| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Twilight | $1,693,660 | -31.4% | 387 | -193 | $4,376 | $5,526,907 | 2 | Corazón Films | false | false |
| 2 | - | Body of Lies | $689,608 | - | 326 | - | $2,115 | $689,608 | 1 | Warner Bros. | true | false |
| 3 | 3 | X-mas, Inc. | $599,878 | -18.3% | 422 | -19 | $1,421 | $3,112,130 | 3 | Warner Bros. | false | false |
| 4 | 2 | Quantum of Solace | $464,362 | -49.9% | 395 | -108 | $1,175 | $5,461,033 | 3 | Sony Pictures Releasing | false | false |
| 5 | - | Disaster Movie | $238,267 | - | 200 | - | $1,191 | $238,267 | 1 | Gussi Films | true | false |
| 6 | - | The Women | $118,662 | - | 100 | - | $1,186 | $118,662 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 5 | Mr. Magorium's Wonder Emporium | $104,823 | -16.4% | 149 | -33 | $703 | $1,182,677 | 4 | Zima Entertainment | false | false |
| 8 | 7 | Death Race | $95,461 | +18.8% | 125 | -12 | $763 | $1,291,330 | 5 | Universal Pictures International (UPI) | false | false |
| 9 | - | Wild Child | $76,140 | - | 120 | - | $634 | $76,140 | 1 | Paramount Pictures International | true | false |
| 10 | - | The Boy in the Striped Pajamas | $74,785 | - | 35 | - | $2,136 | $74,785 | 1 | Walt Disney Pictures | true | false |
| 11 | 4 | Death Defying Acts | $72,921 | -53.7% | 89 | -6 | $819 | $317,231 | 2 | Gussi Films | false | false |
| 12 | 6 | High School Musical 3: Senior Year | $71,435 | -39.7% | 169 | -196 | $422 | $4,651,549 | 5 | Walt Disney Pictures | false | false |
| 13 | 9 | Pride and Glory | $59,112 | -13.9% | 114 | +10 | $518 | $1,156,969 | 4 | Gussi Films | false | false |
| 14 | 13 | Saw V | $50,282 | +6.5% | 71 | -12 | $708 | $711,733 | 5 | Walt Disney Pictures | false | false |
| 15 | 8 | The Duchess | $45,799 | -38.5% | 28 | - | $1,635 | $160,540 | 2 | Paramount Pictures International | false | false |
| 16 | 11 | Blindness | $40,032 | -28% | 71 | -31 | $563 | $1,073,263 | 7 | 20th Century Fox International | false | false |
| 17 | 26 | Swing Vote | $36,733 | +167.2% | 79 | +59 | $464 | $226,501 | 4 | Quality Films | false | false |
| 18 | 21 | Space Chimps | $33,349 | +30.5% | 48 | +1 | $694 | $602,231 | 6 | Corazón Films | false | false |
| 19 | - | The Bank Job | $30,144 | - | 40 | - | $753 | $1,726,998 | 14 | Gussi Films | false | false |
| 20 | 15 | Impy's Island | $29,570 | -33.3% | 50 | -16 | $591 | $250,932 | 3 | Gussi Films | false | false |
| 21 | 17 | The Air I Breathe | $28,836 | -23.7% | 65 | -6 | $443 | $769,301 | 7 | Videocine | false | false |
| 22 | - | The Last Legion | $28,607 | - | 53 | - | $539 | $859,746 | 14 | Zima Entertainment | false | false |
| 23 | 10 | The House Bunny | $28,361 | -54.8% | 59 | -46 | $480 | $1,304,656 | 6 | Sony Pictures Releasing | false | false |
| 24 | 18 | Be Kind Rewind | $25,328 | -22.6% | 54 | -5 | $469 | $261,589 | 5 | Videocine | false | false |
| 25 | - | The Ugly Duckling and Me! | $18,818 | - | 21 | - | $896 | $397,367 | 14 | Quality Films | false | false |
| 26 | 30 | Kada kien su karma | $17,989 | +95.2% | 59 | +34 | $304 | $367,500 | 8 | Universal Pictures International (UPI) | false | false |
| 27 | - | Rogue | $16,857 | - | 31 | - | $543 | $301,499 | 11 | Gussi Films | false | false |
