| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Happening | $1,696,548 | - | 363 | - | $4,673 | $1,882,894 | 1 | 20th Century Fox International | true | false |
| 2 | - | Made of Honor | $1,104,171 | - | 293 | - | $3,768 | $1,228,167 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Indiana Jones and the Kingdom of the Crystal Skull | $947,059 | -46.8% | 329 | -233 | $2,878 | $16,664,522 | 4 | Universal Pictures International (UPI) | false | false |
| 4 | 1 | Sex and the City | $888,670 | -55.4% | 419 | -112 | $2,120 | $9,040,403 | 3 | 01 Distribution | false | false |
| 5 | 3 | Gomorrah | $662,116 | -50.2% | 281 | -68 | $2,356 | $14,073,553 | 5 | 01 Distribution | false | false |
| 6 | 4 | Il Divo | $656,762 | -49.1% | 326 | -32 | $2,014 | $5,686,262 | 3 | Lucky Red | false | false |
| 7 | - | Things We Lost in the Fire | $168,772 | - | 97 | - | $1,739 | $180,381 | 1 | Teodora Film | true | false |
| 8 | - | Feel the Noise | $140,366 | - | 118 | - | $1,189 | $142,751 | 1 | Mediafilm | true | false |
| 9 | 5 | Then She Found Me | $136,427 | -74.4% | 138 | -4 | $988 | $833,987 | 2 | Medusa Distribuzione | false | false |
| 10 | 6 | One Missed Call | $134,510 | -63.4% | 102 | -7 | $1,318 | $647,003 | 2 | Warner Bros. | false | false |
| 11 | 8 | Superhero Movie | $110,704 | -48.7% | 80 | -33 | $1,383 | $4,294,061 | 5 | Medusa Distribuzione | false | false |
| 12 | - | The Rest of the Night 2008 Re-release | $83,100 | - | 61 | - | $1,362 | $96,751 | 1 | 01 Distribution | true | false |
| 13 | 10 | Once | $71,751 | -37.3% | 32 | -3 | $2,242 | $369,711 | 3 | Sacher Distribuzione | false | false |
| 14 | 13 | The Year My Parents Went on Vacation | $55,487 | -35.9% | 24 | -3 | $2,311 | $168,902 | 2 | Lucky Red | false | false |
| 15 | - | Full of It | $51,562 | - | 29 | - | $1,778 | $51,863 | 1 | Warner Bros. | true | false |
| 16 | 14 | Wild Blood | $41,659 | -51.2% | 39 | -33 | $1,068 | $852,714 | 4 | 01 Distribution | false | false |
| 17 | 9 | What Happens in Vegas | $38,418 | -73.4% | 21 | -36 | $1,829 | $4,967,140 | 6 | 20th Century Fox International | false | false |
| 18 | 12 | Elite Squad | $36,662 | -61.8% | 34 | -22 | $1,078 | $170,455 | 2 | Mikado Film | false | false |
| 19 | 15 | Iron Man | $21,141 | -61.2% | 11 | -16 | $1,921 | $10,639,196 | 7 | Universal Pictures International (UPI) | false | false |
| 20 | 19 | Horton Hears a Who! | $18,376 | -23.2% | 19 | -5 | $967 | $3,427,192 | 9 | 20th Century Fox International | false | false |
| 21 | 7 | The Hitcher | $17,558 | -93% | 26 | -140 | $675 | $1,071,213 | 3 | Medusa Distribuzione | false | false |
| 22 | 18 | In Bruges | $15,171 | -38.9% | 9 | -2 | $1,685 | $649,356 | 5 | Mikado Film | false | false |
| 23 | - | The Night of the Sunflowers | $14,709 | - | 9 | - | $1,634 | $14,709 | 1 | Istituto Luce | true | false |
| 24 | - | Woman's Hearts | $14,251 | - | 4 | - | $3,562 | $14,251 | 1 | N/A | true | false |
