| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Yes Man | $3,232,955 | -4.8% | 434 | +15 | $7,449 | $9,715,930 | 2 | Warner Bros. | false | false |
| 2 | 2 | Bedtime Stories | $2,704,818 | +19.7% | 461 | - | $5,867 | $8,251,558 | 2 | Walt Disney Pictures | false | false |
| 3 | 4 | Madagascar: Escape 2 Africa | $2,360,722 | +39.7% | 473 | -6 | $4,990 | $29,272,211 | 5 | Paramount Pictures International | false | false |
| 4 | 3 | Australia | $2,197,591 | +16.6% | 463 | +11 | $4,746 | $6,290,297 | 2 | 20th Century Fox International | false | false |
| 5 | 5 | Twilight | $1,995,428 | +18.8% | 423 | -24 | $4,717 | $11,407,375 | 3 | Contender Entertainment Group | false | false |
| 6 | - | The Spirit | $1,964,486 | - | 422 | - | $4,655 | $1,964,486 | 1 | Lionsgate | true | false |
| 7 | - | The Reader | $975,526 | - | 199 | - | $4,902 | $975,526 | 1 | Entertainment Film Distributors | true | false |
| 8 | 6 | The Day the Earth Stood Still | $631,606 | -16.7% | 314 | -64 | $2,011 | $10,110,249 | 4 | 20th Century Fox International | false | false |
| 9 | - | Che: Part One | $624,852 | - | 96 | - | $6,508 | $624,852 | 1 | Optimum Releasing | true | false |
| 10 | 8 | Inkheart | $511,035 | +13.1% | 348 | -33 | $1,468 | $5,109,025 | 4 | Entertainment Film Distributors | false | false |
| 11 | 10 | The Tale of Despereaux | $440,217 | +25.1% | 316 | -86 | $1,393 | $3,020,743 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 11 | Quantum of Solace | $244,188 | -14.6% | 125 | -59 | $1,953 | $79,953,825 | 10 | Sony Pictures Releasing | false | false |
| 13 | 13 | Changeling | $240,864 | +15.6% | 96 | -63 | $2,509 | $6,998,585 | 6 | Universal Pictures International (UPI) | false | false |
| 14 | 7 | Ghajini | $160,307 | -65.4% | 51 | +2 | $3,143 | $867,786 | 2 | Adlabs Films | false | false |
| 15 | 9 | Four Christmases | $140,454 | -65% | 128 | -172 | $1,097 | $14,861,169 | 6 | Entertainment Film Distributors | false | false |
| 16 | 12 | Rab Ne Bana Di Jodi | $112,875 | -53.7% | 38 | -17 | $2,970 | $2,050,321 | 4 | Yash Raj Films | false | false |
| 17 | - | The Sisterhood of the Traveling Pants 2 | $60,045 | - | 102 | - | $588 | $60,045 | 1 | Warner Bros. | true | false |
| 18 | 14 | Transporter 3 | $49,403 | -55.3% | 76 | -72 | $650 | $3,706,127 | 5 | Icon Film Distribution Australia | false | false |
| 19 | 19 | Waltz with Bashir | $20,897 | +38.3% | 5 | -4 | $4,179 | $832,339 | 7 | Artificial Eye | false | false |
| 20 | 60 | City of Ember | $16,290 | +6,495.1% | 90 | +85 | $181 | $2,088,337 | 13 | Entertainment Film Distributors | false | false |
| 21 | - | A Bunch of Amateurs 2008 Re-release | $15,456 | - | 25 | - | $618 | $369,775 | - | Entertainment Film Distributors | - | false |
| 22 | 21 | Dean Spanley 2008 Re-release | $13,672 | -8.6% | 13 | -9 | $1,051 | $221,910 | 4 | Icon Film Distribution Australia | false | false |
| 23 | 17 | Far North | $13,028 | -15.3% | 11 | -6 | $1,184 | $51,973 | 2 | Soda Pictures | false | false |
| 24 | 18 | Gonzo | $12,980 | -14.4% | 9 | -5 | $1,442 | $129,847 | 3 | Optimum Releasing | false | false |
| 25 | 26 | Burn After Reading | $9,955 | +29.6% | 3 | -1 | $3,318 | $12,646,343 | 12 | Universal Pictures International (UPI) | false | false |
| 26 | 16 | High School Musical 3: Senior Year | $8,434 | -59.2% | 24 | -92 | $351 | $33,061,218 | 11 | Walt Disney Pictures | false | false |
| 27 | 38 | The Baader Meinhof Complex | $8,173 | +201.8% | 9 | +5 | $908 | $571,412 | 8 | Momentum Pictures | false | false |
| 28 | 35 | My Best Friend's Girl | $7,021 | +125% | 4 | -1 | $1,755 | $3,005,733 | 7 | Lionsgate | false | false |
| 29 | 20 | Body of Lies | $5,710 | -62.1% | 6 | -7 | $951 | $4,222,432 | 7 | Warner Bros. | false | false |
| 30 | - | Bring Me the Head of Alfredo Garcia | $5,142 | - | 2 | - | $2,571 | $5,142 | 1 | Park Circus | true | false |
