| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Indiana Jones and the Kingdom of the Crystal Skull | $5,507,994 | -41% | 532 | -3 | $10,353 | $17,331,069 | 2 | Paramount Pictures International | false | false |
| 2 | 3 | What Happens in Vegas | $1,015,039 | -9.8% | 277 | -13 | $3,664 | $8,019,639 | 4 | 20th Century Fox International | false | false |
| 3 | 2 | Iron Man | $992,103 | -16.8% | 288 | -47 | $3,444 | $17,185,852 | 5 | Paramount Pictures International | false | false |
| 4 | 4 | 21 | $700,992 | -10.4% | 190 | -1 | $3,689 | $3,662,464 | 3 | Sony Pictures Releasing | false | false |
| 5 | 5 | Made of Honor | $330,713 | -6.6% | 183 | -38 | $1,807 | $4,880,827 | 5 | Sony Pictures Releasing | false | false |
| 6 | 6 | Shutter | $207,896 | -11% | 74 | +2 | $2,809 | $1,040,124 | 3 | 20th Century Fox International | false | false |
| 7 | 8 | The Painted Veil | $187,342 | +12.5% | 63 | +10 | $2,973 | $2,437,005 | 6 | Paramount Pictures International | false | false |
| 8 | 7 | Then She Found Me | $185,910 | -11.3% | 55 | +1 | $3,380 | $1,000,467 | 3 | Hopscotch Films | false | false |
| 9 | 12 | Playground | $145,633 | +60.6% | 3 | +1 | $48,544 | $250,155 | 2 | - | false | false |
| 10 | - | Shine a Light | $134,738 | - | 28 | - | $4,812 | $222,766 | 1 | 20th Century Fox International | true | false |
| 11 | 9 | The Counterfeiters | $132,942 | -8.7% | 37 | +4 | $3,593 | $772,037 | 4 | Madman Entertainment | false | false |
| 12 | - | The Orphanage | $116,394 | - | 21 | - | $5,542 | $141,832 | 1 | Roadshow Films | true | false |
| 13 | 10 | Forgetting Sarah Marshall | $90,340 | -11.1% | 70 | -12 | $1,290 | $6,396,163 | 7 | Universal Pictures International (UPI) | false | false |
| 14 | - | Leatherheads | $86,446 | - | 40 | - | $2,161 | $86,446 | 1 | Universal Pictures International (UPI) | true | false |
| 15 | 11 | Miss Pettigrew Lives for a Day | $77,837 | -15.3% | 64 | -7 | $1,216 | $907,720 | 4 | Roadshow Films | false | false |
| 16 | 14 | A Secret | $62,483 | -6.1% | 22 | +2 | $2,840 | $326,364 | 3 | Icon Film Distribution | false | false |
| 17 | 17 | Gone Baby Gone | $53,073 | +21.7% | 17 | -19 | $3,121 | $1,251,576 | 7 | Walt Disney Pictures | false | false |
| 18 | 13 | Love in the Time of Cholera | $50,552 | -34.5% | 47 | -2 | $1,075 | $163,554 | 2 | Rialto Distribution | false | false |
| 19 | 16 | Lars and the Real Girl | $48,898 | +6.9% | 35 | +8 | $1,397 | $1,222,715 | 9 | Rialto Distribution | false | false |
| 20 | 15 | Nim's Island | $43,701 | -23.2% | 73 | -12 | $598 | $5,768,602 | 9 | Universal Pictures International (UPI) | false | false |
| 21 | 19 | The Edge of Heaven | $33,470 | -10.7% | 17 | - | $1,968 | $519,794 | 6 | Sharmill Films | false | false |
| 22 | 30 | Black Water | $25,463 | +425% | 10 | +3 | $2,546 | $81,440 | 6 | All Interactive Distribution | false | false |
| 23 | 18 | U2 3D | $24,095 | -38.9% | 3 | - | $8,031 | $1,267,350 | 8 | Roadshow Films | false | false |
| 24 | 22 | The Black Balloon | $21,399 | -1.5% | 9 | -27 | $2,377 | $2,120,887 | 13 | Icon Film Distribution | false | false |
