| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 3 | Madagascar: Escape 2 Africa | $2,444,374 | +59% | 368 | +94 | $6,642 | $4,836,451 | 2 | Paramount Pictures International | false | false |
| 2 | 1 | Twilight | $1,586,449 | -55.4% | 306 | - | $5,184 | $6,577,729 | 3 | - | false | false |
| 3 | 2 | Australia | $1,136,375 | -38.4% | 489 | -95 | $2,323 | $14,429,035 | 4 | 20th Century Fox International | false | false |
| 4 | 5 | Quantum of Solace | $646,673 | -38.3% | 329 | -65 | $1,965 | $17,157,781 | 5 | Sony Pictures Releasing | false | false |
| 5 | 4 | High School Musical 3: Senior Year | $626,242 | -43.9% | 365 | -7 | $1,715 | $5,550,728 | 3 | Walt Disney Pictures | false | false |
| 6 | 6 | Four Christmases | $552,204 | -29.7% | 19 | -181 | $29,063 | $3,382,807 | 3 | Roadshow Films | false | false |
| 7 | - | Slumdog Millionaire | $215,092 | - | 33 | - | $6,517 | $274,713 | 1 | Icon Film Distribution | true | false |
| 8 | - | Vicky Cristina Barcelona | $88,687 | - | 58 | - | $1,529 | $181,366 | - | Hopscotch Films | - | false |
| 9 | 7 | Rab Ne Bana Di Jodi | $62,899 | -52.2% | 15 | - | $4,193 | $261,558 | 2 | MG Distribution | false | false |
| 10 | - | I've Loved You So Long | $61,507 | - | 25 | - | $2,460 | $175,390 | - | Palace Films | - | false |
| 11 | - | Frost/Nixon | $60,547 | - | 49 | - | $1,235 | $60,547 | - | Universal Pictures International (UPI) | - | false |
| 12 | 9 | City of Ember | $55,127 | -34.2% | 110 | -4 | $501 | $206,584 | 2 | Icon Film Distribution | false | false |
| 13 | 8 | Big Stan | $47,480 | -44.4% | 47 | -33 | $1,010 | $1,015,333 | 4 | Hoyts Distribution | false | false |
| 14 | 14 | Burn After Reading | $30,877 | -30.7% | 42 | -8 | $735 | $6,054,058 | 10 | Universal Pictures International (UPI) | false | false |
| 15 | 15 | Santa vs. the Snowman 3D | $30,160 | +10.1% | 2 | - | $15,080 | $1,469,066 | 318 | IMAX | false | false |
| 16 | 13 | Quarantine | $23,886 | -49.4% | 23 | -27 | $1,038 | $711,759 | 4 | Sony Pictures Releasing | false | false |
| 17 | 20 | Roman de gare | $20,206 | +119.1% | 9 | -1 | $2,245 | $218,120 | 7 | Arkles Entertainment | false | false |
| 18 | 16 | Wild Ocean | $15,524 | -14.5% | 2 | - | $7,762 | $694,334 | 27 | IMAX | false | false |
| 19 | - | Beverly Hills Chihuahua | $8,448 | - | 5 | - | $1,689 | $4,608,097 | 12 | Walt Disney Pictures | false | false |
| 20 | 17 | Sex Drive | $7,898 | -46.2% | 13 | -9 | $607 | $1,428,008 | 6 | Hoyts Distribution | false | false |
| 21 | 31 | Fly Me to the Moon 3D | $3,441 | -13.2% | 2 | - | $1,720 | $340,114 | 14 | IMAX | false | false |
| 22 | 32 | The Duchess | $262 | -92.9% | 8 | -7 | $32 | $3,631,592 | 12 | Paramount Pictures International | false | false |
