| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Yes Man | $488,980 | -1.8% | 60 | - | $8,149 | $1,269,467 | 2 | Warner Bros. | false | false |
| 2 | 2 | Hotel for Dogs | $238,543 | -0.7% | 43 | +1 | $5,547 | $572,600 | 2 | N/A | false | false |
| 3 | 3 | Seven Pounds | $164,312 | -13.9% | 34 | -5 | $4,832 | $882,759 | 3 | N/A | false | false |
| 4 | 4 | Marley & Me | $138,797 | -27.1% | 40 | +2 | $3,469 | $921,142 | 3 | N/A | false | false |
| 5 | - | Revolutionary Road | $62,863 | - | 16 | - | $3,928 | $71,000 | 1 | N/A | true | false |
| 6 | - | Mad Money | $61,936 | - | 15 | - | $4,129 | $64,543 | 1 | N/A | true | false |
| 7 | 6 | Quarantine | $58,078 | -24.7% | 20 | -1 | $2,903 | $177,633 | 2 | N/A | false | false |
| 8 | 7 | Changeling | $50,894 | -19.9% | 22 | -2 | $2,313 | $168,824 | 2 | N/A | false | false |
| 9 | 5 | Twilight | $50,227 | -39.1% | 26 | -7 | $1,931 | $2,675,728 | 7 | N/A | false | false |
| 10 | - | Free Style | $43,042 | - | 19 | - | $2,265 | $43,042 | 1 | N/A | true | false |
| 11 | 8 | Bolt | $41,178 | -34.9% | 32 | -14 | $1,286 | $2,173,173 | 7 | N/A | false | false |
| 12 | - | Lonely Hearts | $35,472 | - | 12 | - | $2,956 | $38,323 | 1 | N/A | true | false |
| 13 | 14 | The Abandoned | $33,449 | +123.3% | 12 | +2 | $2,787 | $306,481 | 4 | N/A | false | false |
| 14 | 11 | The Marsh | $26,895 | +5.6% | 10 | +1 | $2,689 | $264,481 | 4 | N/A | false | false |
| 15 | 9 | Madagascar: Escape 2 Africa | $22,549 | -60.4% | 30 | -20 | $751 | $5,414,705 | 8 | N/A | false | false |
| 16 | 10 | Bangkok Dangerous | $20,139 | -61.9% | 10 | -13 | $2,013 | $311,479 | 3 | N/A | false | false |
| 17 | - | Bella | $9,843 | - | 4 | - | $2,460 | $12,020 | 1 | N/A | true | false |
| 18 | 12 | A mi me gusta | $9,116 | -55.2% | 5 | -8 | $1,823 | $564,490 | 8 | N/A | false | false |
| 19 | 18 | The Tale of Despereaux | $7,306 | -24.2% | 14 | +7 | $521 | $746,615 | 5 | N/A | false | false |
| 20 | 19 | The Boy in the Striped Pajamas | $3,420 | -40.6% | 6 | -1 | $570 | $287,615 | 11 | N/A | false | false |
| 21 | 13 | Burn After Reading | $3,209 | -78.7% | 6 | -9 | $534 | $366,882 | 4 | N/A | false | false |
| 22 | 15 | RocknRolla | $2,300 | -79.9% | 13 | -2 | $176 | $102,308 | 3 | N/A | false | false |
| 23 | 20 | The Day the Earth Stood Still | $562 | -87.3% | 4 | -3 | $140 | $2,353,805 | 8 | N/A | false | false |
| 24 | 16 | Four Christmases | $244 | -97.8% | 4 | -11 | $61 | $1,229,230 | 6 | N/A | false | false |
| 25 | 17 | Australia | $98 | -99.1% | 1 | -3 | $98 | $785,303 | 6 | N/A | false | false |
| 26 | 22 | Max Payne | $67 | -94% | 1 | -2 | $67 | $619,747 | 5 | N/A | false | false |
