| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Meet the Spartans | $1,743,066 | - | 286 | - | $6,094 | $2,023,728 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Step Up 2: The Streets | $1,398,165 | -37.7% | 333 | +25 | $4,198 | $4,438,480 | 2 | Moviemax | false | false |
| 3 | 3 | 21 | $891,954 | -21.8% | 246 | -1 | $3,625 | $2,525,713 | 2 | Sony Pictures Releasing | false | false |
| 4 | 2 | Horton Hears a Who! | $814,893 | -41.8% | 423 | -40 | $1,926 | $2,608,798 | 2 | 20th Century Fox International | false | false |
| 5 | - | The Other Boleyn Girl | $560,418 | - | 102 | - | $5,494 | $629,075 | 1 | Universal Pictures International (UPI) | true | false |
| 6 | - | Fool's Gold | $516,263 | - | 232 | - | $2,225 | $622,666 | 1 | Warner Bros. | true | false |
| 7 | - | Evening | $496,375 | - | 180 | - | $2,757 | $547,473 | 1 | Medusa Distribuzione | true | false |
| 8 | 4 | The Kite Runner | $492,590 | -45% | 227 | -106 | $2,170 | $11,866,363 | 5 | Filmauro | false | false |
| 9 | 5 | Nim's Island | $462,280 | -45.1% | 203 | -69 | $2,277 | $3,662,713 | 3 | Moviemax | false | false |
| 10 | - | The Demons of St. Petersburg | $449,981 | - | 110 | - | $4,090 | $496,161 | 1 | 01 Distribution | true | false |
| 11 | 6 | Leatherheads | $446,001 | -43% | 192 | -21 | $2,322 | $3,065,782 | 3 | Universal Pictures International (UPI) | false | false |
| 12 | 7 | La seconda volta non si scorda mai | $301,382 | -41.2% | 58 | -78 | $5,196 | $2,398,110 | 3 | Mikado Film | false | false |
| 13 | - | Over Her Dead Body | $274,793 | - | 133 | - | $2,066 | $304,384 | 1 | Eagle Pictures | true | false |
| 14 | 8 | Next | $238,990 | -48.8% | 90 | -65 | $2,655 | $4,421,481 | 4 | Medusa Distribuzione | false | false |
| 15 | - | The Girl by the Lake | $226,742 | - | 95 | - | $2,386 | $4,251,714 | 33 | Medusa Distribuzione | false | false |
| 16 | 10 | Tutta la vita davanti | $201,599 | -39.7% | 60 | -44 | $3,359 | $5,540,886 | 5 | Medusa Distribuzione | false | false |
| 17 | 9 | The Last Deadly Mission | $182,680 | -54.3% | 83 | -78 | $2,200 | $732,933 | 2 | Medusa Distribuzione | false | false |
| 18 | 11 | Juno | $150,315 | -48.7% | 86 | -79 | $1,747 | $2,697,898 | 4 | 20th Century Fox International | false | false |
| 19 | 13 | Non pensarci | $136,592 | -26.6% | 40 | -19 | $3,414 | $1,700,261 | 4 | 01 Distribution | false | false |
| 20 | 12 | Love Is Not Enough | $111,306 | -41.7% | 61 | -15 | $1,824 | $379,220 | 2 | Mediafilm | false | false |
| 21 | - | L'anno mille | $100,052 | - | 38 | - | $2,632 | $118,842 | 1 | Mediafilm | true | false |
| 22 | 15 | Introducing the Dwights | $71,324 | -53.3% | 52 | -17 | $1,371 | $285,092 | 2 | Lucky Red | false | false |
| 23 | 17 | Shine a Light | $64,150 | -51.5% | 57 | +10 | $1,125 | $381,697 | 3 | BIM Distribuzione | false | false |
| 24 | 14 | The Oxford Murders | $61,181 | -66.2% | 32 | -63 | $1,911 | $783,337 | 3 | Warner Bros. | false | false |
| 25 | - | U2 3D | $56,190 | - | 11 | - | $5,108 | $73,627 | 1 | Independent Films | true | false |
