| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Dark Knight | $3,109,603 | - | 616 | - | $5,048 | $4,990,804 | 1 | Warner Bros. | true | false |
| 2 | 1 | Hellboy II: The Golden Army | $503,626 | -61.7% | 332 | -13 | $1,516 | $3,167,589 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 2 | Get Smart | $261,467 | -42.6% | 216 | -93 | $1,210 | $2,409,272 | 3 | Warner Bros. | false | false |
| 4 | 3 | Wanted | $228,256 | -48.6% | 197 | -103 | $1,158 | $5,331,194 | 4 | Universal Pictures International (UPI) | false | false |
| 5 | 4 | Un'estate al mare | $187,762 | -46.7% | 170 | -107 | $1,104 | $7,343,569 | 5 | Medusa Distribuzione | false | false |
| 6 | 5 | Funny Games | $158,223 | -44.3% | 183 | -17 | $864 | $1,700,224 | 3 | Lucky Red | false | false |
| 7 | 6 | The Deaths of Ian Stone | $122,933 | -46.6% | 92 | -25 | $1,336 | $493,554 | 2 | Medusa Distribuzione | false | false |
| 8 | 8 | Gracie | $75,168 | -39.2% | 95 | -24 | $791 | $289,404 | 2 | Moviemax | false | false |
| 9 | - | P2 | $51,125 | - | 3 | - | $17,041 | $51,125 | 1 | Eagle Pictures | true | false |
| 10 | 11 | Go Go Tales | $41,268 | +3.5% | 23 | +2 | $1,794 | $476,021 | 6 | Mediafilm | false | false |
| 11 | 9 | Fist of the North Star: The Legends of the True Savior: Legend of Raoh-Chapter of Death in Love 2008 Re-release | $38,741 | -42.8% | 55 | - | $704 | $787,585 | 4 | Mikado Film | false | false |
| 12 | 13 | Gomorrah | $31,533 | -17.8% | 28 | -4 | $1,126 | $15,554,224 | 11 | 01 Distribution | false | false |
| 13 | 7 | The Incredible Hulk | $30,297 | -76.1% | 58 | -83 | $522 | $6,222,146 | 6 | Universal Pictures International (UPI) | false | false |
| 14 | 12 | Il Divo | $26,995 | -31% | 24 | -6 | $1,124 | $6,924,596 | 9 | Lucky Red | false | false |
| 15 | - | Black House 2008 Re-release | $17,668 | - | 18 | - | $981 | $17,668 | 1 | Ripley's Film | true | false |
| 16 | 14 | Once | $12,424 | -31.9% | 8 | -9 | $1,553 | $650,536 | 9 | Sacher Distribuzione | false | false |
| 17 | 10 | War | $11,206 | -79.1% | 33 | -16 | $339 | $87,774 | 2 | 01 Distribution | false | false |
| 18 | 15 | The Year My Parents Went on Vacation | $9,357 | -25.2% | 7 | -3 | $1,336 | $354,252 | 8 | Lucky Red | false | false |
| 19 | 39 | The Kite Runner | $8,899 | +153.7% | 7 | +2 | $1,271 | $12,814,011 | 18 | Filmauro | false | false |
| 20 | 31 | Caramel | $8,316 | +82.4% | 8 | +6 | $1,039 | $2,280,103 | 32 | Archibald | false | false |
| 21 | - | Dante 01 | $8,106 | - | 18 | - | $450 | $8,106 | 1 | Warner Bros. | true | false |
| 22 | 25 | The Rest of the Night 2008 Re-release | $6,652 | -23% | 7 | -4 | $950 | $286,324 | 7 | 01 Distribution | false | false |
| 23 | 28 | Ho ammazzato Berlusconi | $6,038 | -5.2% | 1 | - | $6,038 | $80,086 | 6 | Independent Films | false | false |
| 24 | - | Big City | $5,931 | - | 18 | - | $329 | $5,931 | 1 | Warner Bros. | true | false |
| 25 | 18 | Tutta la vita davanti | $5,578 | -53.2% | 9 | - | $619 | $6,093,214 | 18 | Medusa Distribuzione | false | false |
