| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Bolt | $271,714 | -36% | 103 | +10 | $2,638 | $1,639,985 | 3 | Walt Disney Pictures | false | false |
| 2 | 2 | Changeling | $168,509 | -18.1% | 47 | +3 | $3,585 | $471,185 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 4 | Yes Man | $167,242 | -7.1% | 58 | +8 | $2,883 | $809,109 | 3 | Warner Bros. | false | false |
| 4 | - | Inkheart | $157,719 | - | 46 | - | $3,428 | $157,719 | 1 | Distribution Company | true | false |
| 5 | 3 | Marley & Me | $132,924 | -28% | 59 | +3 | $2,252 | $408,918 | 2 | 20th Century Fox International | false | false |
| 6 | - | Revolutionary Road | $113,459 | - | 23 | - | $4,933 | $113,459 | 1 | Paramount Pictures International | true | false |
| 7 | 5 | Twilight | $94,801 | -24.5% | 86 | -2 | $1,102 | $1,750,999 | 5 | Alfa Films | false | false |
| 8 | 8 | Doubt | $67,325 | -18.8% | 30 | +4 | $2,244 | $364,980 | 3 | Walt Disney Pictures | false | false |
| 9 | 6 | The Day the Earth Stood Still | $64,365 | -40.9% | 73 | -16 | $881 | $1,886,078 | 5 | 20th Century Fox International | false | false |
| 10 | 7 | Australia | $62,069 | -29.4% | 64 | +3 | $969 | $705,197 | 4 | 20th Century Fox International | false | false |
| 11 | 9 | Madagascar: Escape 2 Africa | $45,596 | -31.8% | 63 | -18 | $723 | $5,312,568 | 9 | Paramount Pictures International | false | false |
| 12 | 10 | The Spirit | $24,398 | -43.1% | 26 | - | $938 | $86,925 | 2 | Sony Pictures Releasing | false | false |
| 13 | - | Sex Drive | $21,817 | - | 29 | - | $752 | $21,817 | 1 | Alfa Films | true | false |
| 14 | 12 | El ratón Pérez 2 | $14,710 | -27.6% | 51 | -13 | $288 | $705,434 | 5 | Walt Disney Pictures | false | false |
| 15 | 13 | Bangkok Dangerous | $12,140 | -21.3% | 31 | +1 | $391 | $102,633 | 3 | Distribution Company | false | false |
| 16 | - | Emma's Bliss | $10,043 | - | 5 | - | $2,008 | $10,043 | 1 | Primer Plano Film Group | true | false |
| 17 | 11 | Rudo y Cursi | $9,092 | -56.2% | 26 | -10 | $349 | $300,819 | 4 | United International Pictures | false | false |
| 18 | 17 | The Duchess | $8,274 | +55.4% | 14 | +5 | $591 | $248,283 | 8 | United International Pictures | false | false |
| 19 | 14 | Blame it on Fidel | $7,298 | -22.6% | 7 | - | $1,042 | $22,066 | 2 | Zeta Films | false | false |
| 20 | 15 | W. | $6,938 | -23.7% | 10 | -3 | $693 | $61,417 | 3 | Impacto Cine | false | false |
| 21 | 33 | The Boy in the Striped Pajamas | $5,356 | +975.5% | 9 | +6 | $595 | $83,564 | 9 | Walt Disney Pictures | false | false |
| 22 | 16 | Four Christmases | $3,937 | -30.6% | 13 | -4 | $302 | $414,052 | 7 | Distribution Company | false | false |
| 23 | 20 | Body of Lies | $3,711 | -11.8% | 11 | -5 | $337 | $918,046 | 10 | Warner Bros. | false | false |
| 24 | 18 | Righteous Kill | $3,373 | -36.3% | 8 | -4 | $421 | $573,076 | 11 | CDI Films | false | false |
| 25 | 25 | Quarantine | $2,423 | +78% | 8 | +4 | $302 | $368,600 | 9 | Sony Pictures Releasing | false | false |
| 26 | 23 | Late Bloomers | $2,159 | -4.3% | 5 | +1 | $431 | $75,249 | 10 | Primer Plano Film Group | false | false |
