| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | What Happens in Vegas | $2,322,631 | -38.6% | 408 | +10 | $5,692 | $7,051,586 | 2 | 20th Century Fox International | false | false |
| 2 | 2 | Iron Man | $1,053,993 | -48.3% | 529 | -11 | $1,992 | $10,168,422 | 3 | Sony Pictures Releasing | false | false |
| 3 | - | Prom Night | $642,659 | - | 228 | - | $2,818 | $674,597 | 1 | Sony Pictures Releasing | true | false |
| 4 | 4 | 88 Minutes | $455,605 | -31.1% | 171 | +1 | $2,664 | $2,622,836 | 3 | Filmax | false | false |
| 5 | - | Death Sentence | $424,712 | - | 134 | - | $3,169 | $451,780 | 1 | TriPictures | true | false |
| 6 | 3 | Speed Racer | $423,551 | -51.4% | 394 | -33 | $1,075 | $1,497,443 | 2 | Warner Bros. | false | false |
| 7 | 6 | Chef's Special | $409,339 | -23.5% | 219 | -8 | $1,869 | $6,410,921 | 6 | Warner Bros. | false | false |
| 8 | 5 | Street Kings | $347,087 | -39.2% | 255 | -42 | $1,361 | $3,568,652 | 4 | 20th Century Fox International | false | false |
| 9 | 7 | Casual Day | $270,471 | -37.6% | 120 | - | $2,253 | $865,382 | 2 | Walt Disney Pictures | false | false |
| 10 | 8 | 21 | $250,302 | -34.2% | 190 | -19 | $1,317 | $6,285,375 | 6 | Sony Pictures Releasing | false | false |
| 11 | 10 | Elegy | $221,553 | -30.2% | 121 | -4 | $1,831 | $3,160,275 | 5 | On Pictures | false | false |
| 12 | - | Drillbit Taylor | $185,856 | - | 112 | - | $1,659 | $193,996 | 1 | Universal Pictures International (UPI) | true | false |
| 13 | 9 | Fool's Gold | $163,284 | -49.7% | 216 | -49 | $755 | $2,755,046 | 4 | Warner Bros. | false | false |
| 14 | - | Island of Lost Souls | $146,839 | - | 59 | - | $2,488 | $164,667 | 1 | - | true | false |
| 15 | - | A Girl Cut in Two | $139,534 | - | 37 | - | $3,771 | $154,858 | 1 | Wanda Visión S.A. | true | false |
| 16 | 13 | The Game Plan | $110,921 | -42.5% | 166 | -17 | $668 | $5,573,211 | 8 | Walt Disney Pictures | false | false |
| 17 | 12 | Cowards | $82,594 | -59.8% | 119 | -81 | $694 | $1,354,348 | 4 | Filmax | false | false |
| 18 | 16 | A Thousand Years of Good Prayers | $81,705 | -27.7% | 37 | +1 | $2,208 | $857,668 | 5 | Karma Films | false | false |
| 19 | 11 | My Mom's New Boyfriend | $75,071 | -66.6% | 130 | -70 | $577 | $1,234,707 | 3 | DeAPlaneta | false | false |
| 20 | 14 | Horton Hears a Who! | $72,068 | -41.8% | 138 | -17 | $522 | $10,777,358 | 10 | 20th Century Fox International | false | false |
| 21 | - | Sultanes del Sur | $61,358 | - | 30 | - | $2,045 | $66,742 | 1 | Filmax | true | false |
| 22 | 20 | Late Bloomers | $61,072 | -15.1% | 18 | +1 | $3,392 | $171,352 | 2 | - | false | false |
| 23 | - | La crisis carnívora | $56,976 | - | 84 | - | $678 | $58,950 | 1 | - | true | false |
| 24 | 15 | Shutter | $56,921 | -53.1% | 77 | -27 | $739 | $3,635,204 | 6 | 20th Century Fox International | false | false |
| 25 | 18 | 8 Dates | $46,917 | -42.3% | 49 | -15 | $957 | $1,217,865 | 5 | Alta Films | false | false |