| 25 | 17 | The Darjeeling Limited | $12,821 | -58.4% | 7 | -9 | $1,831 | $1,010,783 | 7 | 20th Century Fox International | false | false |
| 26 | 30 | Tuttifrutti | $10,675 | +68% | 5 | - | $2,135 | $62,159 | 5 | N/A | false | false |
| 27 | 11 | Bratz | $10,490 | -89.9% | 31 | -118 | $338 | $143,624 | 2 | Eagle Pictures | false | false |
| 28 | 16 | Mongol: The Rise of Genghis Khan | $7,720 | -80% | 5 | -20 | $1,544 | $1,259,325 | 6 | BIM Distribuzione | false | false |
| 29 | 25 | Alexandra | $7,628 | -20.2% | 7 | +2 | $1,089 | $41,162 | 3 | N/A | false | false |
| 30 | 31 | The Wind Blows Round | $5,652 | +9.7% | 2 | - | $2,826 | $633,725 | 59 | Aranciafilm | false | false |
| 31 | 22 | Non pensarci | $5,587 | -71.8% | 2 | -8 | $2,793 | $2,111,760 | 11 | 01 Distribution | false | false |
| 32 | - | Tutto torna | $4,971 | - | 2 | - | $2,485 | $78,155 | 6 | N/A | false | false |
| 33 | 27 | Juno | $4,797 | -34.6% | 1 | -4 | $4,797 | $2,939,823 | 11 | 20th Century Fox International | false | false |
| 34 | 20 | The Other Boleyn Girl | $4,217 | -80.3% | 8 | -15 | $527 | $2,066,119 | 8 | Universal Pictures International (UPI) | false | false |
| 35 | 33 | Tutta la vita davanti | $3,639 | -23.2% | 3 | - | $1,213 | $5,875,793 | 12 | Medusa Distribuzione | false | false |
| 36 | 28 | Leatherheads | $3,509 | -51.2% | 1 | -3 | $3,509 | $3,490,813 | 10 | Universal Pictures International (UPI) | false | false |
| 37 | 29 | Underdog | $2,815 | -57.4% | 4 | -3 | $703 | $71,877 | 5 | Walt Disney Pictures | false | false |
| 38 | 24 | Be Kind Rewind | $2,697 | -75% | 3 | -5 | $899 | $203,496 | 4 | BIM Distribuzione | false | false |
| 39 | 23 | The Kite Runner | $1,873 | -87.9% | 3 | -11 | $624 | $12,414,004 | 12 | Filmauro | false | false |
| 40 | 47 | When Darkness Falls 2008 Re-release | $1,491 | -29.4% | 1 | - | $1,491 | $218,530 | 7 | Teodora Film | false | false |
| 41 | 44 | Nim's Island | $1,350 | -38.4% | 1 | -2 | $1,350 | $3,979,766 | 10 | Moviemax | false | false |
| 42 | - | Love Is Not Enough | $1,328 | - | 1 | - | $1,328 | $698,276 | 9 | Mediafilm | false | false |
| 43 | 41 | The Early Bird Catches the Worm | $959 | -63.4% | 1 | - | $959 | $1,456,159 | 16 | Medusa Distribuzione | false | false |
| 44 | - | There Will Be Blood | $889 | - | 1 | - | $889 | $2,566,966 | 18 | Walt Disney Pictures | false | false |
| 45 | - | Gone Baby Gone | $879 | - | 2 | - | $439 | $115,103 | 11 | Walt Disney Pictures | false | false |
| 46 | 21 | Maradona by Kusturica | $872 | -95.6% | 2 | -26 | $436 | $156,315 | 3 | BIM Distribuzione | false | false |
| 47 | - | Speed Racer | $863 | - | 1 | - | $863 | $756,653 | 6 | Warner Bros. | false | false |
| 48 | - | No Country for Old Men | $829 | - | 1 | - | $829 | $8,822,434 | 17 | Universal Pictures International (UPI) | false | false |
| 49 | 38 | The Fox and the Child | $827 | -74% | 3 | -4 | $275 | $2,301,544 | 13 | Lucky Red | false | false |
