| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Hellboy II: The Golden Army | $1,316,549 | - | 345 | - | $3,816 | $1,951,958 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 2 | Get Smart | $455,266 | -45.4% | 309 | -7 | $1,473 | $1,897,625 | 2 | Warner Bros. | false | false |
| 3 | 1 | Wanted | $443,904 | -51.2% | 300 | -88 | $1,479 | $4,859,056 | 3 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Un'estate al mare | $352,346 | -55% | 277 | -141 | $1,272 | $6,961,516 | 4 | Medusa Distribuzione | false | false |
| 5 | 4 | Funny Games | $284,313 | -55.6% | 200 | -4 | $1,421 | $1,340,586 | 2 | Lucky Red | false | false |
| 6 | - | The Deaths of Ian Stone | $230,175 | - | 117 | - | $1,967 | $230,175 | 1 | Medusa Distribuzione | true | false |
| 7 | 5 | The Incredible Hulk | $127,006 | -59.2% | 141 | -94 | $900 | $6,138,234 | 5 | Universal Pictures International (UPI) | false | false |
| 8 | - | Gracie | $123,667 | - | 119 | - | $1,039 | $123,667 | 1 | Moviemax | true | false |
| 9 | 6 | Fist of the North Star: The Legends of the True Savior: Legend of Raoh-Chapter of Death in Love 2008 Re-release | $67,689 | -57.9% | 55 | -1 | $1,230 | $698,910 | 3 | Mikado Film | false | false |
| 10 | - | War | $53,510 | - | 49 | - | $1,092 | $53,510 | 1 | 01 Distribution | true | false |
| 11 | 12 | Go Go Tales | $39,867 | -16.3% | 21 | -7 | $1,898 | $393,600 | 5 | Mediafilm | false | false |
| 12 | 11 | Il Divo | $39,098 | -28.9% | 30 | -12 | $1,303 | $6,876,405 | 8 | Lucky Red | false | false |
| 13 | 10 | Gomorrah | $38,381 | -36.9% | 32 | -22 | $1,199 | $15,493,760 | 10 | 01 Distribution | false | false |
| 14 | 17 | Once | $18,257 | -19% | 17 | -5 | $1,073 | $627,250 | 8 | Sacher Distribuzione | false | false |
| 15 | 20 | The Year My Parents Went on Vacation | $12,506 | -14.5% | 10 | -2 | $1,250 | $337,045 | 7 | Lucky Red | false | false |
| 16 | 9 | The Happening | $12,356 | -79.7% | 15 | -41 | $823 | $3,874,146 | 6 | 20th Century Fox International | false | false |
| 17 | 15 | Indiana Jones and the Kingdom of the Crystal Skull | $11,981 | -56.6% | 15 | -10 | $798 | $18,021,627 | 9 | Universal Pictures International (UPI) | false | false |
| 18 | 36 | Tutta la vita davanti | $11,910 | +208.2% | 9 | +6 | $1,323 | $6,082,922 | 17 | Medusa Distribuzione | false | false |
| 19 | 18 | Sex and the City | $11,272 | -47% | 8 | -19 | $1,409 | $10,553,291 | 8 | 01 Distribution | false | false |
| 20 | 8 | Street Kings | $9,625 | -87.2% | 24 | -77 | $401 | $891,049 | 4 | 20th Century Fox International | false | false |
| 21 | 14 | Impy's Island | $9,417 | -65.9% | 33 | -37 | $285 | $156,696 | 4 | Mediafilm | false | false |
| 22 | 22 | 12 | $9,273 | -26.9% | 11 | -1 | $843 | $100,952 | 4 | 01 Distribution | false | false |
| 23 | 33 | No Country for Old Men | $9,115 | +118.7% | 8 | +5 | $1,139 | $9,092,760 | 22 | Universal Pictures International (UPI) | false | false |
| 24 | 7 | Boogeyman 2 | $8,667 | -91.4% | 23 | -129 | $376 | $490,580 | 3 | Eagle Pictures | false | false |