| 27 | 19 | RocknRolla | $2,122 | -54.8% | 13 | +5 | $163 | $88,648 | 8 | Warner Bros. | false | false |
| 28 | 22 | Deception | $2,001 | -20.8% | 4 | +1 | $500 | $66,758 | 8 | Alfa Films | false | false |
| 29 | 27 | Aniceto | $1,433 | +43% | 4 | +1 | $358 | $136,179 | 34 | Primer Plano Film Group | false | false |
| 30 | 26 | Che: Part One | $1,329 | +3.8% | 3 | +1 | $443 | $663,891 | 12 | Alfa Films | false | false |
| 31 | 21 | High School Musical 3: Senior Year | $1,159 | -66.9% | 11 | +1 | $105 | $1,312,670 | 10 | Walt Disney Pictures | false | false |
| 32 | - | Tear This Heart Out | $860 | - | 4 | - | $215 | $56,234 | 10 | 20th Century Fox International | false | false |
| 33 | 24 | Planet Terror | $697 | -67.9% | 6 | +2 | $116 | $92,797 | 8 | Pachamama Cine | false | false |
| 34 | 32 | The Pope's Toilet | $695 | +7.4% | 4 | +2 | $173 | $27,667 | 5 | Primer Plano Film Group | false | false |
| 35 | 54 | Ben X | $614 | +1,397.6% | 2 | +1 | $307 | $27,023 | 5 | Distribution Company | false | false |
| 36 | 36 | Manual of Love 2008 Re-release | $329 | -3.2% | 2 | - | $164 | $135,433 | 19 | Notro Films | false | false |
| 37 | 34 | Death Sentence | $266 | -44.7% | 3 | - | $88 | $187,425 | 9 | Distribution Company | false | false |
| 38 | 29 | The Tracker 2008 Re-release | $243 | -68.8% | 1 | -1 | $243 | $47,532 | 6 | IFA | false | false |
| 39 | 39 | Fados | $222 | -12.3% | 1 | - | $222 | $35,233 | 10 | Distribution Company | false | false |
| 40 | 30 | Asterix at the Olympic Games | $214 | -71.5% | 2 | -9 | $107 | $47,523 | 4 | Distribution Company | false | false |
| 41 | 51 | Bella | $206 | +136.8% | 1 | - | $206 | $31,068 | 6 | CDI Films | false | false |
| 42 | 41 | Fly Me to the Moon 3D | $190 | -15.9% | 2 | - | $95 | $77,266 | 7 | Distribution Company | false | false |
| 43 | 44 | Burn After Reading | $149 | -14.4% | 1 | - | $149 | $841,657 | 15 | United International Pictures | false | false |
| 44 | 45 | Max Payne | $132 | -15.4% | 1 | - | $132 | $165,343 | 11 | 20th Century Fox International | false | false |
| 45 | - | The Camera Obscura 2008 Re-release | $132 | - | 1 | - | $132 | $64,323 | 16 | Distribution Company | false | false |
| 46 | 42 | La próxima estación | $118 | -47.1% | 1 | - | $118 | $43,769 | 22 | Primer Plano Film Group | false | false |
| 47 | 40 | Beverly Hills Chihuahua | $104 | -57.4% | 4 | +2 | $26 | $1,517,468 | 17 | Walt Disney Pictures | false | false |
| 48 | 50 | Shara | $86 | -7.5% | 1 | - | $86 | $43,709 | 14 | Zeta Films | false | false |
| 49 | 52 | Mamma Mia! | $74 | -1.3% | 1 | - | $74 | $1,419,034 | 24 | United International Pictures | false | false |
| 50 | 43 | Café de los maestros | $60 | -67.7% | 1 | - | $60 | $96,243 | 32 | Alfa Films | false | false |
| 51 | 48 | Two Friends and a Burglar | $42 | -67.9% | 1 | - | $42 | $9,844 | 10 | Primer Plano Film Group | false | false |
| 52 | 38 | Saw V | $26 | -90.8% | 2 | - | $13 | $1,049,100 | 14 | Walt Disney Pictures | false | false |
