| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Italians | $6,179,760 | - | 611 | - | $10,114 | $6,215,518 | 1 | Filmauro | true | false |
| 2 | 2 | Journey to the Center of the Earth | $2,038,582 | -25.4% | 273 | -3 | $7,467 | $5,585,728 | 2 | 01 Distribution | false | false |
| 3 | 1 | Seven Pounds | $1,578,524 | -53.8% | 378 | -167 | $4,175 | $12,762,070 | 3 | Sony Pictures Releasing | false | false |
| 4 | 3 | Australia | $1,511,824 | -39.7% | 445 | -40 | $3,397 | $4,802,717 | 2 | 20th Century Fox International | false | false |
| 5 | 4 | Yes Man | $1,287,890 | -45.5% | 261 | -86 | $4,934 | $8,503,655 | 3 | Warner Bros. | false | false |
| 6 | 5 | Beverly Hills Chihuahua | $1,172,730 | -31.1% | 46 | -202 | $25,494 | $3,203,485 | 2 | Walt Disney Pictures | false | false |
| 7 | - | Milk | $791,504 | - | 149 | - | $5,312 | $791,504 | 1 | BIM Distribuzione | true | false |
| 8 | - | Defiance | $589,635 | - | 188 | - | $3,136 | $589,635 | 1 | Medusa Distribuzione | true | false |
| 9 | 6 | Easy Virtue | $373,032 | -51.7% | 110 | -32 | $3,391 | $2,411,219 | 3 | Eagle Pictures | false | false |
| 10 | - | Four Christmases | $311,232 | - | 123 | - | $2,530 | $311,232 | 1 | Warner Bros. | true | false |
| 11 | - | Whisper | $262,706 | - | 73 | - | $3,598 | $262,706 | 1 | Eagle Pictures | true | false |
| 12 | 10 | Slumdog Millionaire | $211,396 | -23% | 47 | -31 | $4,497 | $3,495,241 | 8 | Lucky Red | false | false |
| 13 | 8 | Madagascar: Escape 2 Africa | $168,918 | -69.1% | 99 | -131 | $1,706 | $32,370,126 | 6 | Universal Pictures International (UPI) | false | false |
| 14 | 7 | Imago mortis | $164,892 | -72.8% | 96 | -67 | $1,717 | $969,464 | 2 | Medusa Distribuzione | false | false |
| 15 | 11 | Waltz with Bashir | $130,125 | -33.7% | 44 | +8 | $2,957 | $605,640 | 3 | Lucky Red | false | false |
| 16 | 12 | The Boy in the Striped Pajamas | $70,766 | -54.5% | 56 | -22 | $1,263 | $2,951,118 | 6 | Walt Disney Pictures | false | false |
| 17 | 14 | Appaloosa | $68,763 | -42.4% | 29 | -8 | $2,371 | $237,799 | 2 | 01 Distribution | false | false |
| 18 | 15 | Lemon Tree | $61,442 | -47.1% | 25 | -14 | $2,457 | $1,130,095 | 7 | Teodora Film | false | false |
| 19 | 16 | The Visitor | $51,274 | -55.3% | 18 | -24 | $2,848 | $1,680,605 | 8 | Bolero Film | false | false |
| 20 | 21 | Empties | $44,574 | -13.2% | 15 | -2 | $2,971 | $118,489 | 2 | Fandango | false | false |
| 21 | 20 | Tony Manero | $32,520 | -42.3% | 14 | -2 | $2,322 | $125,054 | 2 | Ripley's Film | false | false |
| 22 | 13 | Let the Right One In | $19,016 | -84.9% | 10 | -71 | $1,901 | $676,170 | 3 | Bolero Film | false | false |
| 23 | 23 | Stella | $18,809 | -50.9% | 10 | -9 | $1,880 | $481,858 | 8 | Sacher Distribuzione | false | false |
| 24 | 25 | We Can Do That | $13,509 | -28.8% | 9 | -3 | $1,501 | $2,334,909 | 13 | Warner Bros. | false | false |
