| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | 21 | $3,247,746 | - | 354 | - | $9,174 | $3,247,746 | 1 | Sony Pictures Releasing | true | false |
| 2 | 2 | Son of Rambow | $1,475,904 | -17.4% | 308 | - | $4,791 | $4,610,407 | 2 | Optimum Releasing | false | false |
| 3 | 1 | 27 Dresses | $1,355,628 | -33.9% | 432 | -2 | $3,138 | $10,700,738 | 3 | 20th Century Fox International | false | false |
| 4 | 5 | The Spiderwick Chronicles | $1,332,280 | -19.1% | 496 | +11 | $2,686 | $17,436,622 | 4 | Paramount Pictures International | false | false |
| 5 | 3 | Step Up 2: The Streets | $1,303,504 | -26.1% | 377 | +13 | $3,457 | $17,360,339 | 4 | Universal Pictures International (UPI) | false | false |
| 6 | - | Leatherheads | $934,606 | - | 335 | - | $2,789 | $934,606 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 6 | Horton Hears a Who! | $849,833 | -24% | 483 | -26 | $1,759 | $14,779,187 | 4 | 20th Century Fox International | false | false |
| 8 | 4 | Never Back Down | $822,687 | -51.2% | 326 | - | $2,523 | $3,313,900 | 2 | Momentum Pictures | false | false |
| 9 | - | Shine a Light | $665,474 | - | 150 | - | $4,436 | $665,474 | 1 | 20th Century Fox International | true | false |
| 10 | - | Pathology | $617,886 | - | 258 | - | $2,394 | $617,886 | 1 | Entertainment Film Distributors | true | false |
| 11 | 7 | Awake | $583,264 | -46.5% | 280 | -1 | $2,083 | $2,325,598 | 2 | Icon Film Distribution | false | false |
| 12 | 8 | One Missed Call | $445,437 | -48.3% | 252 | -2 | $1,767 | $1,820,226 | 2 | Warner Bros. | false | false |
| 13 | 9 | Drillbit Taylor | $343,947 | -57.7% | 285 | -18 | $1,206 | $3,987,667 | 3 | Paramount Pictures International | false | false |
| 14 | - | U Me Aur Hum | $338,281 | - | 46 | - | $7,353 | $338,281 | 1 | Eros Worldwide | true | false |
| 15 | 11 | The Orphanage | $211,969 | -41.2% | 87 | -27 | $2,436 | $2,914,423 | 4 | Optimum Releasing | false | false |
| 16 | - | REC | $182,175 | - | 70 | - | $2,602 | $182,175 | 1 | - | true | false |
| 17 | 15 | In Bruges | $171,219 | -30.9% | 50 | -10 | $3,424 | $4,190,102 | 6 | Universal Pictures International (UPI) | false | false |
| 18 | 14 | The Game Plan | $167,374 | -41.5% | 241 | -78 | $694 | $7,977,047 | 6 | Walt Disney Pictures | false | false |
| 19 | - | Krazzy 4 | $127,384 | - | 21 | - | $6,065 | $127,384 | 1 | Eros Worldwide | true | false |
| 20 | 18 | My Brother is an Only Child | $121,252 | -24.6% | 23 | -2 | $5,271 | $381,407 | 2 | Revolver Entertainment | false | false |
| 21 | 51 | Underdog | $114,807 | +3,368.5% | 55 | +47 | $2,087 | $2,444,543 | 11 | Walt Disney Pictures | false | false |
| 22 | 10 | Vantage Point | $111,850 | -70.9% | 103 | -134 | $1,085 | $11,432,770 | 6 | Sony Pictures Releasing | false | false |
| 23 | 13 | 10,000 BC | $100,366 | -70.7% | 141 | -149 | $711 | $11,200,988 | 5 | Warner Bros. | false | false |
| 24 | 16 | The Other Boleyn Girl | $79,541 | -57.6% | 52 | -74 | $1,529 | $8,961,098 | 6 | Universal Pictures International (UPI) | false | false |
| 25 | 12 | Meet the Spartans | $75,390 | -78.5% | 125 | -182 | $603 | $6,269,154 | 4 | 20th Century Fox International | false | false |
| 26 | 20 | There Will Be Blood | $74,661 | -45.6% | 61 | -23 | $1,223 | $9,093,093 | 10 | Walt Disney Pictures | false | false |
| 27 | 17 | Funny Games | $52,980 | -69.9% | 46 | -17 | $1,151 | $331,480 | 2 | Tartan | false | false |
| 28 | 19 | How She Move | $50,020 | -68.1% | 52 | -16 | $961 | $309,500 | 2 | Paramount Pictures International | false | false |
| 29 | 21 | The Bank Job | $48,199 | -64.7% | 40 | -40 | $1,204 | $7,923,091 | 7 | Lionsgate | false | false |
