| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Twilight | $176,283 | -50.3% | 41 | - | $4,299 | $671,062 | 2 | N/A | false | false |
| 2 | - | Marley & Me | $132,058 | - | 21 | - | $6,288 | $132,058 | 1 | N/A | true | false |
| 3 | 2 | Bolt | $115,386 | -51.4% | 41 | - | $2,814 | $920,192 | 3 | N/A | false | false |
| 4 | - | Seven Pounds | $78,215 | - | 27 | - | $2,896 | $78,215 | 1 | N/A | true | false |
| 5 | 3 | The Tale of Despereaux | $56,740 | -53.6% | 30 | - | $1,891 | $215,368 | 2 | N/A | false | false |
| 6 | 4 | Australia | $30,569 | -64.2% | 36 | - | $849 | $311,895 | 3 | N/A | false | false |
| 7 | 6 | The Forbidden Kingdom | $28,962 | -54.6% | 26 | - | $1,113 | $114,126 | 2 | N/A | false | false |
| 8 | 9 | Four Christmases | $23,058 | -22.4% | 24 | - | $960 | $247,444 | 4 | N/A | false | false |
| 9 | 5 | The Day the Earth Stood Still | $19,465 | -70.5% | 46 | - | $423 | $899,218 | 5 | N/A | false | false |
| 10 | - | The Duchess | $18,123 | - | 6 | - | $3,020 | $18,123 | 1 | N/A | true | false |
| 11 | 7 | Madagascar: Escape 2 Africa | $10,427 | -80.9% | 50 | - | $208 | $1,786,985 | 6 | N/A | false | false |
| 12 | 8 | The Strangers | $8,145 | -81.3% | 23 | - | $354 | $179,627 | 3 | N/A | false | false |
| 13 | - | Forgetting Sarah Marshall | $7,459 | - | 21 | - | $355 | $159,830 | 8 | N/A | false | false |
| 14 | 11 | Burn After Reading | $6,880 | -25.7% | 15 | - | $458 | $79,763 | 4 | N/A | false | false |
| 15 | 10 | Quantum of Solace | $5,187 | -74% | 8 | - | $648 | $528,524 | 8 | N/A | false | false |
| 16 | - | The Mist | $2,457 | - | 18 | - | $136 | $126,911 | 7 | N/A | false | false |
| 17 | 12 | The Host | $370 | -91.8% | 23 | - | $16 | $62,859 | 3 | N/A | false | false |
