| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Yes Man | $497,903 | - | 60 | - | $8,298 | $497,903 | 1 | Warner Bros. | true | false |
| 2 | - | Hotel for Dogs | $240,334 | - | 42 | - | $5,722 | $240,334 | 1 | N/A | true | false |
| 3 | 2 | Seven Pounds | $190,820 | -29.3% | 39 | +4 | $4,892 | $621,438 | 2 | N/A | false | false |
| 4 | 1 | Marley & Me | $190,472 | -45.3% | 38 | -2 | $5,012 | $701,641 | 2 | N/A | false | false |
| 5 | 4 | Twilight | $82,477 | -49.6% | 33 | -18 | $2,499 | $2,573,135 | 6 | N/A | false | false |
| 6 | - | Quarantine | $77,130 | - | 21 | - | $3,672 | $77,130 | 1 | N/A | true | false |
| 7 | - | Changeling | $63,500 | - | 24 | - | $2,645 | $78,600 | 1 | N/A | true | false |
| 8 | 5 | Bolt | $63,277 | -56.3% | 46 | -11 | $1,375 | $2,114,824 | 6 | N/A | false | false |
| 9 | 3 | Madagascar: Escape 2 Africa | $56,957 | -68.3% | 50 | -12 | $1,139 | $5,365,265 | 7 | N/A | false | false |
| 10 | 6 | Bangkok Dangerous | $52,811 | -55.1% | 23 | -1 | $2,296 | $259,027 | 2 | N/A | false | false |
| 11 | 11 | The Marsh | $25,471 | -47.8% | 9 | -1 | $2,830 | $220,381 | 3 | N/A | false | false |
| 12 | 14 | A mi me gusta | $20,331 | -40% | 13 | -3 | $1,563 | $546,045 | 7 | N/A | false | false |
| 13 | 10 | Burn After Reading | $15,052 | -72.2% | 15 | -20 | $1,003 | $356,286 | 3 | N/A | false | false |
| 14 | 8 | The Abandoned | $14,980 | -73.3% | 10 | -3 | $1,498 | $254,830 | 3 | N/A | false | false |
| 15 | 12 | RocknRolla | $11,439 | -76.1% | 15 | -10 | $762 | $90,773 | 2 | N/A | false | false |
| 16 | 9 | Four Christmases | $10,981 | -79.8% | 15 | -15 | $732 | $1,223,751 | 5 | N/A | false | false |
| 17 | 15 | Australia | $10,870 | -48.4% | 4 | -6 | $2,717 | $777,084 | 5 | N/A | false | false |
| 18 | 7 | The Tale of Despereaux | $9,640 | -84.1% | 7 | -27 | $1,377 | $735,638 | 4 | N/A | false | false |
| 19 | 17 | The Boy in the Striped Pajamas | $5,756 | -60% | 7 | -2 | $822 | $281,587 | 10 | N/A | false | false |
| 20 | 13 | The Day the Earth Stood Still | $4,442 | -87.9% | 7 | -16 | $634 | $2,346,906 | 7 | N/A | false | false |
| 21 | 18 | Body of Lies | $2,466 | -55.4% | 1 | -1 | $2,466 | $584,341 | 7 | N/A | false | false |
| 22 | 16 | Max Payne | $1,116 | -94% | 3 | -16 | $372 | $614,005 | 4 | N/A | false | false |