| 25 | 24 | Happy-Go-Lucky | $12,187 | -62.7% | 6 | -9 | $2,031 | $1,267,204 | 8 | Mikado Film | false | false |
| 26 | 22 | The Duchess | $11,810 | -74.1% | 11 | -22 | $1,073 | $2,876,742 | 5 | BIM Distribuzione | false | false |
| 27 | 17 | Nights in Rodanthe | $9,573 | -89.5% | 10 | -52 | $957 | $8,802,859 | 6 | Warner Bros. | false | false |
| 28 | 28 | Bolt | $8,389 | -13.8% | 15 | -4 | $559 | $7,369,599 | 9 | Walt Disney Pictures | false | false |
| 29 | 33 | Welcome to the Sticks | $4,420 | -35.7% | 3 | - | $1,473 | $4,189,903 | 13 | Medusa Distribuzione | false | false |
| 30 | 27 | As God Commands | $4,348 | -73.7% | 4 | -10 | $1,087 | $4,493,001 | 7 | 01 Distribution | false | false |
| 31 | 18 | The Strangers | $3,682 | -95.9% | 5 | -61 | $736 | $2,715,699 | 4 | Universal Pictures International (UPI) | false | false |
| 32 | 32 | The Class | $3,232 | -57% | 1 | -4 | $3,232 | $2,165,805 | 16 | Mikado Film | false | false |
| 33 | 19 | Il cosmo sul comò | $2,777 | -95.1% | 5 | -25 | $555 | $19,285,300 | 6 | Medusa Distribuzione | false | false |
| 34 | 26 | Lissi und der wilde Kaiser | $2,610 | -84.7% | 11 | -23 | $237 | $598,641 | 4 | Moviemax | false | false |
| 35 | 37 | The Early Bird Catches the Worm | $2,285 | -15.2% | 1 | - | $2,285 | $1,548,999 | 48 | Medusa Distribuzione | false | false |
| 36 | - | The Counterfeiters | $2,011 | - | 2 | - | $1,005 | $349,800 | 53 | Lady Film | false | false |
| 37 | - | Vicky Cristina Barcelona | $1,707 | - | 3 | - | $569 | $8,124,300 | 15 | Medusa Distribuzione | false | false |
| 38 | 31 | Márió, a varázsló | $1,433 | -81.5% | 1 | -2 | $1,433 | $76,526 | 9 | L'Altrofilm | false | false |
| 39 | 30 | Passengers | $1,207 | -85.4% | 1 | -2 | $1,207 | $758,564 | 8 | Moviemax | false | false |
| 40 | 44 | City of Ember | $1,193 | -12.4% | 4 | +1 | $298 | $1,618,068 | 6 | Eagle Pictures | false | false |
| 41 | 35 | Twilight | $1,167 | -62.3% | 1 | -2 | $1,167 | $16,143,000 | 10 | Eagle Pictures | false | false |
| 42 | - | Giovanna's Father | $1,101 | - | 1 | - | $1,101 | $4,840,588 | 20 | Medusa Distribuzione | false | false |
| 43 | - | Kung Fu Panda | $800 | - | 1 | - | $800 | $25,440,999 | 22 | Universal Pictures International (UPI) | false | false |
| 44 | 48 | The Wind Blows Round | $757 | -12.7% | 1 | -1 | $757 | $659,151 | 91 | Aranciafilm | false | false |
| 45 | - | Beket | $618 | - | 1 | - | $618 | $618 | 1 | N/A | true | false |
| 46 | 40 | Comme les autres | $612 | -62.9% | 2 | +1 | $306 | $189,409 | 6 | Archibald | false | false |
| 47 | - | Galantuomini | $483 | - | 3 | - | $161 | $734,720 | 10 | 01 Distribution | false | false |
| 48 | 45 | Gomorrah | $469 | -63.5% | 1 | -1 | $469 | $17,659,400 | 37 | 01 Distribution | false | false |
| 49 | - | Noah's Ark | $328 | - | 1 | - | $328 | $1,056,897 | 17 | Eagle Pictures | false | false |
| 50 | - | Andres and me | $293 | - | 1 | - | $293 | $49,196 | 42 | N/A | false | false |