| 26 | 22 | The Counterfeiters | $45,159 | -11.8% | 33 | -8 | $1,368 | $3,670,582 | 10 | Wanda Visión S.A. | false | false |
| 27 | 19 | Rudy: The Return of the Racing Pig | $41,543 | -42.6% | 48 | -3 | $865 | $264,673 | 4 | - | false | false |
| 28 | 23 | Definitely, Maybe | $30,435 | -38.3% | 26 | -15 | $1,170 | $235,285 | 2 | Universal Pictures International (UPI) | false | false |
| 29 | 27 | The Savages | $29,412 | -27.6% | 27 | -1 | $1,089 | $855,706 | 7 | 20th Century Fox International | false | false |
| 30 | 17 | Shattered | $28,023 | -66.3% | 51 | -47 | $549 | $425,278 | 3 | Manga Entertainment | false | false |
| 31 | 32 | The Band's Visit | $25,581 | -4.7% | 19 | +6 | $1,346 | $371,117 | 6 | Manga Entertainment | false | false |
| 32 | 31 | The Edge of Heaven | $24,598 | -24.3% | 22 | +2 | $1,118 | $1,156,030 | 10 | Golem Distribución | false | false |
| 33 | 21 | A Tram in SP | $23,190 | -55.2% | 41 | -5 | $565 | $230,166 | 3 | - | false | false |
| 34 | 28 | Be Kind Rewind | $22,854 | -35.4% | 10 | -3 | $2,285 | $427,271 | 6 | Universal Pictures International (UPI) | false | false |
| 35 | 30 | The Duchess of Langeais | $22,652 | -34.5% | 10 | - | $2,265 | $135,752 | 3 | Baditri | false | false |
| 36 | 34 | Lars and the Real Girl | $22,463 | -11.6% | 12 | - | $1,871 | $180,974 | 4 | Versus Entertainment | false | false |
| 37 | 24 | Never Back Down | $21,358 | -56.4% | 50 | -31 | $427 | $1,611,533 | 5 | - | false | false |
| 38 | - | Honeydripper | $21,277 | - | 6 | - | $3,546 | $22,687 | 1 | Golem Distribución | true | false |
| 39 | 26 | Todos estamos invitados | $20,434 | -51.3% | 28 | -10 | $729 | $1,197,901 | 6 | Alta Films | false | false |
| 40 | 33 | Days of Darkness | $19,605 | -23.2% | 13 | +1 | $1,508 | $304,328 | 6 | Golem Distribución | false | false |
| 41 | 25 | The Spiderwick Chronicles | $18,945 | -57.8% | 54 | -27 | $350 | $5,587,480 | 10 | Universal Pictures International (UPI) | false | false |
| 42 | 29 | Rendition | $18,805 | -46.6% | 21 | -20 | $895 | $1,293,917 | 5 | TriPictures | false | false |
| 43 | 41 | The Contract | $17,294 | +36.6% | 22 | +6 | $786 | $1,317,660 | 7 | Filmax | false | false |
| 44 | 36 | The Water Horse | $15,451 | -29.7% | 39 | -19 | $396 | $3,358,699 | 11 | Sony Pictures Releasing | false | false |
| 45 | 37 | The Kite Runner | $13,775 | -32.5% | 9 | -2 | $1,530 | $1,773,243 | 11 | Universal Pictures International (UPI) | false | false |
| 46 | - | Broken Sky | $9,416 | - | 2 | - | $4,708 | $10,897 | 1 | Karma Films | true | false |
| 47 | 49 | Enloquecidas | $7,332 | +19.5% | 2 | - | $3,666 | $151,625 | 6 | Premium Film | false | false |
| 48 | 42 | The Aerial | $7,225 | -36.7% | 3 | -1 | $2,408 | $26,297 | 2 | Sherlock Films | false | false |
| 49 | 46 | Bab'Aziz: The Prince That Contemplated His Soul | $7,155 | +6.5% | 5 | - | $1,431 | $201,408 | 11 | Karma Films | false | false |