| 26 | 22 | 12 | $5,347 | -42.3% | 9 | -2 | $594 | $110,820 | 5 | 01 Distribution | false | false |
| 27 | 17 | Indiana Jones and the Kingdom of the Crystal Skull | $4,693 | -60.8% | 9 | -6 | $521 | $18,034,265 | 10 | Universal Pictures International (UPI) | false | false |
| 28 | - | The Early Bird Catches the Worm | $4,681 | - | 1 | - | $4,681 | $1,518,376 | 22 | Medusa Distribuzione | false | false |
| 29 | - | Juno | $4,512 | - | 5 | - | $902 | $3,053,369 | 17 | 20th Century Fox International | false | false |
| 30 | 29 | The Darjeeling Limited | $4,273 | -21.8% | 4 | -1 | $1,068 | $1,117,368 | 13 | 20th Century Fox International | false | false |
| 31 | 35 | Things We Lost in the Fire | $3,773 | -3.7% | 3 | -1 | $1,257 | $411,931 | 7 | Teodora Film | false | false |
| 32 | 33 | The Wind Blows Round | $3,678 | -17.4% | 3 | +1 | $1,226 | $687,324 | 65 | Aranciafilm | false | false |
| 33 | 21 | Impy's Island | $3,244 | -65.6% | 12 | -21 | $270 | $164,690 | 5 | Mediafilm | false | false |
| 34 | 16 | The Happening | $3,244 | -73.7% | 12 | -3 | $270 | $3,877,389 | 7 | 20th Century Fox International | false | false |
| 35 | - | Mongol: The Rise of Genghis Khan | $2,880 | - | 4 | - | $720 | $1,326,651 | 12 | BIM Distribuzione | false | false |
| 36 | 44 | Across the Universe | $2,825 | +12.3% | 2 | +1 | $1,412 | $1,233,535 | 36 | Sony Pictures Releasing | false | false |
| 37 | - | Woman's Hearts | $2,765 | - | 5 | - | $553 | $65,231 | 7 | N/A | false | false |
| 38 | - | Shine a Light | $2,439 | - | 2 | - | $1,219 | $479,849 | 16 | BIM Distribuzione | false | false |
| 39 | 46 | Alexandra | $2,363 | +7.3% | 2 | -1 | $1,181 | $71,917 | 9 | N/A | false | false |
| 40 | 34 | In Bruges | $2,285 | -46.5% | 4 | -5 | $571 | $717,037 | 11 | Mikado Film | false | false |
| 41 | 30 | Made of Honor | $2,238 | -56.4% | 6 | -3 | $373 | $2,726,734 | 7 | Sony Pictures Releasing | false | false |
| 42 | 23 | No Country for Old Men | $2,219 | -75.7% | 3 | -5 | $739 | $9,046,215 | 23 | Universal Pictures International (UPI) | false | false |
| 43 | - | Grande, grosso e... Verdone | $2,169 | - | 3 | - | $723 | $20,480,139 | 21 | Filmauro | false | false |
| 44 | 42 | Leatherheads | $2,100 | -25.6% | 2 | -3 | $1,050 | $3,586,156 | 16 | Universal Pictures International (UPI) | false | false |
| 45 | - | 21 | $1,974 | - | 2 | - | $987 | $3,927,213 | 15 | Sony Pictures Releasing | false | false |
| 46 | - | Non pensarci | $1,971 | - | 4 | - | $492 | $2,207,054 | 17 | 01 Distribution | false | false |
| 47 | - | Wild Blood | $1,960 | - | 5 | - | $392 | $932,866 | 10 | 01 Distribution | false | false |
| 48 | - | Iron Man | $1,749 | - | 5 | - | $349 | $10,905,165 | 13 | Universal Pictures International (UPI) | false | false |
| 49 | - | The Secret of the Grain | $1,727 | - | 3 | - | $575 | $2,871,886 | 29 | Lucky Red | false | false |
| 50 | - | I Am Legend | $1,676 | - | 3 | - | $558 | $21,020,300 | 29 | Warner Bros. | false | false |
