| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Speed Racer | $403,010 | -31.1% | 85 | -1 | $4,741 | $1,120,851 | 2 | Warner Bros. | false | false |
| 2 | 2 | Iron Man | $188,806 | -32.2% | 75 | -3 | $2,517 | $1,238,068 | 3 | United International Pictures | false | false |
| 3 | - | What Happens in Vegas | $155,938 | - | 30 | - | $5,197 | $155,938 | 1 | 20th Century Fox International | true | false |
| 4 | 5 | Death at a Funeral | $111,860 | -1.9% | 33 | - | $3,389 | $1,515,027 | 11 | Compañía General de la Imagen (CGI) | false | false |
| 5 | 4 | The Oxford Murders | $97,572 | -15.2% | 23 | +1 | $4,242 | $243,887 | 2 | Pachamama Cine | false | false |
| 6 | 3 | The Nest | $95,477 | -20.4% | 38 | - | $2,512 | $775,339 | 4 | Distribution Company | false | false |
| 7 | - | The Counterfeiters | $81,283 | - | 13 | - | $6,252 | $81,283 | 1 | Alfa Films | true | false |
| 8 | - | Awake | $79,025 | - | 31 | - | $2,549 | $79,025 | 1 | Distribution Company | true | false |
| 9 | 6 | 21 | $52,010 | -33% | 36 | -1 | $1,444 | $618,223 | 5 | Sony Pictures Releasing | false | false |
| 10 | 8 | Shutter | $43,374 | -8.6% | 27 | -6 | $1,606 | $361,464 | 5 | 20th Century Fox International | false | false |
| 11 | 7 | Lamb of God | $31,837 | -36.8% | 13 | - | $2,449 | $93,732 | 2 | Alfa Films | false | false |
| 12 | 12 | Street Kings | $26,929 | +59.6% | 30 | -7 | $897 | $197,839 | 4 | 20th Century Fox International | false | false |
| 13 | 9 | Untraceable | $18,083 | -45.9% | 29 | - | $623 | $175,944 | 4 | Sony Pictures Releasing | false | false |
| 14 | - | Mrs Palfrey at the Claremont 2008 Re-release | $16,611 | - | 3 | - | $5,537 | $16,611 | 1 | Primer Plano Film Group | true | false |
| 15 | - | Yo soy sola | $15,220 | - | 10 | - | $1,522 | $15,220 | 1 | Alfa Films | true | false |
| 16 | 10 | Conversations with My Gardener | $14,451 | -38.7% | 9 | -4 | $1,605 | $144,101 | 4 | Alfa Films | false | false |
| 17 | 27 | Two Days in Paris | $9,492 | +133.8% | 9 | +4 | $1,054 | $338,933 | 8 | Impacto Cine | false | false |
| 18 | 11 | The Savages | $9,295 | -59.9% | 10 | -6 | $929 | $96,029 | 3 | 20th Century Fox International | false | false |
| 19 | 13 | The Orphanage | $9,190 | -40.6% | 17 | -16 | $540 | $712,910 | 10 | CDI Films | false | false |
| 20 | 15 | Horton Hears a Who! | $9,048 | -32.9% | 25 | -28 | $361 | $1,181,512 | 10 | 20th Century Fox International | false | false |
| 21 | 14 | In the Valley of Elah | $8,340 | -43.7% | 13 | - | $641 | $277,660 | 7 | Alfa Films | false | false |
| 22 | 17 | We Own the Night | $7,159 | -38.8% | 7 | -7 | $1,022 | $65,874 | 3 | CDI Films | false | false |
| 23 | 22 | Lust, Caution | $5,056 | -30.7% | 11 | -7 | $459 | $53,260 | 3 | Distribution Company | false | false |
| 24 | 19 | P.S. I Love You | $5,049 | -46.5% | 11 | -4 | $459 | $436,101 | 12 | Alfa Films | false | false |
| 25 | 21 | Jumper | $5,047 | -34.9% | 26 | -36 | $194 | $567,486 | 7 | 20th Century Fox International | false | false |
| 26 | - | El desierto negro | $4,893 | - | 2 | - | $2,446 | $4,893 | 1 | N/A | true | false |
| 27 | 25 | Persepolis | $4,025 | -38.9% | 4 | +1 | $1,006 | $36,331 | 4 | Sony Pictures Releasing | false | false |
| 28 | 35 | Elizabeth: The Golden Age | $3,783 | +197.6% | 4 | +2 | $945 | $105,035 | 10 | United International Pictures | false | false |
| 29 | 18 | Evening | $3,526 | -65.2% | 11 | -4 | $320 | $176,665 | 6 | Impacto Cine | false | false |
| 30 | 16 | 10,000 BC | $2,992 | -75.4% | 16 | -25 | $187 | $2,184,595 | 11 | Warner Bros. | false | false |
| 31 | 20 | The Game Plan | $2,735 | -66.1% | 23 | -28 | $118 | $1,445,460 | 14 | Walt Disney Pictures | false | false |
| 32 | 23 | The Spiderwick Chronicles | $2,729 | -62.3% | 19 | -12 | $143 | $656,376 | 9 | United International Pictures | false | false |
