| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Indiana Jones and the Kingdom of the Crystal Skull | $596,957 | -33.5% | 141 | +56 | $4,233 | $1,714,542 | 2 | United International Pictures | false | false |
| 2 | 2 | Speed Racer | $177,956 | -26.1% | 89 | -2 | $1,999 | $1,703,397 | 4 | Warner Bros. | false | false |
| 3 | - | 88 Minutes | $116,400 | - | 31 | - | $3,754 | $116,400 | 1 | Distribution Company | true | false |
| 4 | 3 | What Happens in Vegas | $99,553 | -19.6% | 30 | - | $3,318 | $448,138 | 3 | 20th Century Fox International | false | false |
| 5 | - | Leonera | $91,258 | - | 24 | - | $3,802 | $91,258 | 1 | Walt Disney Pictures | true | false |
| 6 | 5 | Death at a Funeral | $89,056 | -6.8% | 33 | - | $2,698 | $1,794,899 | 13 | Compañía General de la Imagen (CGI) | false | false |
| 7 | 4 | Iron Man | $60,931 | -37.1% | 82 | +1 | $743 | $1,495,657 | 5 | United International Pictures | false | false |
| 8 | 7 | The Oxford Murders | $57,261 | -17.4% | 23 | - | $2,489 | $417,674 | 4 | Pachamama Cine | false | false |
| 9 | 6 | The Counterfeiters | $51,077 | -33.4% | 22 | - | $2,321 | $255,894 | 3 | Alfa Films | false | false |
| 10 | 9 | Awake | $40,247 | -27.5% | 30 | -1 | $1,341 | $208,525 | 3 | Distribution Company | false | false |
| 11 | 8 | The Unknown Woman | $37,130 | -40.4% | 19 | - | $1,954 | $115,265 | 2 | Impacto Cine | false | false |
| 12 | 10 | The Nest | $31,446 | -43.1% | 37 | -1 | $849 | $921,005 | 6 | Distribution Company | false | false |
| 13 | 12 | Shutter | $29,380 | -10.2% | 25 | -2 | $1,175 | $449,067 | 7 | 20th Century Fox International | false | false |
| 14 | 11 | 21 | $26,706 | -28.4% | 35 | -2 | $763 | $702,354 | 7 | Sony Pictures Releasing | false | false |
| 15 | - | Love by Accident | $22,510 | - | 18 | - | $1,250 | $22,510 | 1 | Primer Plano Film Group | true | false |
| 16 | 16 | Conversations with My Gardener | $18,829 | +76.1% | 12 | +4 | $1,569 | $185,257 | 6 | Alfa Films | false | false |
| 17 | - | Odette Toulemonde | $17,652 | - | 8 | - | $2,206 | $17,652 | 1 | Notro Films | true | false |
| 18 | 29 | In the Valley of Elah | $12,162 | +428.8% | 10 | +5 | $1,216 | $301,791 | 9 | Alfa Films | false | false |
| 19 | 15 | Mrs Palfrey at the Claremont 2008 Re-release | $9,718 | -23.1% | 3 | - | $3,239 | $47,175 | 3 | Primer Plano Film Group | false | false |
| 20 | 20 | We Own the Night | $6,196 | +21% | 8 | - | $774 | $83,213 | 5 | CDI Films | false | false |
| 21 | 14 | Street Kings | $6,186 | -52% | 19 | -11 | $325 | $232,281 | 6 | 20th Century Fox International | false | false |
| 22 | 17 | Yo soy sola | $5,215 | -16.5% | 6 | - | $869 | $34,174 | 3 | Alfa Films | false | false |
| 23 | 24 | Untraceable | $4,815 | +42% | 6 | - | $802 | $189,285 | 6 | Sony Pictures Releasing | false | false |
| 24 | 19 | Horton Hears a Who! | $3,941 | -23.7% | 9 | -3 | $437 | $1,222,741 | 12 | 20th Century Fox International | false | false |