| 28 | 16 | My Mom's New Boyfriend | $16,743 | -58% | 35 | -30 | $478 | $1,279,792 | 8 | Zima Entertainment | false | false |
| 29 | 12 | Burn After Reading | $15,361 | -72.2% | 46 | -66 | $333 | $1,899,848 | 6 | Universal Pictures International (UPI) | false | false |
| 30 | 14 | Beverly Hills Chihuahua | $14,536 | -67.8% | 45 | -67 | $323 | $7,654,930 | 9 | Walt Disney Pictures | false | false |
| 31 | 23 | Traitor | $14,392 | -31.2% | 61 | +10 | $235 | $568,555 | 7 | Gussi Films | false | false |
| 32 | 22 | The Strangers | $11,275 | -47.5% | 20 | -17 | $563 | $2,267,529 | 11 | Videocine | false | false |
| 33 | - | Donkey Xote | $8,839 | - | 11 | - | $803 | $2,536,780 | 12 | Videocine | false | false |
| 34 | - | Lake Tahoe | $8,820 | - | 12 | - | $735 | $8,820 | 1 | N/A | true | false |
| 35 | - | Blonde and Blonder | $8,754 | - | 30 | - | $291 | $53,703 | 9 | Quality Films | false | false |
| 36 | 24 | Nights in Rodanthe | $8,693 | -57.1% | 18 | -15 | $482 | $1,813,097 | 9 | Warner Bros. | false | false |
| 37 | 28 | Fly Me to the Moon 3D | $8,307 | -12.5% | 8 | -3 | $1,038 | $2,110,443 | 39 | Gussi Films | false | false |
| 38 | 38 | Funny Games | $7,610 | +146.9% | 21 | +13 | $362 | $210,351 | 10 | Universal Pictures International (UPI) | false | false |
| 39 | 20 | Max Payne | $6,653 | -74.4% | 13 | -55 | $511 | $1,494,634 | 6 | 20th Century Fox International | false | false |
| 40 | 36 | Step Brothers | $6,572 | +44.3% | 14 | +2 | $469 | $633,124 | 10 | Sony Pictures Releasing | false | false |
| 41 | 32 | Spam | $6,094 | -12.5% | 5 | -5 | $1,218 | $502,526 | 6 | Corazón Films | false | false |
| 42 | 35 | The Killing Gene | $5,753 | -1.1% | 15 | -5 | $383 | $138,223 | 5 | Quality Films | false | false |
| 43 | 25 | Under the Salt | $5,632 | -65.8% | 18 | -34 | $312 | $1,680,201 | 7 | Warner Bros. | false | false |
| 44 | 31 | Balls of Fury | $5,150 | -26.9% | 17 | -9 | $302 | $57,866 | 4 | Gussi Films | false | false |
| 45 | 27 | Satanás | $5,060 | -59.8% | 17 | -17 | $297 | $117,206 | 5 | Gussi Films | false | false |
| 46 | - | Unrest | $4,542 | - | 8 | - | $567 | $923,400 | 36 | - | false | false |
| 47 | 34 | Pineapple Express | $4,483 | -27.1% | 24 | -3 | $186 | $121,912 | 8 | Sony Pictures Releasing | false | false |
| 48 | 29 | Dedication 2008 Re-release | $4,290 | -54.2% | 12 | -11 | $357 | $154,386 | 8 | Quality Films | false | false |
| 49 | - | The Last Mistress | $3,869 | - | 4 | - | $967 | $3,869 | 1 | Cinemas Nueva Era | true | false |
| 50 | - | 24 Frames of Terror | $3,828 | - | 16 | - | $239 | $42,097 | 3 | N/A | false | false |
| 51 | - | Apartment 1303 | $3,741 | - | 16 | - | $233 | $88,624 | 7 | Alphaville | false | false |
| 52 | - | La capture | $3,643 | - | 13 | - | $280 | $38,685 | 7 | N/A | false | false |
| 53 | 45 | The Condemned | $3,614 | +1,040.1% | 10 | +8 | $361 | $178,263 | 8 | Corazón Films | false | false |
| 54 | 33 | Mirrors | $3,564 | -47.6% | 7 | -7 | $509 | $3,441,614 | 9 | 20th Century Fox International | false | false |
| 55 | 37 | Teo's Journey | $3,462 | -9.4% | 33 | -6 | $104 | $162,887 | 8 | Videocine | false | false |
| 56 | - | REC | $3,317 | - | 4 | - | $829 | $5,198,503 | 14 | Videocine | false | false |
