| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $438,047 | - | 51 | - | $8,589 | $443,031 | 1 | Warner Bros. | true | false |
| 2 | 1 | Revolutionary Road | $340,684 | -24.5% | 53 | +4 | $6,428 | $1,317,349 | 3 | Universal Pictures International (UPI) | false | false |
| 3 | 5 | Valkyrie | $332,625 | +24.3% | 72 | +22 | $4,619 | $713,199 | 2 | 20th Century Fox International | false | false |
| 4 | 6 | Slumdog Millionaire | $300,671 | +41.3% | 27 | +2 | $11,135 | $963,398 | 4 | Pathé | false | false |
| 5 | 2 | Australia | $223,085 | -36.4% | 62 | -21 | $3,598 | $5,143,167 | 6 | 20th Century Fox International | false | false |
| 6 | 4 | Bolt | $212,768 | -21.5% | 54 | +1 | $3,940 | $626,780 | 10 | Walt Disney Pictures | false | false |
| 7 | - | Transporter 3 | $186,024 | - | 14 | - | $13,287 | $298,734 | 5 | JMH Distribution | false | false |
| 8 | 3 | Seven Pounds | $159,451 | -46.2% | 49 | -12 | $3,254 | $1,515,631 | 4 | Sony Pictures Releasing | false | false |
| 9 | 9 | Changeling | $144,221 | -12.4% | 39 | -2 | $3,697 | $1,171,507 | 12 | Universal Pictures International (UPI) | false | false |
| 10 | 7 | Madagascar: Escape 2 Africa | $143,417 | -24.4% | 79 | -18 | $1,815 | $10,780,273 | 9 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | Twilight | $85,584 | -37.5% | 18 | -6 | $4,754 | $975,847 | 11 | Ascot Elite Entertainment Group | false | false |
| 12 | 11 | Yes Man | $81,119 | -25% | 13 | -3 | $6,239 | $289,517 | 4 | Warner Bros. | false | false |
| 13 | 8 | Saw V | $68,692 | -59.5% | 25 | -2 | $2,747 | $911,497 | 13 | Ascot Elite Entertainment Group | false | false |
| 14 | - | Wild Chicks and Life | $62,549 | - | 10 | - | $6,254 | $62,549 | 1 | Pathé | true | false |
| 15 | - | The Class | $58,386 | - | 8 | - | $7,298 | $571,358 | 19 | Filmcoopi | false | false |
| 16 | 12 | Vicky Cristina Barcelona | $42,260 | -40.1% | 18 | +1 | $2,347 | $2,367,087 | 17 | Frenetic Films | false | false |
| 17 | 13 | Buddenbrooks | $36,375 | -29.6% | 10 | -2 | $3,637 | $709,914 | 6 | Warner Bros. | false | false |
| 18 | 15 | Bedtime Stories | $36,375 | -17.2% | 10 | -25 | $3,637 | $1,278,388 | 6 | Walt Disney Pictures | false | false |
| 19 | 14 | De l'autre côté du lit | $29,438 | -33.6% | 8 | -2 | $3,679 | $260,181 | 4 | Frenetic Films | false | false |
| 20 | 16 | Welcome to the Sticks | $29,308 | -23.4% | 6 | -1 | $4,884 | $9,841,005 | 49 | Pathé | false | false |
| 21 | 17 | Burn After Reading | $20,093 | -35.9% | 15 | -1 | $1,339 | $2,986,509 | 20 | Ascot Elite Entertainment Group | false | false |
| 22 | 21 | Quantum of Solace | $5,739 | -43.5% | 2 | -4 | $2,869 | $10,702,249 | 13 | Walt Disney Pictures | false | false |
| 23 | 22 | Inkheart | $3,925 | -42.8% | 8 | -4 | $490 | $314,807 | 8 | Warner Bros. | false | false |
| 24 | 23 | Milk | $3,227 | -30.9% | 2 | - | $1,613 | $9,746 | 2 | Ascot Elite Entertainment Group | false | false |
| 25 | 24 | Fly Me to the Moon 3D | $3,171 | - | 1 | - | $3,171 | $76,715 | 14 | N/A | false | false |