| 26 | 24 | Before the Devil Knows You're Dead | $53,851 | +99% | 19 | +9 | $2,834 | $4,212,760 | 7 | Medusa Distribuzione | false | false |
| 27 | 18 | 10 Items or Less | $50,519 | -49.1% | 29 | -6 | $1,742 | $182,224 | 2 | DNC Entertainment | false | false |
| 28 | 19 | Ci sta un francese, un inglese e un napoletano | $47,277 | -9.6% | 17 | +3 | $2,781 | $801,025 | 5 | Medusa Distribuzione | false | false |
| 29 | 26 | La velocità della luce | $42,958 | +153.1% | 9 | +6 | $4,773 | $72,817 | 2 | Mediaplex | false | false |
| 30 | 23 | The Band's Visit | $27,336 | -3.1% | 13 | - | $2,102 | $820,820 | 6 | Mikado Film | false | false |
| 31 | 16 | Amore, bugie & calcetto | $24,409 | -82% | 17 | -68 | $1,435 | $2,156,003 | 4 | Warner Bros. | false | false |
| 32 | 21 | Good Morning Heartache | $22,625 | -41.8% | 13 | -17 | $1,740 | $241,109 | 3 | Medusa Distribuzione | false | false |
| 33 | 22 | The Zone | $19,217 | -38.8% | 7 | -5 | $2,745 | $222,926 | 4 | Sacher Distribuzione | false | false |
| 34 | 25 | The Fox and the Child | $11,879 | -54.4% | 22 | -24 | $539 | $2,260,704 | 6 | Lucky Red | false | false |
| 35 | 35 | Persepolis | $11,538 | +58.1% | 6 | +1 | $1,923 | $1,783,277 | 10 | BIM Distribuzione | false | false |
| 36 | 29 | My Blueberry Nights | $8,473 | -23.1% | 8 | +1 | $1,059 | $643,745 | 5 | BIM Distribuzione | false | false |
| 37 | 31 | The Wind Blows Round | $8,417 | -15.6% | 3 | -3 | $2,805 | $586,922 | 52 | Aranciafilm | false | false |
| 38 | 28 | No Country for Old Men | $8,041 | -27.8% | 6 | +1 | $1,340 | $8,934,145 | 10 | Universal Pictures International (UPI) | false | false |
| 39 | 39 | Cover Boy... Last Revolution | $7,277 | +46.1% | 5 | +1 | $1,455 | $126,514 | 6 | Istituto Luce | false | false |
| 40 | 32 | Into the Wild | $5,903 | -34.5% | 4 | - | $1,475 | $7,890,770 | 14 | BIM Distribuzione | false | false |
| 41 | 34 | Jimmy della collina | $5,452 | -25.3% | 5 | +1 | $1,090 | $47,373 | 4 | Aranciafilm | false | false |
| 42 | 30 | The Spiderwick Chronicles | $4,544 | -56.5% | 9 | -21 | $504 | $3,399,636 | 6 | Universal Pictures International (UPI) | false | false |
| 43 | 27 | Interview | $4,367 | -68.1% | 5 | -11 | $873 | $113,717 | 3 | Fandango | false | false |
| 44 | 45 | The Early Bird Catches the Worm | $3,163 | +0.9% | 1 | -2 | $3,163 | $1,437,209 | 9 | Medusa Distribuzione | false | false |
| 45 | 38 | Gone Baby Gone | $2,436 | -57.2% | 2 | -2 | $1,218 | $97,752 | 4 | Walt Disney Pictures | false | false |
| 46 | - | 10,000 BC | $2,253 | - | 3 | - | $751 | $8,188,578 | 7 | Warner Bros. | false | false |
| 47 | 33 | Quiet Chaos | $2,209 | -70.1% | 1 | -6 | $2,209 | $8,380,199 | 12 | 01 Distribution | false | false |
| 48 | 41 | Colpo d'occhio | $2,138 | -56.1% | 3 | -5 | $712 | $4,057,969 | 6 | 01 Distribution | false | false |
| 49 | - | Fallen Heroes | $1,525 | - | 2 | - | $762 | $81,917 | 5 | BIM Distribuzione | false | false |
| 50 | 42 | Odette Toulemonde | $1,498 | -61.5% | 3 | -1 | $499 | $409,506 | 8 | Warner Bros. | false | false |
| 51 | 36 | The Water Horse | $1,173 | -80% | 5 | -21 | $234 | $1,944,480 | 7 | Sony Pictures Releasing | false | false |
