| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Indiana Jones and the Kingdom of the Crystal Skull | $451,190 | -24.4% | 141 | - | $3,199 | $2,334,147 | 3 | United International Pictures | false | false |
| 2 | - | Cassandra's Dream | $174,195 | - | 30 | - | $5,806 | $174,195 | 1 | Alfa Films | true | false |
| 3 | 2 | Speed Racer | $152,776 | -14.1% | 94 | +5 | $1,625 | $2,012,321 | 5 | Warner Bros. | false | false |
| 4 | - | The Mist | $137,119 | - | 31 | - | $4,423 | $137,119 | 1 | Distribution Company | true | false |
| 5 | - | Made of Honor | $118,392 | - | 30 | - | $3,946 | $118,392 | 1 | Sony Pictures Releasing | true | false |
| 6 | 4 | What Happens in Vegas | $86,243 | -13.4% | 30 | - | $2,874 | $558,769 | 4 | 20th Century Fox International | false | false |
| 7 | 6 | Death at a Funeral | $81,255 | -8.8% | 33 | - | $2,462 | $1,912,688 | 14 | - | false | false |
| 8 | 3 | 88 Minutes | $72,586 | -37.6% | 31 | - | $2,341 | $215,377 | 2 | Distribution Company | false | false |
| 9 | 8 | The Oxford Murders | $58,379 | +2% | 23 | - | $2,538 | $494,817 | 5 | Pachamama Cine | false | false |
| 10 | 7 | Iron Man | $43,259 | -29% | 59 | -23 | $733 | $1,569,800 | 6 | United International Pictures | false | false |
| 11 | 9 | The Counterfeiters | $38,020 | -25.6% | 22 | - | $1,728 | $310,123 | 4 | Alfa Films | false | false |
| 12 | 10 | Awake | $30,615 | -23.9% | 31 | +1 | $987 | $250,182 | 4 | Distribution Company | false | false |
| 13 | 12 | The Nest | $25,571 | -18.7% | 36 | -1 | $710 | $969,462 | 7 | Distribution Company | false | false |
| 14 | 13 | Shutter | $24,542 | -16.5% | 25 | - | $981 | $463,150 | 8 | 20th Century Fox International | false | false |
| 15 | 14 | 21 | $19,394 | -27.4% | 29 | -6 | $668 | $716,477 | 8 | Sony Pictures Releasing | false | false |
| 16 | - | Heartbeat Detector | $14,458 | - | 3 | - | $4,819 | $14,458 | 1 | Zeta Films | true | false |
| 17 | 11 | The Unknown Woman | $14,315 | -61.4% | 16 | -3 | $894 | $138,976 | 3 | Impacto Cine | false | false |
| 18 | 18 | In the Valley of Elah | $12,627 | +3.8% | 12 | +2 | $1,052 | $320,528 | 10 | Alfa Films | false | false |
| 19 | 16 | Conversations with My Gardener | $12,488 | -33.7% | 11 | -1 | $1,135 | $205,585 | 7 | Alfa Films | false | false |
| 20 | 29 | Lamb of God | $12,386 | +261.8% | 13 | +7 | $952 | $142,736 | 5 | Alfa Films | false | false |
| 21 | 15 | Love by Accident | $7,865 | -65.1% | 8 | -10 | $983 | $37,300 | 2 | Primer Plano Film Group | false | false |
| 22 | 19 | Mrs Palfrey at the Claremont 2008 Re-release | $6,716 | -30.9% | 3 | - | $2,238 | $56,698 | 4 | Primer Plano Film Group | false | false |
| 23 | 21 | Street Kings | $5,966 | -3.6% | 19 | - | $314 | $244,116 | 7 | 20th Century Fox International | false | false |
| 24 | 25 | Two Days in Paris | $5,481 | +48.9% | 5 | +1 | $1,096 | $370,886 | 11 | Impacto Cine | false | false |
| 25 | 17 | Odette Toulemonde | $4,986 | -71.8% | 6 | -2 | $831 | $26,823 | 2 | Notro Films | false | false |
| 26 | - | No ser Dios y cuidarlos | $3,523 | - | 3 | - | $1,174 | $3,523 | 1 | Primer Plano Film Group | true | false |
| 27 | 26 | The Savages | $3,494 | -3% | 11 | +1 | $317 | $117,002 | 6 | 20th Century Fox International | false | false |
