| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Madagascar: Escape 2 Africa | $6,255,201 | - | 565 | - | $11,071 | $6,255,273 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | - | Natale a Rio | $4,644,058 | - | 592 | - | $7,844 | $4,650,966 | 1 | Filmauro | true | false |
| 3 | - | Il cosmo sul comò | $3,322,943 | - | 479 | - | $6,937 | $3,322,943 | 1 | Medusa Distribuzione | true | false |
| 4 | - | Nights in Rodanthe | $1,095,718 | - | 249 | - | $4,400 | $1,095,718 | 1 | Warner Bros. | true | false |
| 5 | 1 | The Day the Earth Stood Still | $718,957 | -68.8% | 266 | -182 | $2,702 | $3,934,631 | 2 | 20th Century Fox International | false | false |
| 6 | 2 | As God Commands | $567,836 | -46.5% | 261 | +14 | $2,175 | $2,082,434 | 2 | 01 Distribution | false | false |
| 7 | - | City of Ember | $283,826 | - | 125 | - | $2,270 | $283,826 | 1 | Eagle Pictures | true | false |
| 8 | - | The Boy in the Striped Pajamas | $216,714 | - | 77 | - | $2,814 | $216,714 | 1 | Walt Disney Pictures | true | false |
| 9 | 9 | Slumdog Millionaire | $191,959 | -38.3% | 81 | -22 | $2,369 | $1,244,628 | 3 | Lucky Red | false | false |
| 10 | 4 | Twilight | $140,090 | -82.1% | 86 | -199 | $1,628 | $15,579,057 | 5 | Eagle Pictures | false | false |
| 11 | 3 | Bolt | $105,369 | -87.1% | 172 | -244 | $612 | $6,657,059 | 4 | Walt Disney Pictures | false | false |
| 12 | 15 | The Visitor | $96,465 | -24.3% | 31 | -7 | $3,111 | $498,974 | 3 | Bolero Film | false | false |
| 13 | 14 | Happy-Go-Lucky | $86,732 | -45.6% | 45 | -30 | $1,927 | $663,312 | 3 | Mikado Film | false | false |
| 14 | 18 | Lemon Tree | $61,923 | +17.1% | 17 | +7 | $3,642 | $143,703 | 2 | Teodora Film | false | false |
| 15 | 5 | Saw V | $49,544 | -91.7% | 38 | -234 | $1,303 | $3,313,468 | 3 | 01 Distribution | false | false |
| 16 | 6 | Just a Father | $48,401 | -88.7% | 41 | -171 | $1,180 | $2,943,648 | 4 | Warner Bros. | false | false |
| 17 | 8 | Changeling | $36,397 | -88.6% | 25 | -160 | $1,455 | $7,075,646 | 6 | Universal Pictures International (UPI) | false | false |
| 18 | 22 | Stella | $31,229 | -8.2% | 14 | - | $2,230 | $143,739 | 3 | Sacher Distribuzione | false | false |
| 19 | 17 | We Can Do That | $29,091 | -62.5% | 18 | -40 | $1,616 | $2,215,140 | 8 | Warner Bros. | false | false |
| 20 | - | Comme les autres | $20,935 | - | 11 | - | $1,903 | $20,935 | 1 | Archibald | true | false |
| 21 | 20 | Welcome to the Sticks | $19,196 | -52.9% | 13 | -12 | $1,476 | $4,131,712 | 8 | Medusa Distribuzione | false | false |
| 22 | 19 | A Christmas Tale | $19,139 | -57% | 19 | -19 | $1,007 | $187,252 | 3 | BIM Distribuzione | false | false |
| 23 | 7 | Body of Lies | $15,607 | -96.1% | 12 | -179 | $1,300 | $6,242,078 | 5 | Warner Bros. | false | false |
| 24 | 26 | Mamma Mia! | $9,750 | -50.9% | 6 | -5 | $1,625 | $11,163,002 | 12 | United International Pictures | false | false |
| 25 | 36 | The Early Bird Catches the Worm | $8,344 | +27.1% | 2 | - | $4,172 | $1,512,311 | 43 | Medusa Distribuzione | false | false |
