| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Italians | $3,605,201 | -41.7% | 609 | -2 | $5,919 | $11,422,196 | 2 | Filmauro | false | false |
| 2 | - | Valkyrie | $2,099,233 | - | 394 | - | $5,328 | $2,099,233 | 1 | 01 Distribution | true | false |
| 3 | - | Revolutionary Road | $1,586,874 | - | 281 | - | $5,647 | $1,586,874 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | Journey to the Center of the Earth | $1,427,962 | -30% | 258 | -15 | $5,534 | $7,551,332 | 3 | 01 Distribution | false | false |
| 5 | 5 | Yes Man | $737,004 | -42.8% | 203 | -58 | $3,630 | $9,454,098 | 4 | Warner Bros. | false | false |
| 6 | 6 | Beverly Hills Chihuahua | $713,364 | -39.2% | 241 | +195 | $2,960 | $4,076,651 | 3 | Walt Disney Pictures | false | false |
| 7 | 3 | Seven Pounds | $702,164 | -55.5% | 243 | -135 | $2,889 | $13,746,893 | 4 | Sony Pictures Releasing | false | false |
| 8 | 4 | Australia | $676,077 | -55.3% | 267 | -178 | $2,532 | $5,883,012 | 3 | 20th Century Fox International | false | false |
| 9 | - | Doubt | $655,553 | - | 153 | - | $4,284 | $655,553 | 1 | Walt Disney Pictures | true | false |
| 10 | 7 | Milk | $578,534 | -26.9% | 174 | +25 | $3,324 | $1,701,073 | 2 | BIM Distribuzione | false | false |
| 11 | 12 | Slumdog Millionaire | $240,871 | +13.9% | 77 | +30 | $3,128 | $3,710,072 | 9 | Lucky Red | false | false |
| 12 | 8 | Defiance | $233,576 | -60.4% | 155 | -33 | $1,506 | $1,012,627 | 2 | Medusa Distribuzione | false | false |
| 13 | 9 | Easy Virtue | $197,626 | -47% | 77 | -33 | $2,566 | $2,688,475 | 4 | Eagle Pictures | false | false |
| 14 | 11 | Whisper | $101,246 | -61.5% | 60 | -13 | $1,687 | $449,392 | 2 | Eagle Pictures | false | false |
| 15 | 10 | Four Christmases | $81,992 | -73.7% | 75 | -48 | $1,093 | $484,093 | 2 | Warner Bros. | false | false |
| 16 | 15 | Waltz with Bashir | $78,878 | -39.4% | 36 | -8 | $2,191 | $740,032 | 4 | Lucky Red | false | false |
| 17 | 16 | The Boy in the Striped Pajamas | $61,050 | -13.7% | 50 | -6 | $1,221 | $3,146,936 | 7 | Walt Disney Pictures | false | false |
| 18 | 13 | Madagascar: Escape 2 Africa | $55,190 | -67.3% | 63 | -36 | $876 | $32,005,574 | 7 | Universal Pictures International (UPI) | false | false |
| 19 | 20 | Empties | $52,547 | +17.9% | 23 | +8 | $2,284 | $188,685 | 3 | Fandango | false | false |
| 20 | 18 | Lemon Tree | $43,100 | -29.9% | 20 | -5 | $2,155 | $1,186,233 | 8 | Teodora Film | false | false |
| 21 | 19 | The Visitor | $43,000 | -16.1% | 18 | - | $2,388 | $1,721,231 | 9 | Bolero Film | false | false |
| 22 | - | Quarantine | $42,255 | - | 10 | - | $4,225 | $42,255 | 1 | Sony Pictures Releasing | true | false |
| 23 | - | Home | $31,251 | - | 9 | - | $3,472 | $41,683 | 1 | Teodora Film | true | false |
| 24 | 17 | Appaloosa | $27,800 | -59.6% | 10 | -19 | $2,780 | $286,903 | 3 | 01 Distribution | false | false |
