| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Indiana Jones and the Kingdom of the Crystal Skull | $1,125,148 | -29.3% | 132 | -1 | $8,523 | $3,149,468 | 2 | Universal Pictures International (UPI) | false | false |
| 2 | 2 | What Happens in Vegas | $453,084 | -11.4% | 93 | - | $4,871 | $2,665,612 | 4 | Warner Bros. | false | false |
| 3 | 3 | Iron Man | $104,679 | -24.6% | 75 | - | $1,395 | $1,865,372 | 5 | Universal Pictures International (UPI) | false | false |
| 4 | 4 | Dunya & Desie | $80,857 | -10.4% | 75 | - | $1,078 | $1,969,597 | 7 | Independent Films | false | false |
| 5 | 5 | Taken | $78,857 | -1.3% | 35 | - | $2,253 | $726,904 | 5 | Independent Films | false | false |
| 6 | 6 | Over Her Dead Body | $67,308 | +3.3% | 20 | - | $3,365 | $193,813 | 2 | RCV Film Distribution | false | false |
| 7 | 7 | Into the Wild | $64,796 | +0.4% | 23 | - | $2,817 | $672,696 | 6 | A-Film Distribution | false | false |
| 8 | 9 | Happy-Go-Lucky | $44,719 | -12.8% | 21 | - | $2,129 | $215,190 | 3 | RCV Film Distribution | false | false |
| 9 | 8 | Fool's Gold | $42,684 | -19.2% | 39 | - | $1,094 | $771,682 | 5 | Warner Bros. | false | false |
| 10 | - | All the Boys Love Mandy Lane | $41,992 | - | 15 | - | $2,799 | $73,891 | 1 | Moonlight Films | true | false |
| 11 | 10 | Morrison krijgt een zusje | $35,514 | -27.6% | 85 | - | $417 | $514,256 | 6 | Warner Bros. | false | false |
| 12 | - | Leatherheads | $29,712 | - | 15 | - | $1,980 | $34,838 | 1 | Universal Pictures International (UPI) | true | false |
| 13 | 11 | Winx Club: The Secret of the Lost Kingdom | $28,997 | -17.7% | 105 | -2 | $276 | $615,329 | 7 | Independent Films | false | false |
| 14 | 12 | Horton Hears a Who! | $22,776 | -30.5% | 69 | -5 | $330 | $1,922,180 | 11 | Warner Bros. | false | false |
| 15 | - | Funny Games | $19,739 | - | 14 | - | $1,409 | $45,316 | 1 | Cinéart | true | false |
| 16 | 13 | Be Kind Rewind | $19,237 | -35% | 16 | - | $1,202 | $160,196 | 3 | A-Film Distribution | false | false |
| 17 | 14 | The Orphanage | $17,783 | -35.9% | 14 | - | $1,270 | $88,565 | 2 | A-Film Distribution | false | false |
| 18 | 17 | Elite Squad | $15,040 | -13.4% | 15 | - | $1,002 | $56,708 | 2 | Benelux Film Distributors | false | false |
| 19 | 15 | Dragon Hunters | $14,813 | -28% | 56 | +2 | $264 | $203,545 | 6 | Independent Films | false | false |
| 20 | 18 | The Bucket List | $13,452 | -21.7% | 29 | +6 | $463 | $1,325,290 | 10 | Warner Bros. | false | false |
| 21 | 21 | Vantage Point | $1,736 | -80.4% | 9 | -4 | $192 | $1,084,241 | 8 | Sony Pictures Releasing | false | false |