| 26 | 13 | Passengers | $6,878 | -96.1% | 8 | -92 | $859 | $779,722 | 3 | Moviemax | false | false |
| 27 | 10 | La fidanzata di papà | $6,393 | -97.8% | 8 | -118 | $799 | $9,471,031 | 6 | Medusa Distribuzione | false | false |
| 28 | 25 | Galantuomini | $6,358 | -71.3% | 6 | -23 | $1,059 | $767,430 | 5 | 01 Distribution | false | false |
| 29 | 30 | The Class | $6,304 | -53% | 9 | -4 | $700 | $2,269,312 | 11 | Mikado Film | false | false |
| 30 | - | Gomorrah | $4,750 | - | 7 | - | $678 | $17,655,103 | 32 | 01 Distribution | false | false |
| 31 | - | W. | $4,446 | - | 1 | - | $4,446 | $4,921 | 1 | N/A | true | false |
| 32 | 24 | Rachel Getting Married | $3,937 | -82.4% | 7 | -9 | $562 | $257,791 | 5 | Sony Pictures Releasing | false | false |
| 33 | 28 | WALL·E | $3,471 | -81.4% | 11 | -13 | $315 | $11,602,311 | 10 | Walt Disney Pictures | false | false |
| 34 | 32 | Vicky Cristina Barcelona | $3,082 | -76.1% | 2 | -11 | $1,541 | $8,109,992 | 10 | Medusa Distribuzione | false | false |
| 35 | 29 | The Orphanage | $3,037 | -78.2% | 3 | -10 | $1,012 | $2,036,551 | 6 | Lucky Red | false | false |
| 36 | 21 | Ti stramo: Ho voglia di un'ultima notte da manuale prima di tre baci sopra il cielo | $2,724 | -92.3% | 2 | -26 | $1,362 | $606,209 | 4 | Mikado Film | false | false |
| 37 | 41 | Burn After Reading | $2,620 | -2.4% | 2 | - | $1,310 | $8,484,374 | 14 | Medusa Distribuzione | false | false |
| 38 | - | Paris | $2,207 | - | 1 | - | $2,207 | $695,130 | 13 | BIM Distribuzione | false | false |
| 39 | 31 | Palermo Shooting | $2,108 | -84% | 3 | -10 | $702 | $163,763 | 4 | BIM Distribuzione | false | false |
| 40 | 33 | High School Musical 3: Senior Year | $1,873 | -76.9% | 3 | -13 | $624 | $12,735,606 | 8 | Walt Disney Pictures | false | false |
| 41 | - | Machan | $1,819 | - | 2 | - | $909 | $222,580 | 15 | Mikado Film | false | false |
| 42 | 35 | The Burning Plain | $1,811 | -72.5% | 2 | -13 | $905 | $1,821,499 | 7 | Medusa Distribuzione | false | false |
| 43 | 50 | Ex Drummer | $1,787 | +51.8% | 2 | +1 | $893 | $83,700 | 12 | L'Altrofilm | false | false |
| 44 | - | The Pursuit of Happyness | $1,589 | - | 1 | - | $1,589 | $21,304,591 | 102 | Medusa Distribuzione | false | false |
| 45 | - | Italian Dream | $1,577 | - | 1 | - | $1,577 | $17,052 | 26 | Lucky Red | false | false |
| 46 | - | The Chronicles of Narnia: Prince Caspian | $1,293 | - | 2 | - | $646 | $11,789,100 | 19 | Walt Disney Pictures | false | false |
| 47 | - | Birdwatchers | $1,235 | - | 1 | - | $1,235 | $482,815 | 16 | 01 Distribution | false | false |
| 48 | 12 | Never Back Down | $1,037 | -99.4% | 2 | -134 | $518 | $2,084,584 | 4 | Medusa Distribuzione | false | false |
| 49 | 23 | Death Race | $1,012 | -96.2% | 2 | -14 | $506 | $418,559 | 4 | Universal Pictures International (UPI) | false | false |
| 50 | 27 | Quantum of Solace | $928 | -95.3% | 6 | -14 | $154 | $9,040,061 | 7 | Sony Pictures Releasing | false | false |
