| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Indiana Jones and the Kingdom of the Crystal Skull | $9,331,156 | - | 535 | - | $17,441 | $9,331,156 | 1 | Paramount Pictures International | true | false |
| 2 | 1 | Iron Man | $1,192,160 | -50.2% | 335 | -30 | $3,558 | $15,974,894 | 4 | Paramount Pictures International | false | false |
| 3 | 2 | What Happens in Vegas | $1,125,657 | -41.7% | 290 | -45 | $3,881 | $6,733,618 | 3 | 20th Century Fox International | false | false |
| 4 | 3 | 21 | $781,961 | -46.9% | 191 | - | $4,094 | $2,711,837 | 2 | Sony Pictures Releasing | false | false |
| 5 | 4 | Made of Honor | $354,107 | -41% | 221 | -31 | $1,602 | $4,446,814 | 4 | Sony Pictures Releasing | false | false |
| 6 | 5 | Shutter | $233,693 | -42.6% | 72 | - | $3,245 | $761,853 | 2 | 20th Century Fox International | false | false |
| 7 | 6 | Then She Found Me | $209,478 | -32.3% | 54 | - | $3,879 | $725,674 | 2 | Hopscotch Films | false | false |
| 8 | 8 | The Painted Veil | $166,520 | -26% | 53 | -1 | $3,141 | $2,188,397 | 5 | Paramount Pictures International | false | false |
| 9 | 10 | The Counterfeiters | $145,689 | -10.2% | 33 | +14 | $4,414 | $585,994 | 3 | Madman Entertainment | false | false |
| 10 | 7 | Forgetting Sarah Marshall | $101,596 | -56.1% | 82 | -66 | $1,238 | $6,301,194 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | 9 | Miss Pettigrew Lives for a Day | $91,853 | -46.5% | 71 | - | $1,293 | $787,730 | 3 | Roadshow Films | false | false |
| 12 | - | Playground | $90,664 | - | 2 | - | $45,332 | $105,043 | 1 | - | true | false |
| 13 | - | Love in the Time of Cholera | $77,135 | - | 49 | - | $1,574 | $77,135 | 1 | Rialto Distribution | true | false |
| 14 | 13 | A Secret | $66,507 | -6.1% | 20 | +2 | $3,325 | $240,212 | 2 | Icon Film Distribution | false | false |
| 15 | 11 | Nim's Island | $56,890 | -48.3% | 85 | -51 | $669 | $5,746,753 | 8 | Universal Pictures International (UPI) | false | false |
| 16 | 14 | Lars and the Real Girl | $45,743 | -31.1% | 27 | -12 | $1,694 | $1,165,124 | 8 | Rialto Distribution | false | false |
| 17 | 12 | Gone Baby Gone | $43,618 | -42.8% | 36 | - | $1,211 | $1,185,751 | 6 | Walt Disney Pictures | false | false |
| 18 | 16 | U2 3D | $39,430 | -38.1% | 3 | -6 | $13,143 | $1,243,230 | 7 | Roadshow Films | false | false |
| 19 | 18 | The Edge of Heaven | $37,472 | -25.3% | 17 | +1 | $2,204 | $485,000 | 5 | Sharmill Films | false | false |
| 20 | 20 | Sharkwater | $25,637 | -45.3% | 42 | +1 | $610 | $102,442 | 2 | Walt Disney Pictures | false | false |
| 21 | - | Goal II: Living the Dream | $21,814 | - | 41 | - | $532 | $21,814 | 1 | Roadshow Films | true | false |
| 22 | 22 | The Black Balloon | $21,715 | -21.3% | 36 | -3 | $603 | $2,093,766 | 12 | Icon Film Distribution | false | false |
| 23 | 24 | Before the Devil Knows You're Dead | $20,750 | -17% | 27 | -2 | $768 | $1,471,937 | 10 | Hopscotch Films | false | false |