| 33 | 33 | Mr. Woodcock | $2,612 | +58.1% | 7 | +2 | $373 | $98,498 | 7 | Distribution Company | false | false |
| 34 | 29 | The Hunting Party | $2,422 | -9.4% | 10 | -1 | $242 | $304,818 | 9 | Distribution Company | false | false |
| 35 | - | S.O.S. Ex | $2,411 | - | 3 | - | $803 | $2,411 | 1 | N/A | true | false |
| 36 | 54 | Elite Squad | $2,324 | +868.3% | 8 | +1 | $290 | $106,643 | 7 | United International Pictures | false | false |
| 37 | 30 | Caramel | $2,034 | -22% | 6 | -1 | $339 | $211,014 | 8 | Alfa Films | false | false |
| 38 | 28 | No Country for Old Men | $1,904 | -52% | 18 | -2 | $105 | $954,585 | 11 | Walt Disney Pictures | false | false |
| 39 | 31 | The Bucket List | $1,552 | -37.4% | 6 | -6 | $258 | $1,934,403 | 15 | Warner Bros. | false | false |
| 40 | 36 | Diary of the Dead | $1,260 | +3.6% | 4 | -1 | $315 | $288,292 | 9 | Pachamama Cine | false | false |
| 41 | 42 | The Ugly Duckling and Me! | $1,240 | +86.7% | 10 | +1 | $124 | $73,806 | 9 | - | false | false |
| 42 | 26 | Twice Upon a Time | $1,203 | -80% | 3 | -6 | $401 | $106,009 | 5 | Pachamama Cine | false | false |
| 43 | 41 | Rancho aparte | $1,025 | +49.6% | 2 | - | $512 | $136,949 | 8 | Dream Company | false | false |
| 44 | 37 | The Eye | $904 | -7.5% | 4 | +2 | $226 | $229,640 | 12 | United International Pictures | false | false |
| 45 | 24 | Silk | $888 | -87.4% | 2 | -3 | $444 | $9,887 | 2 | Distribution Company | false | false |
| 46 | 44 | Shine a Light | $401 | -26.4% | 2 | -4 | $200 | $95,789 | 6 | Distribution Company | false | false |
| 47 | 49 | The Water Horse | $296 | +6.1% | 2 | -2 | $148 | $590,632 | 15 | Sony Pictures Releasing | false | false |
| 48 | 63 | The Golden Compass | $214 | +146% | 3 | +1 | $71 | $1,387,365 | 23 | Distribution Company | false | false |
| 49 | 52 | There Will Be Blood | $212 | -15.2% | 2 | -5 | $106 | $502,168 | 13 | Walt Disney Pictures | false | false |
| 50 | 60 | Alvin and the Chipmunks | $208 | +44.4% | 3 | - | $69 | $796,171 | 20 | 20th Century Fox International | false | false |
| 51 | - | Sweeney Todd: The Demon Barber of Fleet Street | $208 | - | 2 | - | $104 | $651,305 | 14 | Warner Bros. | false | false |
| 52 | 38 | King of California | $177 | -79.5% | 3 | -2 | $59 | $63,815 | 6 | Distribution Company | false | false |
| 53 | 56 | Juno | $168 | -18% | 2 | -1 | $84 | $462,394 | 14 | Alfa Films | false | false |
| 54 | 51 | Hannibal Rising | $166 | -35.2% | 1 | -1 | $166 | $89,287 | 13 | United International Pictures | false | false |
| 55 | 59 | Enchanted | $76 | -47.9% | 2 | -1 | $38 | $2,792,653 | 20 | Walt Disney Pictures | false | false |
| 56 | 32 | Rain | $70 | -95.9% | 4 | -12 | $17 | $158,593 | 9 | Walt Disney Pictures | false | false |
| 57 | 62 | D-Graduated | $64 | -31.9% | 1 | - | $64 | $15,004 | 8 | Distribution Company | false | false |
| 58 | 39 | La orilla que se abisma | $63 | -92.7% | 1 | -1 | $63 | $2,486 | 3 | Primer Plano Film Group | false | false |
| 59 | 47 | Winter Visitor | $60 | -80.8% | 1 | -4 | $60 | $34,155 | 7 | Primer Plano Film Group | false | false |
| 60 | 67 | National Treasure: Book of Secrets | $44 | +10% | 1 | -2 | $44 | $1,660,765 | 18 | Walt Disney Pictures | false | false |
| 61 | 70 | Bee Movie | $38 | +40.7% | 2 | +1 | $19 | $1,481,104 | 24 | United International Pictures | false | false |
| 62 | 43 | The Nanny Diaries | $33 | -94.3% | 1 | -3 | $33 | $70,321 | 5 | Alfa Films | false | false |
| 63 | 61 | Atonement | $32 | -68.3% | 1 | - | $32 | $503,379 | 15 | United International Pictures | false | false |
| 64 | 71 | Underdog | $23 | - | 1 | - | $23 | $848,825 | 33 | Walt Disney Pictures | false | false |
| 65 | 72 | Explosive Brigade: Pirate Mission | $22 | +57.1% | 2 | -1 | $11 | $763,987 | 16 | Argentina Sono Film S.A.C.I. | false | false |