| 57 | - | Anna M. | $3,214 | - | 9 | - | $357 | $43,421 | 12 | Alphaville | false | false |
| 58 | - | The Host | $3,044 | - | 8 | - | $380 | $148,815 | 13 | Gussi Films | false | false |
| 59 | - | Planet Terror | $2,993 | - | 5 | - | $598 | $61,433 | 25 | Zima Entertainment | false | false |
| 60 | - | The Unknown Woman | $2,816 | - | 11 | - | $256 | $65,577 | 4 | Quality Films | false | false |
| 61 | 39 | Espérame en otro mundo | $2,793 | -0.5% | 16 | -8 | $174 | $33,389 | 6 | Videocine | false | false |
| 62 | - | Forgetting Sarah Marshall | $2,793 | - | 9 | - | $310 | $765,505 | 11 | Universal Pictures International (UPI) | false | false |
| 63 | 19 | Lakeview Terrace | $2,661 | -90.8% | 15 | -35 | $177 | $50,580 | 2 | Sony Pictures Releasing | false | false |
| 64 | - | 4 Months, 3 Weeks and 2 Days | $2,583 | - | 8 | - | $322 | $141,555 | 33 | Zima Entertainment | false | false |
| 65 | - | An American Crime | $2,471 | - | 8 | - | $308 | $557,159 | 17 | Quality Films | false | false |
| 66 | - | Timbiriche: La misma piedra | $1,929 | - | 28 | - | $68 | $18,402 | 1 | Alphaville | true | false |
| 67 | - | Caramel | $1,896 | - | 5 | - | $379 | $79,573 | 10 | Zima Entertainment | false | false |
| 68 | 42 | Molière | $1,871 | +110.7% | 11 | +10 | $170 | $155,421 | 13 | Universal Pictures International (UPI) | false | false |
| 69 | - | Bangkok Dangerous | $1,455 | - | 6 | - | $242 | $1,778,999 | 10 | Gussi Films | false | false |
| 70 | - | Irina Palm | $1,377 | - | 4 | - | $344 | $256,876 | 27 | Zima Entertainment | false | false |
| 71 | - | Mad Money | $1,356 | - | 7 | - | $193 | $829,995 | 16 | Corazón Films | false | false |
| 72 | - | Eros una vez María | $1,245 | - | 2 | - | $622 | $230,735 | 56 | MV Films | false | false |
| 73 | - | Twisted Souls | $1,106 | - | 3 | - | $368 | $80,656 | 47 | - | false | false |
| 74 | - | The Wind that Shakes the Barley 2008 Re-release | $1,102 | - | 1 | - | $1,102 | $1,332 | 1 | Quality Films | true | false |
| 75 | - | A Soap 2008 Re-release | $1,084 | - | 3 | - | $361 | $32,709 | 7 | Alphaville | false | false |
| 76 | - | Íntimamente entre amigas | $910 | - | 4 | - | $227 | $12,450 | 11 | N/A | false | false |
| 77 | - | Tear This Heart Out | $858 | - | 3 | - | $286 | $9,037,101 | 12 | 20th Century Fox International | false | false |
| 78 | - | Death of a President | $831 | - | 1 | - | $831 | $67,735 | 22 | Quality Films | false | false |
| 79 | - | The Diving Bell and the Butterfly | $825 | - | 3 | - | $275 | $351,454 | 24 | Gussi Films | false | false |
| 80 | - | Private Fears in Public Places | $666 | - | 3 | - | $222 | $200,002 | 23 | Alphaville | false | false |
| 81 | - | Death Proof | $554 | - | 3 | - | $184 | $86,887 | 28 | Zima Entertainment | false | false |
| 82 | - | The Other Boleyn Girl | $529 | - | 1 | - | $529 | $1,567,883 | 17 | Gussi Films | false | false |
| 83 | - | Sex and Death 101 | $517 | - | 1 | - | $517 | $199,885 | 15 | Quality Films | false | false |
| 84 | - | The Bubble | $515 | - | 2 | - | $257 | $71,721 | 18 | Alphaville | false | false |
| 85 | - | Trivial | $474 | - | 4 | - | $118 | $52,746 | 43 | - | false | false |
| 86 | - | Familia tortuga | $437 | - | 2 | - | $218 | $8,261 | 5 | Canana Films | false | false |
