| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Seven Pounds | $3,418,532 | -34.9% | 545 | -8 | $6,272 | $10,360,195 | 2 | Sony Pictures Releasing | false | false |
| 2 | - | Journey to the Center of the Earth | $2,733,167 | - | 276 | - | $9,902 | $2,736,707 | 1 | 01 Distribution | true | false |
| 3 | - | Australia | $2,506,610 | - | 485 | - | $5,168 | $2,506,610 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Yes Man | $2,364,068 | -30.5% | 347 | -2 | $6,812 | $6,699,496 | 2 | Warner Bros. | false | false |
| 5 | - | Beverly Hills Chihuahua | $1,702,381 | - | 248 | - | $6,864 | $1,702,381 | 1 | Walt Disney Pictures | true | false |
| 6 | 5 | Easy Virtue | $773,074 | -5.8% | 142 | +16 | $5,444 | $1,853,089 | 2 | Eagle Pictures | false | false |
| 7 | - | Imago mortis | $606,975 | - | 163 | - | $3,723 | $606,975 | 1 | Medusa Distribuzione | true | false |
| 8 | 3 | Madagascar: Escape 2 Africa | $546,564 | -60.2% | 230 | -191 | $2,376 | $32,779,751 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | 4 | Natale a Rio | $281,290 | -69.3% | 137 | -200 | $2,053 | $36,121,167 | 5 | Filmauro | false | false |
| 10 | 11 | Slumdog Millionaire | $274,438 | +16.5% | 78 | -9 | $3,518 | $3,164,495 | 7 | Lucky Red | false | false |
| 11 | 15 | Waltz with Bashir | $196,389 | +49.4% | 36 | +15 | $5,455 | $406,162 | 2 | Lucky Red | false | false |
| 12 | 10 | The Boy in the Striped Pajamas | $155,684 | -44.7% | 78 | -23 | $1,995 | $2,864,158 | 5 | Walt Disney Pictures | false | false |
| 13 | 9 | Let the Right One In | $125,809 | -60.9% | 81 | -51 | $1,553 | $566,603 | 2 | Bolero Film | false | false |
| 14 | - | Appaloosa | $119,374 | - | 37 | - | $3,226 | $119,374 | 1 | 01 Distribution | true | false |
| 15 | 14 | Lemon Tree | $116,125 | -23.5% | 39 | -8 | $2,977 | $1,050,154 | 6 | Teodora Film | false | false |
| 16 | 13 | The Visitor | $114,631 | -36.6% | 42 | -15 | $2,729 | $1,621,048 | 7 | Bolero Film | false | false |
| 17 | 6 | Nights in Rodanthe | $91,271 | -81.6% | 62 | -191 | $1,472 | $8,276,816 | 5 | Warner Bros. | false | false |
| 18 | 7 | The Strangers | $89,003 | -80.7% | 66 | -96 | $1,348 | $2,703,626 | 3 | Universal Pictures International (UPI) | false | false |
| 19 | 8 | Il cosmo sul comò | $56,671 | -87.1% | 30 | -208 | $1,889 | $19,278,832 | 5 | Medusa Distribuzione | false | false |
| 20 | - | Tony Manero | $56,362 | - | 16 | - | $3,522 | $56,362 | 1 | Ripley's Film | true | false |
| 21 | - | Empties | $51,344 | - | 17 | - | $3,020 | $51,344 | 1 | Fandango | true | false |
| 22 | 12 | The Duchess | $45,565 | -76% | 33 | -109 | $1,380 | $2,681,379 | 4 | BIM Distribuzione | false | false |
| 23 | 20 | Stella | $38,304 | -0.3% | 19 | +4 | $2,016 | $416,483 | 7 | Sacher Distribuzione | false | false |
| 24 | 19 | Happy-Go-Lucky | $32,656 | -24.6% | 15 | -6 | $2,177 | $1,184,772 | 7 | Mikado Film | false | false |