| 25 | 21 | Tony Manero | $18,811 | -42.2% | 12 | -2 | $1,567 | $148,067 | 3 | Ripley's Film | false | false |
| 26 | - | Mar nero | $11,524 | - | 4 | - | $2,881 | $11,524 | 1 | N/A | true | false |
| 27 | 24 | We Can Do That | $11,287 | -16.4% | 8 | -1 | $1,410 | $2,324,650 | 14 | Warner Bros. | false | false |
| 28 | 23 | Stella | $10,973 | -41.7% | 8 | -2 | $1,371 | $461,894 | 9 | Sacher Distribuzione | false | false |
| 29 | 14 | Imago mortis | $9,914 | -94% | 12 | -84 | $826 | $1,020,042 | 3 | Medusa Distribuzione | false | false |
| 30 | 25 | Happy-Go-Lucky | $7,003 | -42.5% | 7 | +1 | $1,000 | $1,170,471 | 9 | Mikado Film | false | false |
| 31 | 22 | Let the Right One In | $6,268 | -67% | 6 | -4 | $1,044 | $630,879 | 4 | Bolero Film | false | false |
| 32 | 28 | Bolt | $4,992 | -40.5% | 14 | -1 | $356 | $6,727,020 | 10 | Walt Disney Pictures | false | false |
| 33 | 34 | Lissi und der wilde Kaiser | $2,765 | +5.9% | 12 | +1 | $230 | $593,467 | 5 | Moviemax | false | false |
| 34 | 27 | Nights in Rodanthe | $2,605 | -72.8% | 3 | -7 | $868 | $8,805,990 | 7 | Warner Bros. | false | false |
| 35 | - | Natale a Rio | $1,965 | - | 1 | - | $1,965 | $36,125,993 | 7 | Filmauro | false | false |
| 36 | 29 | Welcome to the Sticks | $1,962 | -55.6% | 1 | -2 | $1,962 | $3,943,225 | 14 | Medusa Distribuzione | false | false |
| 37 | 26 | The Duchess | $1,935 | -83.6% | 5 | -6 | $387 | $2,881,030 | 6 | BIM Distribuzione | false | false |
| 38 | - | I Only Wanted to Live | $1,916 | - | 1 | - | $1,916 | $28,847 | 158 | 01 Distribution | false | false |
| 39 | - | The Sea Inside | $1,912 | - | 1 | - | $1,912 | $622,890 | 231 | N/A | false | false |
| 40 | - | Rachel Getting Married | $1,735 | - | 2 | - | $867 | $288,409 | 11 | Sony Pictures Releasing | false | false |
| 41 | - | Changeling | $1,728 | - | 3 | - | $576 | $6,693,283 | 12 | Universal Pictures International (UPI) | false | false |
| 42 | 35 | The Early Bird Catches the Worm | $1,470 | -35.7% | 1 | - | $1,470 | $1,550,893 | 49 | Medusa Distribuzione | false | false |
| 43 | 30 | As God Commands | $1,365 | -68.6% | 4 | - | $341 | $4,496,101 | 8 | 01 Distribution | false | false |
| 44 | - | The Hanging Garden | $1,274 | - | 2 | - | $637 | $22,428 | - | Mikado Film | - | false |
| 45 | 45 | Beket | $1,191 | +92.7% | 1 | - | $1,191 | $1,930 | 2 | N/A | false | false |
| 46 | - | WALL·E | $1,091 | - | 1 | - | $1,091 | $12,200,012 | 16 | Walt Disney Pictures | false | false |
| 47 | 41 | Twilight | $1,040 | -10.9% | 1 | - | $1,040 | $16,145,010 | 11 | Eagle Pictures | false | false |
| 48 | - | Trick or Treaters | $973 | - | 4 | - | $243 | $124,488 | 13 | BIM Distribuzione | false | false |
| 49 | - | The Kite Runner | $854 | - | 1 | - | $854 | $12,730,140 | 45 | Filmauro | false | false |
| 50 | - | The Chronicles of Narnia: Prince Caspian | $835 | - | 1 | - | $835 | $11,791,400 | 25 | Walt Disney Pictures | false | false |