| 87 | - | Sea Monsters: A Prehistoric Adventure | $425 | - | 1 | - | $425 | $26,160 | 10 | National Geographic Cinema Ventures | false | false |
| 88 | - | College Road Trip | $420 | - | 2 | - | $210 | $2,861,547 | 17 | Walt Disney Pictures | false | false |
| 89 | - | Hunting and Gathering | $414 | - | 2 | - | $207 | $49,727 | 5 | Cinemas Nueva Era | false | false |
| 90 | - | Nesio | $409 | - | 3 | - | $136 | $12,280 | 6 | Film House | false | false |
| 91 | - | Tideland | $371 | - | 2 | - | $185 | $16,013 | 8 | N/A | false | false |
| 92 | - | Reservation Road | $336 | - | 3 | - | $112 | $81,263 | 15 | Zima Entertainment | false | false |
| 93 | - | The Sugar Curtain | $329 | - | 1 | - | $329 | $6,961 | 8 | N/A | false | false |
| 94 | - | Control | $323 | - | 1 | - | $323 | $84,739 | 35 | MV Films | false | false |
| 95 | - | Never Back Down | $303 | - | 2 | - | $151 | $326,998 | 15 | Corazón Films | false | false |
| 96 | - | Bajo Juárez: La ciudad devorando a sus hijas | $265 | - | 1 | - | $265 | $74,807 | 9 | N/A | false | false |
| 97 | - | My Brother 2008 Re-release | $259 | - | 1 | - | $259 | $55,160 | 4 | N/A | false | false |
| 98 | - | U2 3D | $223 | - | 2 | - | $111 | $454,506 | 14 | National Geographic Cinema Ventures | false | false |
| 99 | - | Into Great Silence 2008 Re-release | $191 | - | 2 | - | $95 | $25,898 | 21 | Zima Entertainment | false | false |
| 100 | - | Chapter 27 | $186 | - | 1 | - | $186 | $106,311 | 18 | Film House | false | false |
| 101 | - | Red Like the Sky 2008 Re-release | $154 | - | 1 | - | $154 | $129,403 | 16 | Quality Films | false | false |
| 102 | - | In the Valley of Elah | $133 | - | 1 | - | $133 | $560,344 | 47 | Zima Entertainment | false | false |
| 103 | - | Ira & Abby | $133 | - | 1 | - | $133 | $242,344 | 30 | Corazón Films | false | false |
| 104 | - | Las vidas de Celia | $132 | - | 1 | - | $132 | $33,455 | 31 | Alphaville | false | false |
| 105 | 40 | Frozen River | $126 | -95.5% | 2 | -3 | $63 | $26,068 | 4 | Sony Pictures Releasing | false | false |
| 106 | - | P2 | $124 | - | 1 | - | $124 | $732,996 | 51 | Zima Entertainment | false | false |
| 107 | - | Quatre étoiles 2008 Re-release | $112 | - | 1 | - | $112 | $24,121 | 15 | Cinemas Nueva Era | false | false |
| 108 | - | Factory Girl | $111 | - | 1 | - | $111 | $122,367 | 31 | Film House | false | false |
| 109 | - | Ópera | $102 | - | 1 | - | $102 | $7,595 | 11 | N/A | false | false |
| 110 | - | Used Parts | $78 | - | 1 | - | $78 | $52,449 | 33 | Canana Films | false | false |
| 111 | - | The Wedding Weekend | $55 | - | 1 | - | $55 | $4,354 | 32 | Zima Entertainment | false | false |
| 112 | - | Mezcal | $53 | - | 1 | - | $53 | $32,224 | 77 | Instituto Mexicano de Cinematografía (IMCINE) | false | false |
| 113 | - | Frontier(s) | $43 | - | 1 | - | $43 | $358,000 | 30 | Zima Entertainment | false | false |
| 114 | - | Casi divas | $36 | - | 1 | - | $36 | $3,693,136 | 34 | Sony Pictures Releasing | false | false |
| 115 | - | Into the Wild | $35 | - | 1 | - | $35 | $180,304 | 34 | Paramount Pictures International | false | false |
| 116 | - | The Secret | $5 | - | 1 | - | $5 | $373,145 | 45 | Azteca Films | false | false |