| 25 | 24 | The Rest of the Night 2008 Re-release | $8,639 | -23.9% | 11 | -3 | $785 | $278,126 | 6 | 01 Distribution | false | false |
| 26 | - | College Road Trip | $7,722 | - | 15 | - | $514 | $7,722 | 1 | Walt Disney Pictures | true | false |
| 27 | 19 | Il peso dell'aria | $7,196 | -52.4% | 3 | -2 | $2,398 | $58,560 | 3 | Poker Film | false | false |
| 28 | 47 | Ho ammazzato Berlusconi | $6,372 | +141.6% | 1 | - | $6,372 | $70,768 | 5 | Independent Films | false | false |
| 29 | 26 | The Darjeeling Limited | $5,461 | -24.7% | 5 | -1 | $1,092 | $1,103,823 | 12 | 20th Century Fox International | false | false |
| 30 | 13 | Made of Honor | $5,137 | -86.8% | 9 | -35 | $570 | $2,726,269 | 6 | Sony Pictures Releasing | false | false |
| 31 | - | Caramel | $4,558 | - | 2 | - | $2,279 | $2,266,335 | 31 | Archibald | false | false |
| 32 | - | Before the Devil Knows You're Dead | $4,487 | - | 4 | - | $1,121 | $4,641,676 | 19 | Medusa Distribuzione | false | false |
| 33 | 45 | The Wind Blows Round | $4,455 | +63.1% | 2 | +1 | $2,227 | $687,349 | 64 | Aranciafilm | false | false |
| 34 | 38 | In Bruges | $4,275 | +28.6% | 9 | +5 | $475 | $715,913 | 10 | Mikado Film | false | false |
| 35 | 25 | Things We Lost in the Fire | $3,918 | -48.5% | 4 | -5 | $979 | $404,089 | 6 | Teodora Film | false | false |
| 36 | 16 | Don't Waste Your Time, Johnny! | $3,805 | -84% | 3 | -3 | $1,268 | $654,254 | 34 | Medusa Distribuzione | false | false |
| 37 | 23 | Joshua | $3,709 | -67.5% | 4 | -5 | $927 | $21,545 | 2 | 20th Century Fox International | false | false |
| 38 | - | Into the Wild | $3,617 | - | 3 | - | $1,205 | $8,053,295 | 26 | BIM Distribuzione | false | false |
| 39 | 28 | The Kite Runner | $3,508 | -33.8% | 5 | -2 | $701 | $12,835,014 | 17 | Filmauro | false | false |
| 40 | 21 | Prom Night | $3,370 | -75.8% | 10 | -1 | $337 | $27,070 | 2 | Sony Pictures Releasing | false | false |
| 41 | - | Irina Palm | $3,023 | - | 4 | - | $755 | $2,629,474 | 33 | Teodora Film | false | false |
| 42 | - | Leatherheads | $2,823 | - | 5 | - | $564 | $3,615,000 | 15 | Universal Pictures International (UPI) | false | false |
| 43 | 42 | Amore, bugie & calcetto | $2,555 | -15.7% | 4 | - | $638 | $2,222,029 | 16 | Warner Bros. | false | false |
| 44 | - | Across the Universe | $2,516 | - | 1 | - | $2,516 | $1,239,160 | 35 | Sony Pictures Releasing | false | false |
| 45 | 43 | Elite Squad | $2,397 | -15.2% | 4 | - | $599 | $228,296 | 7 | Mikado Film | false | false |
| 46 | 40 | Alexandra | $2,202 | -31.9% | 3 | -1 | $734 | $68,910 | 8 | N/A | false | false |
| 47 | 34 | Quiet Chaos | $2,159 | -47.2% | 5 | +1 | $431 | $8,492,489 | 24 | 01 Distribution | false | false |
| 48 | - | The Other Boleyn Girl | $2,033 | - | 4 | - | $508 | $2,160,328 | 13 | Universal Pictures International (UPI) | false | false |
| 49 | - | The Diving Bell and the Butterfly | $1,933 | - | 2 | - | $966 | $749,439 | 23 | BIM Distribuzione | false | false |
| 50 | - | Then She Found Me | $1,911 | - | 4 | - | $477 | $935,309 | 7 | Medusa Distribuzione | false | false |