| 50 | 44 | Cashback | $6,786 | -39.4% | 15 | +3 | $452 | $171,028 | 6 | - | false | false |
| 51 | 43 | The Pope's Toilet | $5,291 | -53.3% | 8 | -3 | $661 | $75,447 | 4 | Golem Distribución | false | false |
| 52 | 39 | Death Defying Acts | $5,261 | -59.7% | 13 | -9 | $404 | $2,850,127 | 7 | DeAPlaneta | false | false |
| 53 | 47 | Caramel | $5,133 | -19.9% | 4 | - | $1,283 | $1,805,509 | 18 | Alta Films | false | false |
| 54 | 48 | Franklin and the Turtle Lake Treasure | $3,869 | -37.4% | 14 | -2 | $276 | $717,467 | 13 | Wanda Visión S.A. | false | false |
| 55 | 40 | Before the Fall | $3,623 | -72.2% | 1 | -43 | $3,623 | $307,209 | 4 | Universal Pictures International (UPI) | false | false |
| 56 | 56 | 4 Months, 3 Weeks and 2 Days | $3,285 | +32% | 3 | +1 | $1,095 | $1,063,330 | 17 | Golem Distribución | false | false |
| 57 | 52 | Shine a Light | $3,276 | -40.5% | 7 | - | $468 | $275,550 | 7 | Vértigo Films | false | false |
| 58 | 54 | There Will Be Blood | $2,983 | -19.9% | 2 | - | $1,491 | $2,415,805 | 14 | Walt Disney Pictures | false | false |
| 59 | 57 | Dan in Real Life | $2,552 | +15.7% | 1 | -2 | $2,552 | $2,684,595 | 9 | Universal Pictures International (UPI) | false | false |
| 60 | 51 | Meet the Spartans | $1,725 | -68.8% | 10 | -7 | $172 | $6,472,199 | 8 | 20th Century Fox International | false | false |
| 61 | 60 | Buddha Collapsed Out of Shame | $1,659 | -13.8% | 5 | - | $331 | $465,394 | 12 | Wanda Visión S.A. | false | false |
| 62 | 59 | Closing the Ring | $1,608 | -23.2% | 1 | - | $1,608 | $260,490 | 10 | Manga Entertainment | false | false |
| 63 | 69 | Lo mejor de mí | $1,362 | +162.9% | 2 | +1 | $681 | $400,836 | 11 | Alta Films | false | false |
| 64 | 71 | One Missed Call | $1,004 | +150.4% | 4 | -1 | $251 | $2,114,412 | 9 | Warner Bros. | false | false |
| 65 | 58 | Reencarnación | $936 | -55.3% | 1 | - | $936 | $9,147 | 3 | N/A | false | false |
| 66 | 63 | The Silence Before Bach | $884 | -19.2% | 1 | -1 | $884 | $320,426 | 22 | Sherlock Films | false | false |
| 67 | 64 | Into the Wild | $475 | -54.5% | 1 | -2 | $475 | $769,860 | 17 | Universal Pictures International (UPI) | false | false |
| 68 | 55 | Asterix at the Olympic Games | $404 | -84.5% | 4 | -2 | $101 | $9,007,482 | 15 | TriPictures | false | false |
| 69 | 66 | It's a Free World... | $401 | -50.4% | 1 | - | $401 | $563,755 | 13 | Alta Films | false | false |
| 70 | 65 | 10,000 BC | $299 | -71.2% | 4 | -1 | $74 | $12,874,037 | 11 | Warner Bros. | false | false |
| 71 | 62 | Mirror Maze | $201 | -84% | 2 | -7 | $100 | $83,943 | 4 | Walt Disney Pictures | false | false |
| 72 | 74 | La Osa Mayor menos dos | $138 | -55.9% | 2 | +1 | $69 | $769 | 2 | Sagrera TV | false | false |
| 73 | 73 | Vantage Point | $110 | -68.6% | 2 | -1 | $55 | $6,721,872 | 12 | Sony Pictures Releasing | false | false |
| 74 | 80 | 30 Days of Night | $46 | -13.2% | 1 | - | $46 | $4,113,846 | 15 | Sony Pictures Releasing | false | false |
