| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Hancock | $626,195 | - | 91 | - | $6,881 | $626,195 | 1 | Ster-Kinekor Pictures | true | false |
| 2 | 1 | Kung Fu Panda | $286,439 | -46.7% | 106 | - | $2,702 | $1,212,806 | 2 | United International Pictures | false | false |
| 3 | - | Get Smart | $218,917 | - | 65 | - | $3,367 | $218,917 | 1 | NuMetro Distribution | true | false |
| 4 | 4 | College Road Trip | $60,682 | -34.7% | 40 | - | $1,517 | $414,809 | 3 | Ster-Kinekor Pictures | false | false |
| 5 | 3 | The Incredible Hulk | $50,101 | -46.3% | 65 | -6 | $770 | $819,885 | 4 | United International Pictures | false | false |
| 6 | 2 | Harold & Kumar Escape from Guantanamo Bay | $47,492 | -49.2% | 30 | - | $1,583 | $210,389 | 2 | NuMetro Distribution | false | false |
| 7 | 6 | What Happens in Vegas | $37,008 | -36.2% | 50 | -3 | $740 | $1,354,011 | 8 | NuMetro Distribution | false | false |
| 8 | 5 | The Chronicles of Narnia: Prince Caspian | $32,231 | -52.6% | 57 | -20 | $565 | $944,377 | 5 | Ster-Kinekor Pictures | false | false |
| 9 | 7 | Forgetting Sarah Marshall | $26,563 | -50.9% | 43 | -7 | $617 | $250,822 | 3 | United International Pictures | false | false |
| 10 | 8 | Sex and the City | $24,696 | -46.5% | 29 | -15 | $851 | $868,773 | 6 | NuMetro Distribution | false | false |
| 11 | 13 | Thoda Pyaar Thoda Magic | $14,729 | -33.3% | 8 | - | $1,841 | $47,960 | 2 | NuMetro Distribution | false | false |
| 12 | 9 | The Happening | $14,122 | -68% | 29 | -21 | $486 | $362,479 | 4 | NuMetro Distribution | false | false |
| 13 | 11 | Definitely, Maybe | $13,603 | -45.8% | 20 | -8 | $680 | $354,354 | 5 | United International Pictures | false | false |
| 14 | 10 | Indiana Jones and the Kingdom of the Crystal Skull | $11,915 | -54.4% | 20 | -11 | $595 | $1,139,463 | 7 | United International Pictures | false | false |
| 15 | - | Bella | $9,274 | - | 7 | - | $1,324 | $9,274 | 1 | Ster-Kinekor Pictures | true | false |
| 16 | 15 | Married Life | $5,907 | -29.9% | 8 | - | $738 | $56,223 | 4 | NuMetro Distribution | false | false |
| 17 | - | Jaane Tu... Ya Jaane Na | $5,034 | - | 4 | - | $1,258 | $5,034 | 1 | Ster-Kinekor Pictures | true | false |
| 18 | - | Love Story 2050 | $4,983 | - | 7 | - | $711 | $4,983 | 1 | Ster-Kinekor Pictures | true | false |
| 19 | 14 | Iron Man | $4,444 | -59.6% | 13 | -2 | $341 | $1,430,589 | 10 | United International Pictures | false | false |
| 20 | 17 | Goya's Ghosts | $3,792 | -45.4% | 5 | - | $758 | $17,025 | 2 | Ster-Kinekor Pictures | false | false |
| 21 | 12 | Speed Racer | $3,701 | -83.3% | 15 | -47 | $246 | $117,405 | 3 | NuMetro Distribution | false | false |
| 22 | 20 | Rogue | $2,179 | -36.2% | 4 | -2 | $544 | $79,357 | 6 | Ster-Kinekor Pictures | false | false |
| 23 | 22 | First Sunday | $1,542 | -24.6% | 3 | - | $514 | $171,594 | 11 | United International Pictures | false | false |
| 24 | 18 | Made of Honor | $1,057 | -75.8% | 5 | -1 | $211 | $833,804 | 10 | United International Pictures | false | false |
