| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 3 | Wanted | $163,480 | -35% | 73 | - | $2,239 | $533,188 | 2 | United International Pictures | false | false |
| 2 | 2 | Hancock | $160,786 | -36.6% | 91 | - | $1,766 | $1,453,732 | 3 | Ster-Kinekor Pictures | false | false |
| 3 | 1 | WALL·E | $135,513 | -48.6% | 86 | - | $1,575 | $467,836 | 2 | Ster-Kinekor Pictures | false | false |
| 4 | - | Journey to the Center of the Earth | $115,975 | - | 50 | - | $2,319 | $115,975 | 1 | NuMetro Distribution | true | false |
| 5 | 4 | Kung Fu Panda | $98,067 | -45.5% | 82 | -9 | $1,195 | $1,820,526 | 4 | United International Pictures | false | false |
| 6 | 5 | Get Smart | $56,628 | -44.3% | 60 | -4 | $943 | $561,021 | 3 | NuMetro Distribution | false | false |
| 7 | - | The Bank Job | $46,174 | - | 30 | - | $1,539 | $46,174 | 1 | United International Pictures | true | false |
| 8 | - | Drillbit Taylor | $34,954 | - | 25 | - | $1,398 | $34,954 | 1 | United International Pictures | true | false |
| 9 | 6 | College Road Trip | $25,141 | -42.9% | 30 | -5 | $838 | $565,357 | 5 | Ster-Kinekor Pictures | false | false |
| 10 | - | Kismat Konnection | $16,425 | - | 10 | - | $1,642 | $16,425 | 1 | Ster-Kinekor Pictures | true | false |
| 11 | 7 | Harold & Kumar Escape from Guantanamo Bay | $15,386 | -47.9% | 24 | -1 | $641 | $310,687 | 4 | NuMetro Distribution | false | false |
| 12 | 10 | Sex and the City | $15,014 | -33.3% | 18 | -16 | $834 | $954,582 | 8 | NuMetro Distribution | false | false |
| 13 | - | Skinwalkers | $11,598 | - | 15 | - | $773 | $11,598 | 1 | Ster-Kinekor Pictures | true | false |
| 14 | 9 | What Happens in Vegas | $11,442 | -49.1% | 19 | -15 | $602 | $1,457,892 | 10 | NuMetro Distribution | false | false |
| 15 | 8 | The Incredible Hulk | $6,840 | -71.1% | 20 | -28 | $342 | $920,773 | 6 | United International Pictures | false | false |
| 16 | 15 | Bella | $5,535 | -23% | 7 | - | $790 | $32,097 | 3 | Ster-Kinekor Pictures | false | false |
| 17 | 17 | Married Life | $4,931 | -15.3% | 8 | -2 | $616 | $74,755 | 6 | NuMetro Distribution | false | false |
| 18 | 13 | All the Boys Love Mandy Lane | $4,868 | -42.5% | 15 | - | $324 | $17,989 | 2 | Ster-Kinekor Pictures | false | false |
| 19 | - | Lust, Caution | $4,699 | - | 5 | - | $939 | $4,699 | 1 | Ster-Kinekor Pictures | true | false |
| 20 | 12 | Thoda Pyaar Thoda Magic | $4,176 | -61.3% | 6 | -2 | $696 | $75,519 | 4 | NuMetro Distribution | false | false |
| 21 | 19 | Paris, Je T'aime | $3,805 | -15.6% | 6 | - | $634 | $63,623 | 8 | NuMetro Distribution | false | false |
| 22 | 16 | Forgetting Sarah Marshall | $3,639 | -43.2% | 13 | -5 | $279 | $297,216 | 5 | United International Pictures | false | false |
| 23 | 14 | Definitely, Maybe | $3,392 | -54.9% | 8 | -2 | $424 | $388,333 | 7 | United International Pictures | false | false |
| 24 | 20 | Indiana Jones and the Kingdom of the Crystal Skull | $3,007 | -32.2% | 9 | -2 | $334 | $1,183,326 | 9 | United International Pictures | false | false |
| 25 | 25 | First Sunday | $474 | +59.6% | 1 | - | $474 | $173,534 | 13 | United International Pictures | false | false |
