| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Curious Case of Benjamin Button | $2,275,397 | - | 251 | - | $9,065 | $2,275,397 | 1 | Warner Bros. | true | false |
| 2 | - | The Day the Earth Stood Still | $2,167,702 | - | 257 | - | $8,434 | $2,167,702 | 1 | 20th Century Fox International | true | false |
| 3 | - | Bedtime Stories | $1,784,655 | - | 356 | - | $5,013 | $1,784,655 | 1 | Walt Disney Pictures | true | false |
| 4 | 1 | Madagascar: Escape 2 Africa | $1,516,084 | -38% | 366 | -2 | $4,142 | $8,304,695 | 3 | Paramount Pictures International | false | false |
| 5 | 3 | Australia | $1,276,575 | +12.3% | 363 | -126 | $3,516 | $17,555,114 | 5 | 20th Century Fox International | false | false |
| 6 | 2 | Twilight | $979,464 | -38.3% | 251 | -55 | $3,902 | $8,979,831 | 4 | - | false | false |
| 7 | 4 | Quantum of Solace | $545,005 | -15.7% | 329 | - | $1,656 | $19,588,572 | 6 | Sony Pictures Releasing | false | false |
| 8 | 6 | Four Christmases | $324,987 | -41.1% | 167 | +148 | $1,946 | $4,324,552 | 4 | Roadshow Films | false | false |
| 9 | 7 | Slumdog Millionaire | $321,023 | +49.2% | 33 | - | $9,727 | $746,313 | 2 | Icon Film Distribution | false | false |
| 10 | 5 | High School Musical 3: Senior Year | $285,039 | -54.5% | 312 | -53 | $913 | $6,745,118 | 4 | Walt Disney Pictures | false | false |
| 11 | - | Vicky Cristina Barcelona | $265,920 | - | 59 | - | $4,507 | $462,655 | 1 | Hopscotch Films | true | false |
| 12 | - | Frost/Nixon | $197,176 | - | 59 | - | $3,341 | $267,912 | 1 | Universal Pictures International (UPI) | true | false |
| 13 | - | I've Loved You So Long | $116,442 | - | 25 | - | $4,657 | $327,283 | 1 | Palace Films | true | false |
| 14 | 18 | Wild Ocean | $33,928 | +118.6% | 2 | - | $16,964 | $751,700 | 28 | IMAX | false | false |
| 15 | 14 | Burn After Reading | $23,337 | -24.4% | 41 | -1 | $569 | $6,604,743 | 11 | Universal Pictures International (UPI) | false | false |
| 16 | 9 | Rab Ne Bana Di Jodi | $20,452 | -67.5% | 14 | -1 | $1,460 | $314,223 | 3 | MG Distribution | false | false |
| 17 | 15 | Santa vs. the Snowman 3D | $16,723 | -44.6% | 2 | - | $8,361 | $1,535,570 | 319 | IMAX | false | false |
| 18 | 12 | City of Ember | $12,857 | -76.7% | 82 | -28 | $156 | $280,852 | 3 | Icon Film Distribution | false | false |
| 19 | 17 | Roman de gare | $11,938 | -40.9% | 5 | -4 | $2,387 | $240,321 | 8 | Arkles Entertainment | false | false |
| 20 | - | The Dark Knight | $8,844 | - | 5 | - | $1,768 | $39,784,503 | 24 | Warner Bros. | false | false |
| 21 | - | Bolt | $4,986 | - | 15 | - | $332 | $4,986 | - | Walt Disney Pictures | - | false |