| 25 | 24 | The Spiderwick Chronicles | $17,926 | -4.3% | 35 | - | $512 | $7,328,931 | 9 | Paramount Pictures International | false | false |
| 26 | 23 | Before the Devil Knows You're Dead | $16,556 | -20.2% | 22 | -5 | $752 | $1,491,724 | 11 | Hopscotch Films | false | false |
| 27 | 20 | Sharkwater | $16,418 | -36% | 19 | -23 | $864 | $130,096 | 3 | Walt Disney Pictures | false | false |
| 28 | - | Earth | $16,079 | - | 5 | - | $3,215 | $16,607 | 1 | Hoyts Distribution | true | false |
| 29 | 25 | Deception | $15,075 | -11.7% | 21 | +2 | $717 | $1,431,644 | 6 | 20th Century Fox International | false | false |
| 30 | 27 | Molière | $13,724 | +13.8% | 14 | - | $980 | $329,342 | 5 | Hopscotch Films | false | false |
| 31 | 26 | Horton Hears a Who! | $10,520 | -18.7% | 29 | -9 | $362 | $11,197,828 | 11 | 20th Century Fox International | false | false |
| 32 | - | Flight of the Red Balloon | $10,131 | - | 4 | - | $2,532 | $13,065 | 1 | Madman Entertainment | true | false |
| 33 | 28 | Street Kings | $8,206 | -31% | 11 | -12 | $746 | $3,856,874 | 7 | 20th Century Fox International | false | false |
| 34 | 21 | Goal II: Living the Dream | $7,654 | -64.9% | 15 | -26 | $510 | $38,700 | 2 | Roadshow Films | false | false |
| 35 | 29 | Paris | $6,831 | +23% | 11 | - | $621 | $694,041 | 8 | Icon Film Distribution | false | false |
| 36 | 33 | Brick Lane | $5,555 | +72.1% | 4 | -3 | $1,388 | $615,896 | 11 | Madman Entertainment | false | false |
| 37 | 36 | The Other Boleyn Girl | $5,138 | +91.3% | 15 | +3 | $342 | $3,915,410 | 12 | Universal Pictures International (UPI) | false | false |
| 38 | 32 | Step Up 2: The Streets | $4,210 | +26.2% | 8 | -1 | $526 | $8,657,437 | 11 | Universal Pictures International (UPI) | false | false |
| 39 | 49 | Never Back Down | $3,823 | +2,731.9% | 13 | +12 | $294 | $3,037,979 | 10 | Roadshow Films | false | false |
| 40 | 45 | In the Shadow of the Moon | $3,287 | +241% | 5 | +2 | $657 | $376,147 | 13 | Madman Entertainment | false | false |
| 41 | 44 | Cactus | $2,623 | +36% | 7 | -4 | $374 | $151,184 | 5 | Hoyts Distribution | false | false |
| 42 | - | No Country for Old Men | $2,109 | - | 4 | - | $527 | $5,625,870 | 24 | Paramount Pictures International | false | false |
| 43 | 40 | The Bucket List | $1,314 | -44.9% | 7 | -2 | $187 | $7,515,672 | 15 | Warner Bros. | false | false |
| 44 | 42 | 120 | $1,063 | -51.7% | 1 | -1 | $1,063 | $54,243 | 8 | N/A | false | false |
| 45 | 39 | Closing the Ring | $873 | -65.3% | 4 | -4 | $218 | $380,552 | 13 | Hopscotch Films | false | false |
| 46 | 41 | Semi-Pro | $840 | -62.2% | 3 | -1 | $280 | $3,890,603 | 9 | Roadshow Films | false | false |
| 47 | 31 | Bhoothnath | $686 | -82.3% | 2 | -4 | $343 | $54,372 | 4 | Eros Worldwide | false | false |
| 48 | 43 | Be Kind Rewind | $281 | -86.7% | 5 | - | $56 | $914,786 | 11 | Roadshow Films | false | false |
| 49 | 47 | Run Fatboy Run | $265 | -26.2% | 3 | -1 | $88 | $3,196,789 | 13 | Roadshow Films | false | false |
| 50 | 38 | Superhero Movie | $232 | -91% | 2 | -6 | $116 | $3,277,834 | 8 | Roadshow Films | false | false |
