| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Madagascar: Escape 2 Africa | $3,929,528 | -59.7% | 571 | -12 | $6,881 | $29,881,944 | 3 | Universal Pictures International (UPI) | false | false |
| 2 | 1 | Natale a Rio | $3,815,656 | -65.5% | 548 | -50 | $6,962 | $30,690,486 | 3 | Filmauro | false | false |
| 3 | 3 | Il cosmo sul comò | $1,901,860 | -65.9% | 459 | -26 | $4,143 | $16,597,413 | 3 | Medusa Distribuzione | false | false |
| 4 | 4 | Nights in Rodanthe | $1,343,277 | -41.4% | 316 | +44 | $4,250 | $7,058,559 | 3 | Warner Bros. | false | false |
| 5 | - | The Strangers | $1,316,398 | - | 165 | - | $7,978 | $1,316,398 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | 8 | The Duchess | $555,069 | -32.6% | 202 | +42 | $2,747 | $2,121,230 | 2 | BIM Distribuzione | false | false |
| 7 | 9 | The Boy in the Striped Pajamas | $535,001 | -11.9% | 103 | +20 | $5,194 | $2,035,208 | 3 | Walt Disney Pictures | false | false |
| 8 | 5 | The Spirit | $528,623 | -52.1% | 203 | -24 | $2,604 | $2,596,014 | 2 | Sony Pictures Releasing | false | false |
| 9 | 6 | As God Commands | $368,195 | -62.1% | 167 | -77 | $2,204 | $4,309,494 | 4 | 01 Distribution | false | false |
| 10 | 11 | Slumdog Millionaire | $343,167 | -5.8% | 70 | +15 | $4,902 | $2,387,966 | 5 | Lucky Red | false | false |
| 11 | 7 | The Day the Earth Stood Still | $291,654 | -67% | 115 | -88 | $2,536 | $6,108,201 | 4 | 20th Century Fox International | false | false |
| 12 | - | Lissi und der wilde Kaiser | $271,340 | - | 156 | - | $1,739 | $295,439 | 1 | Moviemax | true | false |
| 13 | 13 | The Visitor | $230,564 | +28.7% | 48 | +19 | $4,803 | $1,148,528 | 5 | Bolero Film | false | false |
| 14 | - | The Life Before Her Eyes | $225,240 | - | 82 | - | $2,746 | $228,020 | 1 | Mediafilm | true | false |
| 15 | 15 | Lemon Tree | $194,291 | +40.5% | 43 | +17 | $4,518 | $637,266 | 4 | Teodora Film | false | false |
| 16 | 10 | City of Ember | $153,078 | -70.9% | 94 | -45 | $1,628 | $1,530,469 | 3 | Eagle Pictures | false | false |
| 17 | 14 | Happy-Go-Lucky | $101,654 | -27.3% | 30 | -4 | $3,388 | $1,057,832 | 5 | Mikado Film | false | false |
| 18 | 12 | Bolt | $84,734 | -63.8% | 72 | -60 | $1,176 | $7,161,170 | 6 | Walt Disney Pictures | false | false |
| 19 | 18 | Stella | $55,490 | +16.9% | 19 | +9 | $2,920 | $298,540 | 5 | Sacher Distribuzione | false | false |
| 20 | 17 | We Can Do That | $43,437 | -26.7% | 14 | +3 | $3,102 | $2,374,646 | 10 | Warner Bros. | false | false |
| 21 | 20 | Comme les autres | $30,803 | -30.8% | 15 | +1 | $2,053 | $133,884 | 3 | Archibald | false | false |
| 22 | 16 | Twilight | $25,348 | -61.2% | 12 | -6 | $2,112 | $14,333,337 | 7 | Eagle Pictures | false | false |
| 23 | 21 | Changeling | $25,258 | -30.9% | 9 | -2 | $2,806 | $6,513,701 | 8 | Universal Pictures International (UPI) | false | false |
| 24 | 19 | Mamma Mia! | $24,264 | -45.6% | 7 | +1 | $3,466 | $12,516,683 | 14 | United International Pictures | false | false |
| 25 | 23 | Welcome to the Sticks | $22,804 | -6.3% | 10 | +2 | $2,280 | $3,821,386 | 10 | Medusa Distribuzione | false | false |
| 26 | 22 | Just a Father | $17,917 | -34.4% | 12 | +1 | $1,493 | $3,060,842 | 6 | Warner Bros. | false | false |
| 27 | 24 | A Christmas Tale | $9,154 | -32% | 7 | -1 | $1,307 | $230,436 | 5 | BIM Distribuzione | false | false |
| 28 | 25 | Body of Lies | $6,677 | -33.5% | 3 | - | $2,225 | $6,338,308 | 7 | Warner Bros. | false | false |
| 29 | 28 | The Early Bird Catches the Worm | $6,146 | -2.5% | 1 | -1 | $6,146 | $1,534,013 | 45 | Medusa Distribuzione | false | false |
| 30 | 26 | The Duchess of Langeais | $4,692 | -45% | 1 | - | $4,692 | $222,578 | 78 | Mikado Film | false | false |
| 31 | 30 | The Class | $4,455 | -15.3% | 2 | -1 | $2,227 | $2,306,825 | 13 | Mikado Film | false | false |
| 32 | 27 | WALL·E | $4,315 | -34.5% | 5 | -2 | $863 | $12,195,771 | 12 | Walt Disney Pictures | false | false |
| 33 | 32 | W. | $3,656 | -7.7% | 1 | - | $3,656 | $19,651 | 3 | N/A | false | false |
| 34 | - | Madagascar | $2,859 | - | 1 | - | $2,859 | $28,044,781 | 175 | United International Pictures | false | false |
| 35 | - | Galantuomini | $2,803 | - | 2 | - | $1,401 | $784,194 | 7 | 01 Distribution | false | false |
| 36 | 33 | Rachel Getting Married | $378 | -89.5% | 2 | -5 | $189 | $265,789 | 7 | Sony Pictures Releasing | false | false |
