| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar: Escape 2 Africa | $1,534,246 | -19.2% | 510 | +9 | $3,008 | $10,583,692 | 3 | Paramount Pictures International | false | false |
| 2 | - | Marley & Me | $1,109,787 | - | 172 | - | $6,452 | $1,385,397 | 1 | 20th Century Fox International | true | false |
| 3 | - | Seven Pounds | $1,062,631 | - | 203 | - | $5,234 | $1,310,178 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | Twilight | $971,024 | -32.5% | 321 | - | $3,024 | $3,234,814 | 2 | Paris Filmes | false | false |
| 5 | - | Inkheart | $345,900 | - | 174 | - | $1,987 | $422,415 | 1 | PlayArte Pictures | true | false |
| 6 | 3 | Burn After Reading | $74,412 | -54% | 59 | -42 | $1,261 | $1,828,037 | 5 | Universal Pictures International (UPI) | false | false |
| 7 | - | Good | $55,598 | - | 23 | - | $2,417 | $71,140 | 1 | Imagem Filmes | true | false |
| 8 | 7 | Gomorrah | $42,681 | -21.9% | 27 | -5 | $1,580 | $123,735 | 2 | Paris Filmes | false | false |
| 9 | 6 | Vicky Cristina Barcelona | $39,953 | -41.4% | 38 | -39 | $1,051 | $2,185,451 | 7 | Imagem Filmes | false | false |
| 10 | 4 | Body of Lies | $38,014 | -70.4% | 65 | -36 | $584 | $1,531,035 | 5 | Warner Bros. | false | false |
| 11 | 5 | Transporter 3 | $29,471 | -76.8% | 55 | -45 | $535 | $581,753 | 3 | Imagem Filmes | false | false |
| 12 | 8 | The Boy in the Striped Pajamas | $16,617 | -62.8% | 8 | -12 | $2,077 | $178,689 | 3 | Walt Disney Pictures | false | false |
| 13 | - | Café de los maestros | $14,184 | - | 2 | - | $7,092 | $17,455 | 1 | VideoFilmes | true | false |
| 14 | 11 | High School Musical 3: Senior Year | $13,476 | -48.2% | 111 | -53 | $121 | $5,477,800 | 10 | Walt Disney Pictures | false | false |
| 15 | 10 | Quantum of Solace | $12,745 | -55.8% | 50 | -50 | $254 | $7,351,429 | 8 | Sony Pictures Releasing | false | false |
| 16 | 9 | Between the Sheets | $11,823 | -71.8% | 48 | -48 | $246 | $463,955 | 4 | Imagem Filmes | false | false |
| 17 | 14 | Be Kind Rewind | $9,469 | -52.2% | 11 | +1 | $860 | $93,912 | 3 | Europa Filmes | false | false |
| 18 | 16 | Romance | $5,929 | -66.6% | 32 | -24 | $185 | $842,535 | 7 | Walt Disney Pictures | false | false |
| 19 | 15 | Once Upon a Time in Rio | $4,594 | -75.1% | 12 | -26 | $382 | $475,949 | 6 | Walt Disney Pictures | false | false |
| 20 | 21 | Saw V | $2,938 | -53.5% | 28 | -13 | $104 | $2,420,075 | 9 | Walt Disney Pictures | false | false |
| 21 | 17 | Dan in Real Life | $2,934 | -80.3% | 14 | -23 | $209 | $814,496 | 9 | Europa Filmes | false | false |
| 22 | 19 | The Duchess | $2,826 | -75.5% | 10 | -18 | $282 | $428,208 | 6 | Paramount Pictures International | false | false |
| 23 | 18 | The Strangers | $2,398 | -83.4% | 22 | -31 | $109 | $997,139 | 6 | Paris Filmes | false | false |
| 24 | 27 | Fly Me to the Moon 3D | $774 | -62.2% | 7 | -14 | $110 | $1,603,914 | 12 | PlayArte Pictures | false | false |
| 25 | - | Happy Desert | $727 | - | 3 | - | $242 | $18,312 | 5 | Filmes do Estação | false | false |
| 26 | 34 | Leonera | $699 | -8.7% | 3 | - | $233 | $31,796 | 8 | Walt Disney Pictures | false | false |
| 27 | 24 | Deception | $668 | -84.8% | 5 | -12 | $133 | $209,200 | 4 | Paris Filmes | false | false |
| 28 | 22 | Blindness | $665 | -88% | 6 | -20 | $110 | $3,280,545 | 16 | 20th Century Fox International | false | false |
| 29 | 26 | Appaloosa | $561 | -80.4% | 2 | -1 | $280 | $31,909 | 4 | PlayArte Pictures | false | false |
| 30 | 20 | Traitor | $537 | -92.4% | 8 | -11 | $67 | $216,347 | 7 | PlayArte Pictures | false | false |
| 31 | 38 | Nights in Rodanthe | $366 | +152.4% | 2 | - | $183 | $1,319,010 | 13 | Warner Bros. | false | false |
| 32 | 13 | Max Payne | $350 | -98.5% | 3 | -77 | $116 | $1,002,137 | 6 | 20th Century Fox International | false | false |
| 33 | 28 | The House Bunny | $239 | -87.3% | 4 | -1 | $59 | $318,836 | 12 | Sony Pictures Releasing | false | false |
| 34 | 31 | Step Brothers | $147 | -87.9% | 4 | -6 | $36 | $216,699 | 10 | Sony Pictures Releasing | false | false |
| 35 | 39 | RocknRolla | $59 | -42.7% | 1 | - | $59 | $241,338 | 9 | Warner Bros. | false | false |
| 36 | 40 | Once Upon a Time... | $43 | -18.9% | 1 | - | $43 | $2,814,126 | 23 | Sony Pictures Releasing | false | false |