| 25 | 18 | Two Days in Paris | $3,680 | -33.5% | 4 | -4 | $920 | $360,969 | 10 | Impacto Cine | false | false |
| 26 | 21 | The Savages | $3,602 | -23.4% | 10 | +3 | $360 | $111,148 | 5 | 20th Century Fox International | false | false |
| 27 | 42 | King of California | $3,587 | +722.7% | 5 | +3 | $717 | $69,583 | 8 | Distribution Company | false | false |
| 28 | 22 | P.S. I Love You | $3,555 | -13.8% | 7 | -2 | $507 | $456,982 | 14 | Alfa Films | false | false |
| 29 | 13 | Lamb of God | $3,423 | -78.9% | 6 | -4 | $570 | $128,211 | 4 | Alfa Films | false | false |
| 30 | 23 | The Orphanage | $2,667 | -25.8% | 6 | -7 | $444 | $740,431 | 12 | CDI Films | false | false |
| 31 | 27 | Persepolis | $2,133 | -24.2% | 2 | -2 | $1,066 | $43,912 | 6 | Sony Pictures Releasing | false | false |
| 32 | 25 | Evening | $1,840 | -45.2% | 3 | -6 | $613 | $189,273 | 8 | Impacto Cine | false | false |
| 33 | 35 | Mr. Woodcock | $1,730 | +86% | 2 | -4 | $865 | $104,112 | 9 | Distribution Company | false | false |
| 34 | 26 | Caramel | $1,698 | -46.1% | 5 | -1 | $339 | $222,470 | 10 | Alfa Films | false | false |
| 35 | 32 | The Game Plan | $1,633 | +14.7% | 9 | -1 | $181 | $1,485,059 | 16 | Walt Disney Pictures | false | false |
| 36 | 28 | S.O.S. Ex | $1,347 | -45.6% | 3 | - | $449 | $7,974 | 3 | N/A | false | false |
| 37 | 41 | The Ugly Duckling and Me! | $703 | +47.1% | 3 | -2 | $234 | $77,063 | 11 | - | false | false |
| 38 | 39 | The Spiderwick Chronicles | $687 | +0.7% | 7 | - | $98 | $675,111 | 11 | United International Pictures | false | false |
| 39 | 31 | Jumper | $546 | -75.4% | 7 | -11 | $78 | $587,316 | 9 | 20th Century Fox International | false | false |
| 40 | 30 | Lust, Caution | $533 | -76.8% | 2 | -3 | $266 | $59,722 | 5 | Distribution Company | false | false |
| 41 | 34 | El desierto negro | $417 | -55.8% | 1 | -1 | $417 | $7,232 | 3 | N/A | false | false |
| 42 | 37 | 10,000 BC | $260 | -63.8% | 2 | -3 | $130 | $2,240,764 | 13 | Warner Bros. | false | false |
| 43 | 38 | No Country for Old Men | $187 | -72.9% | 2 | -3 | $93 | $979,949 | 13 | Walt Disney Pictures | false | false |
| 44 | 33 | Elizabeth: The Golden Age | $165 | -87.8% | 1 | -2 | $165 | $110,682 | 12 | United International Pictures | false | false |
| 45 | 46 | Alvin and the Chipmunks | $101 | -46% | 1 | -2 | $101 | $816,193 | 22 | 20th Century Fox International | false | false |
| 46 | 50 | The Water Horse | $77 | +2.7% | 1 | - | $77 | $590,753 | 17 | Sony Pictures Releasing | false | false |
| 47 | 53 | Enchanted | $62 | +63.2% | 1 | - | $62 | $2,861,960 | 22 | Walt Disney Pictures | false | false |
| 48 | 43 | Diary of the Dead | $54 | -79.6% | 1 | -1 | $54 | $296,292 | 11 | Pachamama Cine | false | false |
| 49 | 49 | Underdog | $31 | -65.6% | 1 | -1 | $31 | $869,983 | 35 | Walt Disney Pictures | false | false |