| 25 | 22 | We Can Do That | $18,964 | -29.5% | 12 | -1 | $1,580 | $2,357,850 | 12 | Warner Bros. | false | false |
| 26 | 16 | Lissi und der wilde Kaiser | $17,017 | -84.3% | 34 | -73 | $500 | $605,150 | 3 | Moviemax | false | false |
| 27 | 17 | As God Commands | $16,546 | -78.2% | 14 | -50 | $1,181 | $4,458,158 | 6 | 01 Distribution | false | false |
| 28 | 21 | Bolt | $9,729 | -66.2% | 19 | -8 | $512 | $6,950,034 | 8 | Walt Disney Pictures | false | false |
| 29 | 29 | Mamma Mia! | $9,073 | -36.4% | 5 | - | $1,814 | $12,470,001 | 16 | United International Pictures | false | false |
| 30 | - | Passengers | $8,289 | - | 3 | - | $2,763 | $766,798 | 7 | Moviemax | false | false |
| 31 | 38 | Márió, a varázsló | $7,747 | +193.6% | 3 | +1 | $2,582 | $68,975 | 8 | L'Altrofilm | false | false |
| 32 | 32 | The Class | $7,516 | +63% | 5 | +3 | $1,503 | $2,204,304 | 15 | Mikado Film | false | false |
| 33 | 27 | Welcome to the Sticks | $6,874 | -60.4% | 3 | -6 | $2,291 | $4,067,964 | 12 | Medusa Distribuzione | false | false |
| 34 | 37 | A Christmas Tale | $3,170 | +10.8% | 3 | - | $1,056 | $232,740 | 7 | BIM Distribuzione | false | false |
| 35 | 30 | Twilight | $3,097 | -63.8% | 3 | -4 | $1,032 | $15,135,015 | 9 | Eagle Pictures | false | false |
| 36 | 31 | Just a Father | $2,753 | -53.8% | 4 | -3 | $688 | $2,928,304 | 8 | Warner Bros. | false | false |
| 37 | 33 | The Early Bird Catches the Worm | $2,695 | -40% | 1 | - | $2,695 | $1,545,003 | 47 | Medusa Distribuzione | false | false |
| 38 | - | Tutta la vita davanti | $2,188 | - | 1 | - | $2,188 | $6,058,930 | 43 | Medusa Distribuzione | false | false |
| 39 | 18 | The Spirit | $2,073 | -96.8% | 5 | -62 | $414 | $2,896,985 | 4 | Sony Pictures Releasing | false | false |
| 40 | 26 | Comme les autres | $1,650 | -91.6% | 1 | -16 | $1,650 | $192,590 | 5 | Archibald | false | false |
| 41 | 24 | The Day the Earth Stood Still | $1,643 | -93.3% | 4 | -12 | $410 | $6,037,792 | 6 | 20th Century Fox International | false | false |
| 42 | - | Se chiudi gli occhi | $1,641 | - | 2 | - | $820 | $16,255 | 8 | A.B. Film | false | false |
| 43 | 40 | Body of Lies | $1,556 | -25.9% | 2 | - | $778 | $6,005,344 | 9 | Warner Bros. | false | false |
| 44 | 28 | City of Ember | $1,362 | -92% | 3 | -26 | $454 | $1,591,210 | 5 | Eagle Pictures | false | false |
| 45 | - | Gomorrah | $1,284 | - | 2 | - | $642 | $17,658,931 | 36 | 01 Distribution | false | false |
| 46 | 50 | The Fox and the Child | $1,114 | +142.7% | 1 | -1 | $1,114 | $2,398,556 | 44 | Lucky Red | false | false |
| 47 | 34 | W. | $995 | -75.6% | 1 | -2 | $995 | $28,684 | 5 | N/A | false | false |
| 48 | 39 | The Wind Blows Round | $867 | -67.1% | 2 | - | $433 | $672,322 | 90 | Aranciafilm | false | false |
| 49 | - | The Band's Visit | $706 | - | 1 | - | $706 | $919,800 | 44 | Mikado Film | false | false |
| 50 | 25 | Changeling | $613 | -97% | 1 | -11 | $613 | $6,918,443 | 10 | Universal Pictures International (UPI) | false | false |
