| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Yes Man | $306,461 | -19.4% | 60 | - | $5,107 | $1,438,033 | 3 | Warner Bros. | false | false |
| 2 | - | Seven Pounds | $289,542 | - | 30 | - | $9,651 | $293,967 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | De l'autre côté du lit | $260,615 | -2.6% | 26 | +1 | $10,023 | $581,825 | 2 | Belga Films | false | false |
| 4 | 3 | Madagascar: Escape 2 Africa | $233,600 | +4.5% | 104 | -5 | $2,246 | $6,368,948 | 7 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Twilight | $216,043 | +2.9% | 54 | - | $4,000 | $2,649,110 | 8 | Belga Films | false | false |
| 6 | - | Slumdog Millionaire | $172,024 | - | 16 | - | $10,751 | $175,133 | 1 | Cinéart | true | false |
| 7 | 6 | Australia | $132,149 | -12.7% | 80 | -10 | $1,651 | $1,644,695 | 5 | 20th Century Fox International | false | false |
| 8 | 7 | The Duchess | $118,503 | -11.3% | 29 | -1 | $4,086 | $281,967 | 2 | Cinéart | false | false |
| 9 | - | Beauties at War | $118,160 | - | 18 | - | $6,564 | $124,447 | 1 | Belga Films | true | false |
| 10 | 8 | Burn After Reading | $80,750 | -18.1% | 31 | -2 | $2,604 | $1,454,029 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | Bedtime Stories | $75,067 | -10.9% | 47 | +2 | $1,597 | $922,635 | 4 | Walt Disney Pictures | false | false |
| 12 | 5 | Loft | $73,517 | -61.1% | 30 | -2 | $2,450 | $9,144,042 | 13 | Independent Films | false | false |
| 13 | 11 | Transporter 3 | $63,445 | -21.1% | 28 | - | $2,265 | $1,308,258 | 6 | Belga Films | false | false |
| 14 | - | Frost/Nixon | $60,614 | - | 20 | - | $3,030 | $62,774 | 1 | Universal Pictures International (UPI) | true | false |
| 15 | 9 | The Day the Earth Stood Still | $60,544 | -35.5% | 40 | -30 | $1,513 | $2,068,520 | 6 | 20th Century Fox International | false | false |
| 16 | 14 | The Flight Before Christmas | $50,920 | +33.6% | 30 | -3 | $1,697 | $586,043 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 17 | 12 | Two Lovers | $42,534 | -26.2% | 14 | - | $3,038 | $411,928 | 4 | Cinéart | false | false |
| 18 | 18 | Piet Piraat en het zwaard van Zilvertand | $39,679 | +40.3% | 32 | - | $1,239 | $564,731 | 6 | Kinepolis Film Distribution (KFD) | false | false |
| 19 | - | Afterwards | $35,798 | - | 11 | - | $3,254 | $36,950 | 1 | Victory Productions | true | false |
| 20 | 13 | The Heir Apparent: Largo Winch | $35,015 | -31.3% | 17 | - | $2,059 | $565,553 | 5 | Cinéart | false | false |
| 21 | 16 | Trouble at Timpetill | $32,432 | +5.3% | 14 | -2 | $2,316 | $482,105 | 5 | Alternative Films | false | false |
| 22 | 22 | Winter in Wartime | $27,106 | +47% | 13 | - | $2,085 | $325,554 | 7 | Benelux Film Distributors | false | false |
| 23 | - | Il Divo | $23,716 | - | 9 | - | $2,635 | $23,716 | 1 | ABC Distribution | true | false |
| 24 | - | The Broken | $23,536 | - | 5 | - | $4,707 | $85,310 | 1 | Paradiso Entertainment | true | false |
| 25 | 27 | Blinker en de blixvaten | $17,233 | +23% | 24 | -7 | $718 | $270,087 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 26 | 23 | Quantum of Solace | $15,900 | -10.9% | 4 | -5 | $3,975 | $4,722,545 | 11 | Sony Pictures Releasing | false | false |
| 27 | 15 | Appaloosa | $15,779 | -52.9% | 7 | -2 | $2,254 | $71,951 | 2 | Paradiso Entertainment | false | false |
| 28 | 17 | Saw V | $14,819 | -51.8% | 10 | -22 | $1,481 | $660,391 | 5 | Les Films de l'Elysée | false | false |