| 31 | 31 | I've Loved You So Long | $5,132 | +22.4% | 4 | -1 | $1,283 | $1,708,945 | 15 | Lionsgate | false | false |
| 32 | 29 | The Secret Life of Bees | $4,890 | -0.1% | 6 | - | $815 | $264,059 | 5 | 20th Century Fox International | false | false |
| 33 | 32 | North Face | $4,678 | +35.2% | 4 | - | $1,169 | $45,252 | 4 | Metrodome Distribution | false | false |
| 34 | 28 | Lakeview Terrace | $4,485 | -12.2% | 6 | -7 | $747 | $788,134 | 5 | Sony Pictures Releasing | false | false |
| 35 | 23 | A.R.O.G | $4,245 | -49.7% | 2 | -1 | $2,122 | $79,670 | 4 | Maxximum Film und Kunst GmbH | false | false |
| 36 | 27 | Mamma Mia! | $4,196 | -42.4% | 3 | -8 | $1,398 | $132,312,428 | 26 | Universal Pictures International (UPI) | false | false |
| 37 | 34 | Easy Virtue | $3,557 | +12.7% | 4 | +1 | $889 | $1,905,969 | 9 | Pathé | false | false |
| 38 | 37 | Gomorrah | $3,216 | +16.9% | 2 | -1 | $1,608 | $1,324,361 | 13 | Optimum Releasing | false | false |
| 39 | 33 | The Duchess | $2,968 | -10.4% | 1 | -1 | $2,968 | $11,860,100 | 18 | Pathé | false | false |
| 40 | 36 | Gardens in Autumn 2008 Re-release | $2,948 | +4.5% | 1 | - | $2,948 | $9,858 | 2 | Artificial Eye | false | false |
| 41 | 25 | Igor | $2,848 | -64.5% | 16 | -82 | $178 | $6,555,830 | 13 | Momentum Pictures | false | false |
| 42 | 49 | The Flight Before Christmas | $2,358 | +134.2% | 6 | - | $393 | $78,860 | 6 | Magma Films | false | false |
| 43 | 50 | Summer | $2,213 | +124.4% | 2 | -1 | $1,106 | $57,703 | 5 | Vertigo Films | false | false |
| 44 | 55 | Lorna's Silence | $2,021 | +259% | 6 | +5 | $336 | $40,608 | 6 | New Wave Films | false | false |
| 45 | 22 | Bicycle Thieves 2008 Re-release | $1,871 | -84.2% | 2 | -10 | $935 | $42,122 | 3 | Park Circus | false | false |
| 46 | 41 | What Just Happened | $1,864 | -27.2% | 1 | -1 | $1,864 | $590,148 | 6 | Pathé | false | false |
| 47 | 45 | Kisses | $1,810 | -4.1% | 2 | -2 | $905 | $214,560 | 7 | Element Films | false | false |
| 48 | 52 | The Man from London | $1,650 | +101.7% | 2 | +1 | $825 | $13,957 | 4 | Artificial Eye | false | false |
| 49 | 30 | La Bohème | $1,567 | -65.6% | 2 | -2 | $783 | $28,732 | 3 | Axiom Films | false | false |
| 50 | 59 | Let it Rain | $1,486 | +255.5% | 3 | - | $495 | $234,031 | 9 | Artificial Eye | false | false |
| 51 | 44 | Hunger | $1,262 | -33.4% | 4 | +2 | $315 | $1,129,424 | 10 | Pathé | false | false |
| 52 | 48 | Of Time and the City | $1,141 | +11.3% | 2 | +1 | $570 | $341,031 | 10 | British Film Institute (BFI) | false | false |
| 53 | 51 | Choke | $1,140 | +36.9% | 1 | - | $1,140 | $230,020 | 7 | 20th Century Fox International | false | false |
| 54 | 24 | Silambattam | $1,099 | -86.3% | 2 | -1 | $549 | $32,346 | 3 | Ayngaran International | false | false |
| 55 | 47 | The Nightmare Before Christmas 2009 3D Release | $990 | -35.1% | 2 | -12 | $495 | $202,551 | 6 | Walt Disney Pictures | false | false |
| 56 | - | Patti Smith: Dream of Life | $752 | - | 2 | - | $376 | $16,984 | 5 | Verve Pictures | false | false |
| 57 | 56 | Alexandra | $670 | +35.1% | 1 | - | $670 | $28,777 | 15 | Artificial Eye | false | false |
| 58 | 58 | Flawless | $606 | +41.3% | 1 | - | $606 | $42,294 | 6 | Metrodome Distribution | false | false |
| 59 | - | A Streetcar Named Desire 2008 Re-release | $440 | - | 1 | - | $440 | $32,563 | 8 | British Film Institute (BFI) | false | false |
| 60 | - | The Zone | $439 | - | 1 | - | $439 | $57,298 | 12 | Soda Pictures | false | false |
| 61 | - | Zack and Miri Make a Porno | $324 | - | 1 | - | $324 | $3,661,391 | 8 | Entertainment Film Distributors | false | false |
| 62 | 62 | Quiet Chaos | $273 | +65.5% | 1 | - | $273 | $108,834 | 11 | New Wave Films | false | false |
| 63 | 42 | Julia | $180 | -92.9% | 1 | -2 | $180 | $74,192 | 5 | Chelsea Films | false | false |
| 64 | 64 | 'Tis Autumn: The Search for Jackie Paris | $13 | -89.3% | 1 | - | $13 | $1,871 | 7 | Verve Pictures | false | false |
