| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Incredible Hulk | $1,527,891 | - | 477 | - | $3,203 | $2,417,582 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | The Happening | $366,716 | -78.4% | 338 | -25 | $1,084 | $2,766,565 | 2 | 20th Century Fox International | false | false |
| 3 | 2 | Made of Honor | $320,638 | -71% | 292 | -1 | $1,098 | $1,952,227 | 2 | Sony Pictures Releasing | false | false |
| 4 | 4 | Sex and the City | $223,106 | -74.9% | 263 | -156 | $848 | $9,792,943 | 4 | 01 Distribution | false | false |
| 5 | 5 | Gomorrah | $189,399 | -71.4% | 240 | -41 | $789 | $14,622,016 | 6 | 01 Distribution | false | false |
| 6 | 3 | Indiana Jones and the Kingdom of the Crystal Skull | $182,797 | -80.7% | 219 | -110 | $834 | $17,249,690 | 5 | Universal Pictures International (UPI) | false | false |
| 7 | 6 | Il Divo | $177,375 | -73% | 250 | -76 | $709 | $6,167,610 | 4 | Lucky Red | false | false |
| 8 | - | Gardener of Eden | $75,019 | - | 42 | - | $1,786 | $75,019 | 1 | Medusa Distribuzione | true | false |
| 9 | 7 | Things We Lost in the Fire | $46,320 | -72.6% | 89 | -8 | $520 | $287,802 | 2 | Teodora Film | false | false |
| 10 | - | Unknown | $39,371 | - | 24 | - | $1,640 | $39,371 | 1 | Eagle Pictures | true | false |
| 11 | 12 | The Rest of the Night 2008 Re-release | $35,060 | -57.8% | 49 | -12 | $715 | $161,758 | 2 | 01 Distribution | false | false |
| 12 | 13 | Once | $33,626 | -53.1% | 31 | -1 | $1,084 | $434,484 | 4 | Sacher Distribuzione | false | false |
| 13 | - | Go Go Tales | $32,704 | - | 110 | - | $297 | $32,727 | 1 | Mediafilm | true | false |
| 14 | 11 | Superhero Movie | $24,723 | -77.7% | 65 | -15 | $380 | $4,385,381 | 6 | Medusa Distribuzione | false | false |
| 15 | 8 | Feel the Noise | $23,688 | -83.1% | 62 | -56 | $382 | $219,694 | 2 | Mediafilm | false | false |
| 16 | 10 | One Missed Call | $23,556 | -82.5% | 49 | -53 | $480 | $710,345 | 3 | Warner Bros. | false | false |
| 17 | 14 | The Year My Parents Went on Vacation | $18,785 | -66.1% | 17 | -7 | $1,105 | $211,554 | 3 | Lucky Red | false | false |
| 18 | - | Savage Grace | $18,134 | - | 20 | - | $906 | $18,134 | 1 | BIM Distribuzione | true | false |
| 19 | 9 | Then She Found Me | $13,385 | -90.2% | 40 | -98 | $334 | $887,520 | 3 | Medusa Distribuzione | false | false |
| 20 | - | Ho ammazzato Berlusconi | $13,326 | - | 4 | - | $3,331 | $13,326 | 1 | Independent Films | true | false |
| 21 | - | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $12,170 | - | 8 | - | $1,521 | $12,170 | 1 | Walt Disney Pictures | true | false |
| 22 | 15 | Full of It | $10,779 | -79.1% | 25 | -4 | $431 | $76,839 | 2 | Warner Bros. | false | false |
| 23 | 17 | What Happens in Vegas | $9,901 | -74.2% | 13 | -8 | $761 | $5,042,690 | 7 | 20th Century Fox International | false | false |
| 24 | 23 | The Night of the Sunflowers | $8,703 | -40.8% | 9 | - | $967 | $29,557 | 2 | Istituto Luce | false | false |