| 24 | 19 | The Spiderwick Chronicles | $18,725 | -61.2% | 35 | -43 | $535 | $7,549,675 | 8 | Paramount Pictures International | false | false |
| 25 | 15 | Deception | $17,082 | -74.1% | 19 | -36 | $899 | $1,415,366 | 5 | 20th Century Fox International | false | false |
| 26 | 23 | Horton Hears a Who! | $12,939 | -52.5% | 38 | -12 | $340 | $11,220,231 | 10 | 20th Century Fox International | false | false |
| 27 | 26 | Molière | $12,059 | -46.6% | 14 | -1 | $861 | $310,439 | 4 | Hopscotch Films | false | false |
| 28 | 17 | Street Kings | $11,894 | -80.9% | 23 | -42 | $517 | $3,856,921 | 6 | 20th Century Fox International | false | false |
| 29 | 28 | Paris | $5,555 | -53.9% | 11 | -4 | $505 | $583,243 | 7 | Icon Film Distribution | false | false |
| 30 | 32 | Black Water | $4,850 | -34.5% | 7 | - | $692 | $54,192 | 5 | All Interactive Distribution | false | false |
| 31 | 29 | Bhoothnath | $3,867 | -65.8% | 6 | -2 | $644 | $52,780 | 3 | Eros Worldwide | false | false |
| 32 | 27 | Step Up 2: The Streets | $3,337 | -82.5% | 9 | -22 | $370 | $8,682,725 | 10 | Universal Pictures International (UPI) | false | false |
| 33 | 34 | Brick Lane | $3,228 | -38.4% | 7 | -6 | $461 | $610,487 | 10 | Madman Entertainment | false | false |
| 34 | - | In the Valley of Elah | $3,064 | - | 9 | - | $340 | $572,768 | 13 | Hoyts Distribution | false | false |
| 35 | - | Flight of the Red Balloon | $2,934 | - | 2 | - | $1,467 | $2,934 | - | Madman Entertainment | - | false |
| 36 | 30 | The Other Boleyn Girl | $2,686 | -74.8% | 12 | -20 | $223 | $3,922,425 | 11 | Universal Pictures International (UPI) | false | false |
| 37 | 21 | Smother | $2,629 | -91.2% | 12 | -112 | $219 | $171,217 | 3 | Hoyts Distribution | false | false |
| 38 | 31 | Superhero Movie | $2,589 | -72.2% | 8 | -12 | $323 | $3,288,591 | 7 | Roadshow Films | false | false |
| 39 | 36 | Closing the Ring | $2,517 | -49.4% | 8 | -3 | $314 | $377,019 | 12 | Hopscotch Films | false | false |
| 40 | 40 | The Bucket List | $2,384 | -11.3% | 9 | -1 | $264 | $7,538,733 | 14 | Warner Bros. | false | false |
| 41 | 39 | Semi-Pro | $2,221 | -33.8% | 4 | -4 | $555 | $3,902,927 | 8 | Roadshow Films | false | false |
| 42 | 37 | 120 | $2,201 | -53.7% | 2 | - | $1,100 | $52,512 | 7 | N/A | false | false |
| 43 | 35 | Be Kind Rewind | $2,110 | -59.7% | 5 | -3 | $422 | $916,642 | 10 | Roadshow Films | false | false |
| 44 | 33 | Cactus | $1,929 | -70.5% | 11 | -17 | $175 | $148,143 | 4 | Hoyts Distribution | false | false |
| 45 | 43 | In the Shadow of the Moon | $964 | -48.4% | 3 | -3 | $321 | $373,540 | 12 | Madman Entertainment | false | false |
| 46 | - | Grand Canyon Adventure: River at Risk | $559 | - | 1 | - | $559 | $559 | - | IMAX | - | false |
| 47 | 42 | Run Fatboy Run | $359 | -81.7% | 4 | -2 | $89 | $3,205,955 | 12 | Roadshow Films | false | false |
| 48 | 41 | 10,000 BC | $141 | -93.8% | 2 | -7 | $70 | $6,276,216 | 12 | Warner Bros. | false | false |
| 49 | 38 | Never Back Down | $135 | -96.6% | 1 | -8 | $135 | $3,044,601 | 9 | Roadshow Films | false | false |
