| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Madagascar: Escape 2 Africa | $946,647 | +42.7% | 11 | -105 | $86,058 | $4,822,868 | 4 | Universal Pictures International (UPI) | false | false |
| 2 | 5 | Loft | $446,743 | +86.5% | 33 | +1 | $13,537 | $8,416,814 | 10 | Independent Films | false | false |
| 3 | 3 | Australia | $392,903 | +48.3% | 102 | - | $3,851 | $902,192 | 2 | 20th Century Fox International | false | false |
| 4 | 2 | The Day the Earth Stood Still | $359,545 | -1.3% | 80 | -5 | $4,494 | $1,582,832 | 3 | 20th Century Fox International | false | false |
| 5 | - | Bedtime Stories | $329,648 | - | 55 | - | $5,993 | $329,648 | 1 | Walt Disney Pictures | true | false |
| 6 | 4 | Twilight | $322,025 | +30.4% | 54 | +3 | $5,963 | $1,780,834 | 5 | Belga Films | false | false |
| 7 | 7 | Transporter 3 | $237,974 | +18.8% | 28 | - | $8,499 | $922,479 | 3 | Belga Films | false | false |
| 8 | 6 | Burn After Reading | $220,895 | +9.8% | 35 | +1 | $6,311 | $1,015,450 | 3 | Universal Pictures International (UPI) | false | false |
| 9 | - | Four Christmases | $197,621 | - | 25 | - | $7,904 | $197,621 | 1 | Warner Bros. | true | false |
| 10 | 12 | The Flight Before Christmas | $151,893 | +191.1% | 33 | - | $4,602 | $282,184 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 11 | 13 | Piet Piraat en het zwaard van Zilvertand | $135,123 | +167.3% | 32 | - | $4,222 | $329,691 | 3 | Kinepolis Film Distribution (KFD) | false | false |
| 12 | 9 | The Heir Apparent: Largo Winch | $123,592 | +18.3% | 18 | - | $6,866 | $314,190 | 2 | Cinéart | false | false |
| 13 | - | Two Lovers | $118,163 | - | 14 | - | $8,440 | $151,928 | 1 | Cinéart | true | false |
| 14 | 8 | Saw V | $103,802 | -9.3% | 33 | -1 | $3,145 | $511,227 | 2 | Les Films de l'Elysée | false | false |
| 15 | 10 | Trouble at Timpetill | $92,944 | +18.3% | 16 | - | $5,809 | $287,703 | 2 | Alternative Films | false | false |
| 16 | - | Wild Child | $76,757 | - | 16 | - | $4,797 | $87,909 | 1 | Universal Pictures International (UPI) | true | false |
| 17 | 14 | Christmas in Paris | $69,932 | +45.4% | 20 | - | $3,496 | $147,700 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 18 | 11 | Quantum of Solace | $69,223 | +17.5% | 25 | -9 | $2,768 | $5,185,448 | 8 | Sony Pictures Releasing | false | false |
| 19 | 16 | Blinker en de blixvaten | $64,033 | +80.1% | 34 | - | $1,883 | $149,284 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 20 | - | Louise hires a contract killer | $43,839 | - | 14 | - | $3,131 | $52,325 | 1 | Les Films de l'Elysée | true | false |
| 21 | 19 | High School Musical 3: Senior Year | $38,173 | +28% | 19 | -7 | $2,009 | $2,442,243 | 9 | Walt Disney Pictures | false | false |
| 22 | 15 | Winter in Wartime | $35,891 | -10.6% | 12 | -3 | $2,990 | $192,522 | 4 | Benelux Film Distributors | false | false |
| 23 | 17 | Agathe Cléry | $31,094 | -10.4% | 13 | - | $2,391 | $236,924 | 4 | Alternative Films | false | false |
| 24 | 20 | Changeling | $27,909 | +2.3% | 14 | -5 | $1,993 | $850,209 | 7 | Universal Pictures International (UPI) | false | false |
