| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Iron Man | $5,788,340 | - | 365 | - | $15,858 | $5,788,340 | 1 | Paramount Pictures International | true | false |
| 2 | - | Made of Honor | $1,439,053 | - | 256 | - | $5,621 | $1,439,053 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | Forgetting Sarah Marshall | $658,792 | -57% | 248 | -7 | $2,656 | $5,041,178 | 3 | Universal Pictures International (UPI) | false | false |
| 4 | 7 | The Painted Veil | $317,936 | -35.8% | 49 | - | $6,488 | $1,124,994 | 2 | Paramount Pictures International | false | false |
| 5 | 2 | Street Kings | $294,366 | -67.2% | 216 | -6 | $1,362 | $3,373,581 | 3 | 20th Century Fox International | false | false |
| 6 | 5 | Deception | $249,239 | -56.7% | 112 | +1 | $2,225 | $1,010,811 | 2 | 20th Century Fox International | false | false |
| 7 | 4 | Nim's Island | $178,203 | -76.4% | 185 | -11 | $963 | $5,241,867 | 5 | Universal Pictures International (UPI) | false | false |
| 8 | 8 | Untraceable | $165,610 | -65.5% | 122 | - | $1,357 | $789,319 | 2 | Universal Pictures International (UPI) | false | false |
| 9 | 12 | Gone Baby Gone | $140,772 | -45.4% | 40 | +1 | $3,519 | $832,078 | 3 | Walt Disney Pictures | false | false |
| 10 | 3 | The Spiderwick Chronicles | $129,249 | -83.1% | 200 | -50 | $646 | $7,180,052 | 5 | Paramount Pictures International | false | false |
| 11 | 10 | Smart People | $113,059 | -67.9% | 132 | - | $856 | $578,664 | 2 | Icon Film Distribution | false | false |
| 12 | 16 | Lars and the Real Girl | $92,262 | -39.7% | 34 | - | $2,713 | $865,375 | 5 | Rialto Distribution | false | false |
| 13 | 11 | Prom Night | $91,653 | -72.1% | 83 | -41 | $1,104 | $2,469,835 | 4 | Sony Pictures Releasing | false | false |
| 14 | 9 | Superhero Movie | $88,117 | -81.3% | 129 | -57 | $683 | $3,135,246 | 4 | Roadshow Films | false | false |
| 15 | 15 | U2 3D | $85,604 | -50.1% | 17 | -6 | $5,035 | $1,003,417 | 4 | Roadshow Films | false | false |
| 16 | 6 | Horton Hears a Who! | $83,625 | -84.8% | 184 | -103 | $454 | $10,319,874 | 7 | 20th Century Fox International | false | false |
| 17 | 24 | The Edge of Heaven | $78,934 | +4.9% | 13 | +1 | $6,071 | $247,228 | 2 | Sharmill Films | false | false |
| 18 | - | Miss Pettigrew Lives for a Day | $74,297 | - | 71 | - | $1,046 | $74,297 | - | Roadshow Films | - | false |
| 19 | 18 | Paris | $50,325 | -51.9% | 30 | - | $1,677 | $588,445 | 4 | Icon Film Distribution | false | false |
| 20 | 21 | The Black Balloon | $45,278 | -47.9% | 53 | -17 | $854 | $1,932,967 | 9 | Icon Film Distribution | false | false |
| 21 | 13 | Step Up 2: The Streets | $44,446 | -81.8% | 72 | -90 | $617 | $8,396,485 | 7 | Universal Pictures International (UPI) | false | false |
| 22 | - | Cactus | $42,714 | - | 40 | - | $1,067 | $78,941 | 1 | Hoyts Distribution | true | false |
| 23 | 20 | Before the Devil Knows You're Dead | $41,778 | -55.7% | 36 | -10 | $1,160 | $1,326,990 | 7 | Hopscotch Films | false | false |
| 24 | - | Molière | $38,176 | - | 35 | - | $1,090 | $38,176 | 1 | Hopscotch Films | true | false |
| 25 | 14 | Semi-Pro | $35,905 | -85.3% | 71 | -75 | $505 | $3,773,630 | 5 | Roadshow Films | false | false |
| 26 | 19 | The Other Boleyn Girl | $32,436 | -66.2% | 63 | -21 | $514 | $3,762,217 | 8 | Universal Pictures International (UPI) | false | false |
| 27 | 23 | Never Back Down | $12,669 | -83.3% | 52 | -7 | $243 | $2,954,256 | 6 | Roadshow Films | false | false |
| 28 | 27 | The Bucket List | $11,089 | -73.9% | 11 | -36 | $1,008 | $7,323,266 | 11 | Warner Bros. | false | false |
| 29 | 22 | St. Trinian's | $9,996 | -88% | 23 | -57 | $434 | $2,500,112 | 6 | Sony Pictures Releasing | false | false |
| 30 | 30 | Be Kind Rewind | $9,494 | -67.9% | 7 | -11 | $1,356 | $872,222 | 7 | Roadshow Films | false | false |
| 31 | 28 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $6,862 | -80% | 10 | -5 | $686 | $1,204,893 | 7 | Walt Disney Pictures | false | false |
| 32 | 33 | Brick Lane | $6,721 | -69.5% | 15 | -3 | $448 | $570,020 | 7 | Madman Entertainment | false | false |
| 33 | 37 | Closing the Ring | $5,867 | -55.5% | 22 | +2 | $266 | $343,585 | 9 | Hopscotch Films | false | false |
| 34 | - | Silk | $4,820 | - | 41 | - | $117 | $4,820 | 1 | Roadshow Films | true | false |
| 35 | 38 | In the Valley of Elah | $4,554 | -64.3% | 12 | -7 | $379 | $548,769 | 10 | Hoyts Distribution | false | false |
| 36 | 56 | Two Days in Paris | $3,496 | +314.2% | 2 | -1 | $1,748 | $1,701,189 | 19 | Hopscotch Films | false | false |
| 37 | 48 | Run Fatboy Run | $2,710 | -15.2% | 9 | -12 | $301 | $3,119,274 | 9 | Roadshow Films | false | false |
| 38 | 47 | In the Shadow of the Moon | $2,237 | -48.6% | 6 | +1 | $372 | $355,682 | 9 | Madman Entertainment | false | false |
| 39 | 44 | Juno | $2,006 | -71.4% | 8 | -5 | $250 | $10,951,850 | 16 | Walt Disney Studios Motion Pictures | false | false |
| 40 | - | Am Limit | $1,709 | - | 1 | - | $1,709 | $1,709 | 1 | N/A | true | false |
| 41 | 40 | 10,000 BC | $1,394 | -88.9% | 9 | -4 | $154 | $6,111,031 | 9 | Warner Bros. | false | false |
| 42 | 50 | Bella | $903 | -55.1% | 3 | -2 | $301 | $199,690 | 11 | Hopscotch Films | false | false |
| 43 | 55 | Paranoid Park | $333 | -73.1% | 2 | +1 | $166 | $59,367 | 9 | Madman Entertainment | false | false |
| 44 | - | Grindhouse | $314 | - | 1 | - | $314 | $109,275 | 21 | Roadshow Films | false | false |