| 28 | 23 | Untraceable | $3,151 | -34.6% | 6 | - | $525 | $200,502 | 7 | Sony Pictures Releasing | false | false |
| 29 | 22 | Yo soy sola | $2,941 | -43.6% | 5 | -1 | $588 | $38,523 | 4 | Alfa Films | false | false |
| 30 | 30 | The Orphanage | $2,520 | -5.5% | 4 | -2 | $630 | $750,843 | 13 | CDI Films | false | false |
| 31 | 34 | Caramel | $2,157 | +27% | 3 | -2 | $719 | $227,788 | 11 | Alfa Films | false | false |
| 32 | 28 | P.S. I Love You | $1,461 | -58.9% | 4 | -3 | $365 | $463,222 | 15 | Alfa Films | false | false |
| 33 | 33 | Mr. Woodcock | $1,451 | -16.1% | 3 | +1 | $483 | $106,745 | 10 | Distribution Company | false | false |
| 34 | 35 | The Game Plan | $1,414 | -13.4% | 7 | -2 | $202 | $1,500,431 | 17 | Walt Disney Pictures | false | false |
| 35 | - | U2 3D | $1,280 | - | 1 | - | $1,280 | $154,404 | 11 | IMAX | false | false |
| 36 | 20 | We Own the Night | $1,097 | -82.3% | 3 | -5 | $365 | $86,643 | 6 | CDI Films | false | false |
| 37 | 32 | Evening | $1,026 | -44.2% | 6 | +3 | $171 | $192,765 | 9 | Impacto Cine | false | false |
| 38 | 37 | The Ugly Duckling and Me! | $747 | +6.3% | 5 | +2 | $149 | $78,438 | 12 | - | false | false |
| 39 | 40 | Lust, Caution | $672 | +26.1% | 1 | -1 | $672 | $61,126 | 6 | Distribution Company | false | false |
| 40 | 27 | King of California | $594 | -83.4% | 2 | -3 | $297 | $72,016 | 9 | Distribution Company | false | false |
| 41 | - | Twice Upon a Time | $406 | - | 1 | - | $406 | $110,611 | 8 | Pachamama Cine | false | false |
| 42 | 38 | The Spiderwick Chronicles | $393 | -42.8% | 3 | -4 | $131 | $685,342 | 12 | United International Pictures | false | false |
| 43 | 43 | No Country for Old Men | $366 | +95.7% | 1 | -1 | $366 | $997,948 | 14 | Walt Disney Pictures | false | false |
| 44 | - | The Hunting Party | $362 | - | 2 | - | $181 | $317,405 | 12 | Distribution Company | false | false |
| 45 | 42 | 10,000 BC | $361 | +38.8% | 2 | - | $180 | $2,262,455 | 14 | Warner Bros. | false | false |
| 46 | 39 | Jumper | $297 | -45.6% | 2 | -5 | $148 | $614,185 | 10 | 20th Century Fox International | false | false |
| 47 | - | Gone Baby Gone | $169 | - | 1 | - | $169 | $436,926 | 29 | Walt Disney Pictures | false | false |
| 48 | - | There Will Be Blood | $118 | - | 1 | - | $118 | $520,135 | 16 | Walt Disney Pictures | false | false |
| 49 | - | Shine a Light | $72 | - | 1 | - | $72 | $99,492 | 9 | Distribution Company | false | false |
| 50 | - | Silk | $69 | - | 1 | - | $69 | $11,485 | 5 | Distribution Company | false | false |
| 51 | 45 | Alvin and the Chipmunks | $67 | -33.7% | 1 | - | $67 | $823,586 | 23 | 20th Century Fox International | false | false |
| 52 | 46 | The Water Horse | $60 | -22.1% | 1 | - | $60 | $608,719 | 18 | Sony Pictures Releasing | false | false |
| 53 | 47 | Enchanted | $55 | -11.3% | 1 | - | $55 | $2,862,003 | 23 | Walt Disney Pictures | false | false |
| 54 | 49 | Underdog | $20 | -35.5% | 1 | - | $20 | $878,282 | 36 | Walt Disney Pictures | false | false |
| 55 | - | Juno | $13 | - | 1 | - | $13 | $478,344 | 17 | Alfa Films | false | false |
| 56 | 36 | S.O.S. Ex | $13 | -99% | 1 | -2 | $13 | $8,731 | 4 | N/A | false | false |
| 57 | - | Atonement | $7 | - | 1 | - | $7 | $528,237 | 18 | United International Pictures | false | false |