| 25 | 18 | The Silent Army | $24,974 | -20.7% | 9 | -2 | $2,774 | $80,754 | 2 | N/A | false | false |
| 26 | 21 | The Visitor | $20,326 | -21.7% | 12 | +1 | $1,693 | $75,471 | 2 | N/A | false | false |
| 27 | 22 | Body of Lies | $18,964 | -19.3% | 15 | -8 | $1,264 | $783,002 | 6 | Warner Bros. | false | false |
| 28 | - | Ghajini | $16,775 | - | 2 | - | $8,387 | $16,775 | 1 | N/A | true | false |
| 29 | 27 | Vicky Cristina Barcelona | $16,027 | +8.9% | 12 | - | $1,335 | $984,817 | 9 | Cinéart | false | false |
| 30 | 29 | Pride and Glory | $15,505 | +53.6% | 3 | -3 | $5,168 | $154,163 | 4 | Kinepolis Film Distribution (KFD) | false | false |
| 31 | 23 | Secret Defense | $12,625 | -44.9% | 6 | -2 | $2,104 | $46,814 | 2 | Les Films de l'Elysée | false | false |
| 32 | 31 | Journey to the Center of the Earth | $12,491 | +31% | 4 | - | $3,122 | $274,557 | 7 | Warner Bros. | false | false |
| 33 | 33 | Anubis en het Pad der 7 Zonden | $11,424 | +92.6% | 4 | -1 | $2,856 | $1,326,144 | 11 | Kinepolis Film Distribution (KFD) | false | false |
| 34 | 24 | A.R.O.G | $10,505 | -41.9% | 3 | -4 | $3,501 | $191,835 | 4 | Maxximum Film und Kunst GmbH | false | false |
| 35 | 28 | Quiet Chaos | $9,814 | -11.6% | 10 | - | $981 | $75,093 | 4 | Cinéart | false | false |
| 36 | 26 | The House Bunny | $7,638 | -49.2% | 3 | - | $2,546 | $29,165 | 2 | Sony Pictures Releasing | false | false |
| 37 | - | Young@Heart | $6,817 | - | 8 | - | $852 | $12,206 | 1 | ABC Distribution | true | false |
| 38 | 30 | The Class | $6,467 | -32.2% | 7 | -5 | $923 | $728,182 | 13 | Cinéart | false | false |
| 39 | 40 | Elegy | $4,532 | +49.1% | 49 | +43 | $92 | $159,241 | 10 | Kinepolis Film Distribution (KFD) | false | false |
| 40 | 35 | Public Enemy | $3,974 | -30% | 6 | -11 | $662 | $279,569 | 6 | Kinepolis Film Distribution (KFD) | false | false |
| 41 | 36 | Welcome to the Sticks | $3,030 | -44.6% | 5 | -4 | $606 | $10,645,910 | 44 | Alternative Films | false | false |
| 42 | 49 | Modern Life | $2,784 | +67% | 3 | +1 | $928 | $32,570 | 8 | Benelux Film Distributors | false | false |
| 43 | - | Son of Rambow | $2,589 | - | 5 | - | $517 | $2,844 | 1 | Universal Pictures International (UPI) | true | false |
| 44 | 42 | Moscow, Belgium | $2,507 | -12.2% | 2 | -1 | $1,253 | $1,879,301 | 48 | Kinepolis Film Distribution (KFD) | false | false |
| 45 | 37 | Space Chimps | $1,306 | -75.3% | 7 | -9 | $186 | $1,198,216 | 10 | Belga Films | false | false |
| 46 | 25 | A Pain in the Ass | $1,107 | -92.7% | 5 | -9 | $221 | $65,418 | 3 | Benelux Film Distributors | false | false |
| 47 | 55 | Home | $869 | +31.7% | 3 | +1 | $289 | $47,292 | 7 | Benelux Film Distributors | false | false |
| 48 | 53 | The Edge of Love | $847 | +8% | 1 | - | $847 | $12,831 | 5 | Belga Films | false | false |
| 49 | 61 | Mamma Mia! | $631 | +814.5% | 5 | - | $126 | $3,478,254 | 16 | Universal Pictures International (UPI) | false | false |
| 50 | 51 | Nowhere Man | $356 | -71.8% | 3 | -2 | $118 | $25,683 | 5 | Kinepolis Film Distribution (KFD) | false | false |