| 29 | 21 | Changeling | $14,674 | -22.3% | 15 | -2 | $978 | $1,024,584 | 10 | Universal Pictures International (UPI) | false | false |
| 30 | 31 | High School Musical 3: Senior Year | $13,684 | +22.2% | 8 | -5 | $1,710 | $2,820,274 | 12 | Walt Disney Pictures | false | false |
| 31 | 25 | Wild Child | $10,928 | -26.1% | 9 | -3 | $1,214 | $201,921 | 4 | Universal Pictures International (UPI) | false | false |
| 32 | 19 | Incendiary | $10,362 | -59.3% | 9 | -3 | $1,151 | $40,284 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 33 | 28 | The Visitor | $9,734 | -26.2% | 10 | - | $973 | $143,392 | 5 | N/A | false | false |
| 34 | 29 | Vicky Cristina Barcelona | $7,434 | -35.4% | 7 | - | $1,062 | $1,151,236 | 12 | Cinéart | false | false |
| 35 | 33 | Christmas in Paris | $7,319 | +7.6% | 10 | -3 | $731 | $220,127 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 36 | - | Stella | $7,129 | - | 6 | - | $1,188 | $7,675 | 1 | Benelux Film Distributors | true | false |
| 37 | - | Welcome to the Sticks | $6,086 | - | 4 | - | $1,521 | $10,664,300 | 47 | Alternative Films | false | false |
| 38 | 24 | Louise hires a contract killer | $5,652 | -65.1% | 9 | - | $628 | $129,978 | 4 | Les Films de l'Elysée | false | false |
| 39 | 37 | Anubis en het Pad der 7 Zonden | $4,156 | +39.7% | 3 | - | $1,385 | $1,501,904 | 14 | Kinepolis Film Distribution (KFD) | false | false |
| 40 | 26 | Anything for Her | $4,014 | -72.7% | 13 | - | $308 | $75,063 | 3 | Benelux Film Distributors | false | false |
| 41 | 38 | Modern Life | $3,817 | +53.4% | 3 | - | $1,272 | $50,243 | 11 | Benelux Film Distributors | false | false |
| 42 | 41 | Mamma Mia! | $3,190 | +170.3% | 3 | +1 | $1,063 | $3,879,680 | 19 | Universal Pictures International (UPI) | false | false |
| 43 | 20 | Four Christmases | $2,719 | -88.7% | 5 | -15 | $543 | $397,149 | 4 | Warner Bros. | false | false |
| 44 | 30 | The Silent Army | $2,666 | -76.5% | 5 | -3 | $533 | $135,808 | 5 | N/A | false | false |
| 45 | 36 | Agathe Cléry | $2,296 | -54.9% | 6 | -5 | $382 | $305,117 | 7 | Alternative Films | false | false |
| 46 | 39 | Elegy | $1,791 | +6.5% | 6 | -1 | $298 | $190,601 | 13 | Kinepolis Film Distribution (KFD) | false | false |
| 47 | 32 | Pride and Glory | $1,782 | -77% | 2 | -1 | $891 | $200,538 | 7 | Kinepolis Film Distribution (KFD) | false | false |
| 48 | - | The Hessen Conspiracy | $1,569 | - | 4 | - | $392 | $1,569 | 1 | N/A | true | false |
| 49 | 49 | The Edge of Love | $647 | +228.4% | 2 | +1 | $323 | $16,851 | 8 | Belga Films | false | false |
| 50 | 44 | Hunger | $597 | +8% | 3 | -1 | $199 | $37,760 | 10 | Paradiso Entertainment | false | false |
| 51 | 43 | Home | $372 | -47.2% | 4 | - | $93 | $55,371 | 10 | Benelux Film Distributors | false | false |
| 52 | 42 | Public Enemy | $347 | -64.8% | 4 | -1 | $86 | $317,477 | 9 | Kinepolis Film Distribution (KFD) | false | false |
| 53 | 48 | Moscow, Belgium | $343 | +47.8% | 1 | - | $343 | $1,882,566 | 51 | Kinepolis Film Distribution (KFD) | false | false |
| 54 | 46 | A Pain in the Ass | $265 | -13.1% | 2 | - | $132 | $77,071 | 6 | Benelux Film Distributors | false | false |
| 55 | 45 | Son of Rambow | $256 | -17.2% | 3 | -1 | $85 | $5,369 | 4 | Universal Pictures International (UPI) | false | false |
| 56 | 47 | The Wave | $42 | -84.9% | 1 | -1 | $42 | $52,325 | 13 | Paradiso Entertainment | false | false |