| 25 | 16 | Wild Blood | $8,450 | -79.7% | 21 | -18 | $402 | $884,783 | 5 | 01 Distribution | false | false |
| 26 | 18 | Elite Squad | $8,021 | -78.1% | 15 | -19 | $534 | $193,400 | 3 | Mikado Film | false | false |
| 27 | 26 | Tuttifrutti | $5,839 | -45.3% | 3 | -2 | $1,946 | $74,636 | 6 | N/A | false | false |
| 28 | 22 | In Bruges | $5,804 | -61.7% | 5 | -4 | $1,160 | $669,367 | 6 | Mikado Film | false | false |
| 29 | - | Don't Waste Your Time, Johnny! | $5,205 | - | 1 | - | $5,205 | $544,099 | 30 | Medusa Distribuzione | false | false |
| 30 | 24 | Woman's Hearts | $4,902 | -65.6% | 5 | +1 | $980 | $25,575 | 2 | N/A | false | false |
| 31 | 33 | Juno | $4,358 | -9.2% | 4 | +3 | $1,089 | $2,983,505 | 12 | 20th Century Fox International | false | false |
| 32 | 25 | The Darjeeling Limited | $3,872 | -69.8% | 4 | -3 | $968 | $1,033,177 | 8 | 20th Century Fox International | false | false |
| 33 | 31 | Non pensarci | $3,702 | -33.7% | 3 | +1 | $1,234 | $2,141,879 | 12 | 01 Distribution | false | false |
| 34 | 19 | Iron Man | $3,497 | -83.5% | 9 | -2 | $388 | $10,763,008 | 8 | Universal Pictures International (UPI) | false | false |
| 35 | 20 | Horton Hears a Who! | $3,385 | -81.6% | 15 | -4 | $225 | $3,468,893 | 10 | 20th Century Fox International | false | false |
| 36 | 29 | Alexandra | $3,238 | -57.6% | 5 | -2 | $647 | $48,515 | 4 | N/A | false | false |
| 37 | 30 | The Wind Blows Round | $2,768 | -51% | 2 | - | $1,384 | $647,051 | 60 | Aranciafilm | false | false |
| 38 | 32 | Tutto torna | $2,626 | -47.2% | 3 | +1 | $875 | $84,447 | 7 | N/A | false | false |
| 39 | 27 | Bratz | $2,270 | -78.4% | 7 | -24 | $324 | $150,460 | 3 | Eagle Pictures | false | false |
| 40 | 28 | Mongol: The Rise of Genghis Khan | $2,184 | -71.7% | 3 | -2 | $728 | $1,283,567 | 7 | BIM Distribuzione | false | false |
| 41 | 36 | Leatherheads | $2,173 | -38.1% | 1 | - | $2,173 | $3,653,382 | 11 | Universal Pictures International (UPI) | false | false |
| 42 | 35 | Tutta la vita davanti | $1,960 | -46.1% | 5 | +2 | $392 | $5,970,217 | 13 | Medusa Distribuzione | false | false |
| 43 | 38 | Be Kind Rewind | $1,559 | -42.2% | 3 | - | $519 | $209,955 | 5 | BIM Distribuzione | false | false |
| 44 | 46 | Maradona by Kusturica | $1,117 | +28.1% | 6 | +4 | $186 | $160,690 | 4 | BIM Distribuzione | false | false |
| 45 | 39 | The Kite Runner | $980 | -47.7% | 3 | - | $326 | $12,600,090 | 13 | Filmauro | false | false |
| 46 | 43 | The Early Bird Catches the Worm | $974 | +1.6% | 1 | - | $974 | $1,481,732 | 17 | Medusa Distribuzione | false | false |
| 47 | 21 | The Hitcher | $897 | -94.9% | 4 | -22 | $224 | $1,092,472 | 4 | Medusa Distribuzione | false | false |
| 48 | 37 | Underdog | $755 | -73.2% | 4 | - | $188 | $74,430 | 6 | Walt Disney Pictures | false | false |
| 49 | 34 | The Other Boleyn Girl | $746 | -82.3% | 3 | -5 | $248 | $2,105,898 | 9 | Universal Pictures International (UPI) | false | false |
| 50 | - | Evening | $713 | - | 2 | - | $356 | $1,136,897 | 9 | Medusa Distribuzione | false | false |
