| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 2 | Natale a Rio | $11,045,246 | +137.8% | 598 | +6 | $18,470 | $21,881,272 | 2 | Filmauro | false | false |
| 2 | 1 | Madagascar: Escape 2 Africa | $9,760,066 | +56% | 583 | +18 | $16,741 | $21,182,960 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 3 | Il cosmo sul comò | $5,573,923 | +67.7% | 485 | +6 | $11,492 | $12,238,527 | 2 | Medusa Distribuzione | false | false |
| 4 | 4 | Nights in Rodanthe | $2,293,693 | +109.3% | 272 | +23 | $8,432 | $4,345,437 | 2 | Warner Bros. | false | false |
| 5 | - | The Spirit | $1,102,947 | - | 227 | - | $4,858 | $1,495,466 | 1 | Sony Pictures Releasing | true | false |
| 6 | 6 | As God Commands | $971,861 | +71.2% | 244 | -17 | $3,983 | $3,515,252 | 3 | 01 Distribution | false | false |
| 7 | 5 | The Day the Earth Stood Still | $884,118 | +23% | 203 | -63 | $4,355 | $5,391,240 | 3 | 20th Century Fox International | false | false |
| 8 | - | The Duchess | $823,274 | - | 160 | - | $5,145 | $1,039,718 | 1 | BIM Distribuzione | true | false |
| 9 | 8 | The Boy in the Striped Pajamas | $607,044 | +180.1% | 83 | +6 | $7,313 | $1,054,449 | 2 | Walt Disney Pictures | false | false |
| 10 | 7 | City of Ember | $525,674 | +85.2% | 139 | +14 | $3,781 | $1,062,829 | 2 | Eagle Pictures | false | false |
| 11 | 9 | Slumdog Millionaire | $364,419 | +89.8% | 55 | -26 | $6,625 | $1,765,203 | 4 | Lucky Red | false | false |
| 12 | 11 | Bolt | $234,214 | +122.3% | 132 | -40 | $1,774 | $7,021,317 | 5 | Walt Disney Pictures | false | false |
| 13 | 12 | The Visitor | $179,182 | +85.7% | 29 | -2 | $6,178 | $746,986 | 4 | Bolero Film | false | false |
| 14 | 13 | Happy-Go-Lucky | $139,916 | +61.3% | 34 | -11 | $4,115 | $866,164 | 4 | Mikado Film | false | false |
| 15 | 14 | Lemon Tree | $138,252 | +123.3% | 26 | +9 | $5,317 | $327,067 | 3 | Teodora Film | false | false |
| 16 | 10 | Twilight | $65,403 | -53.3% | 18 | -68 | $3,633 | $15,874,640 | 6 | Eagle Pictures | false | false |
| 17 | 19 | We Can Do That | $59,297 | +103.8% | 11 | -7 | $5,390 | $2,315,350 | 9 | Warner Bros. | false | false |
| 18 | 18 | Stella | $47,486 | +52.1% | 10 | -4 | $4,748 | $211,344 | 4 | Sacher Distribuzione | false | false |
| 19 | 24 | Mamma Mia! | $44,585 | +357.3% | 6 | - | $7,430 | $12,453,365 | 13 | United International Pictures | false | false |
| 20 | 20 | Comme les autres | $44,489 | +112.5% | 14 | +3 | $3,177 | $85,228 | 2 | Archibald | false | false |
| 21 | 17 | Changeling | $36,566 | +0.5% | 11 | -14 | $3,324 | $6,470,197 | 7 | Universal Pictures International (UPI) | false | false |
| 22 | 16 | Just a Father | $27,305 | -43.6% | 11 | -30 | $2,482 | $3,041,031 | 5 | Warner Bros. | false | false |
| 23 | 21 | Welcome to the Sticks | $24,335 | +26.8% | 8 | -5 | $3,041 | $4,160,391 | 9 | Medusa Distribuzione | false | false |
| 24 | 22 | A Christmas Tale | $13,454 | -29.7% | 8 | -11 | $1,681 | $190,087 | 4 | BIM Distribuzione | false | false |
| 25 | 23 | Body of Lies | $10,041 | -35.7% | 3 | -9 | $3,347 | $6,258,990 | 6 | Warner Bros. | false | false |
| 26 | - | The Duchess of Langeais | $8,531 | - | 1 | - | $8,531 | $195,640 | 77 | Mikado Film | false | false |
| 27 | 33 | WALL·E | $6,585 | +89.7% | 7 | -4 | $940 | $11,612,311 | 11 | Walt Disney Pictures | false | false |
| 28 | 25 | The Early Bird Catches the Worm | $6,305 | -24.4% | 2 | - | $3,152 | $1,521,303 | 44 | Medusa Distribuzione | false | false |
| 29 | 34 | Vicky Cristina Barcelona | $6,211 | +101.5% | 2 | - | $3,105 | $8,116,780 | 11 | Medusa Distribuzione | false | false |
| 30 | 29 | The Class | $5,260 | -16.6% | 3 | -6 | $1,753 | $2,275,690 | 12 | Mikado Film | false | false |
| 31 | 15 | Saw V | $5,006 | -89.9% | 3 | -35 | $1,668 | $3,319,993 | 4 | 01 Distribution | false | false |
| 32 | 31 | W. | $3,961 | -10.9% | 1 | - | $3,961 | $11,130 | 2 | N/A | false | false |
| 33 | 32 | Rachel Getting Married | $3,598 | -8.6% | 7 | - | $514 | $262,632 | 6 | Sony Pictures Releasing | false | false |
| 34 | - | Ho ammazzato Berlusconi | $3,581 | - | 1 | - | $3,581 | $77,794 | 28 | Independent Films | false | false |
| 35 | - | Mid-August Lunch | $3,536 | - | 2 | - | $1,768 | $2,801,431 | 17 | Fandango | false | false |
| 36 | 50 | Quantum of Solace | $3,153 | +239.8% | 5 | -1 | $630 | $9,045,390 | 8 | Sony Pictures Releasing | false | false |
