 | - | $417 | $53,119 | 15 | Benelux Film Distributors | false | false |
| 47 | 49 | Moscow, Belgium | $808 | -27% | 2 | +1 | $404 | $1,889,853 | 55 | Kinepolis Film Distribution (KFD) | false | false |
| 48 | 22 | Beauties at War | $756 | -95.7% | 5 | -11 | $151 | $384,471 | 5 | Belga Films | false | false |
| 49 | 37 | Blinker en de blixvaten | $645 | -87.7% | 5 | -6 | $129 | $273,069 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 50 | 29 | Special Correspondents | $627 | -92.7% | 3 | -7 | $209 | $91,333 | 4 | Victory Productions | false | false |
| 51 | 26 | King Guillaume | $523 | -94.9% | 1 | -7 | $523 | $16,390 | 2 | Les Films de l'Elysée | false | false |
| 52 | 47 | Appaloosa | $479 | -58.9% | 2 | -2 | $239 | $88,025 | 6 | Paradiso Entertainment | false | false |
| 53 | 57 | Hunger | $349 | +2.9% | 2 | -1 | $174 | $40,359 | 14 | Paradiso Entertainment | false | false |
| 54 | - | Blind Loves | $315 | - | 1 | - | $315 | $1,128 | 1 | Benelux Film Distributors | true | false |
| 55 | 58 | Religulous | $23 | -89.2% | 1 | -1 | $23 | $5,474 | 4 | A-Film Distribution | false | false |