| 30 | 24 | Lars and the Real Girl | $43,409 | -37.6% | 22 | -3 | $1,973 | $667,354 | 4 | Verve Pictures | false | false |
| 31 | 23 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $42,752 | -44.8% | 43 | -18 | $994 | $1,485,000 | 5 | Walt Disney Pictures | false | false |
| 32 | 25 | Alvin and the Chipmunks | $40,467 | -33.5% | 87 | -43 | $465 | $23,052,742 | 17 | 20th Century Fox International | false | false |
| 33 | 36 | The Diving Bell and the Butterfly | $38,990 | +54.6% | 24 | +9 | $1,624 | $1,547,957 | 10 | Pathé | false | false |
| 34 | 27 | Love in the Time of Cholera | $29,955 | -41.6% | 25 | -5 | $1,198 | $608,313 | 4 | Momentum Pictures | false | false |
| 35 | 22 | Race | $29,207 | -73.6% | 24 | -18 | $1,216 | $1,692,902 | 4 | UTV Motion Pictures | false | false |
| 36 | - | Strange Wilderness | $26,299 | - | 53 | - | $496 | $26,299 | 1 | Paramount Pictures International | true | false |
| 37 | 35 | You, the Living | $25,220 | -7.6% | 7 | - | $3,602 | $135,494 | 3 | Artificial Eye | false | false |
| 38 | 28 | No Country for Old Men | $24,439 | -45.5% | 15 | -6 | $1,629 | $14,016,181 | 13 | Paramount Pictures International | false | false |
| 39 | 33 | Grindhouse | $22,561 | -23.5% | 34 | -9 | $663 | $122,425 | 3 | Momentum Pictures | false | false |
| 40 | - | Santhosh Subramaniyam | $19,817 | - | 4 | - | $4,954 | $19,817 | 1 | Ayngaran International | true | false |
| 41 | 38 | The Ugly Duckling and Me! | $19,705 | +54.6% | 61 | -14 | $323 | $766,152 | 41 | Eclipse Pictures | false | false |
| 42 | 32 | Juno | $19,593 | -34.7% | 14 | -16 | $1,399 | $19,105,809 | 10 | 20th Century Fox International | false | false |
| 43 | - | The Last Mistress | $19,463 | - | 2 | - | $9,731 | $19,463 | 1 | Artificial Eye | true | false |
| 44 | 37 | The Golden Compass | $15,169 | +8.4% | 66 | -4 | $229 | $51,533,744 | 19 | Entertainment Film Distributors | false | false |
| 45 | - | The 39 Steps 2008 Re-release | $13,970 | - | 3 | - | $4,656 | $13,970 | 1 | Park Circus | true | false |
| 46 | 34 | The Water Horse | $13,356 | -52.4% | 36 | -51 | $371 | $9,373,644 | 10 | Sony Pictures Releasing | false | false |
| 47 | 68 | The Conformist 2008 Re-release | $10,301 | +2,443.5% | 6 | +5 | $1,716 | $187,530 | 7 | British Film Institute (BFI) | false | false |
| 48 | 26 | One Two Three | $9,717 | -81.4% | 6 | -9 | $1,619 | $229,209 | 3 | Eros Worldwide | false | false |
| 49 | 44 | The Kite Runner | $8,156 | +11.5% | 4 | -1 | $2,039 | $7,141,352 | 16 | Paramount Pictures International | false | false |
| 50 | - | Yaaradi Nee Mohini | $6,636 | - | 3 | - | $2,212 | $42,837 | 2 | Ayngaran International | false | false |
| 51 | 31 | Welcome to the Sticks | $6,268 | -79.4% | 1 | - | $6,268 | $50,864 | 2 | Pathé | false | false |
| 52 | 29 | Penelope | $5,128 | -87.7% | 18 | -91 | $284 | $6,410,709 | 11 | Momentum Pictures | false | false |
| 53 | 45 | Water Lilies | $4,577 | -11.1% | 2 | - | $2,288 | $91,961 | 5 | Slingshot Studios | false | false |
| 54 | 39 | Be Kind Rewind | $3,955 | -65% | 5 | -11 | $791 | $7,570,429 | 8 | Pathé | false | false |
| 55 | 30 | U2 3D | $3,852 | -87.4% | 2 | -5 | $1,926 | $1,347,833 | 8 | Revolver Entertainment | false | false |
| 56 | 42 | The Accidental Husband | $3,520 | -53.5% | 8 | -11 | $440 | $4,950,356 | 7 | Momentum Pictures | false | false |
| 57 | 41 | Untraceable | $3,378 | -65.3% | 4 | -9 | $844 | $3,440,049 | 7 | Universal Pictures International (UPI) | false | false |
| 58 | 53 | Sweeney Todd: The Demon Barber of Fleet Street | $3,278 | +25.5% | 3 | +1 | $1,092 | $21,551,067 | 12 | Warner Bros. | false | false |
| 59 | 63 | I'm a Cyborg, But That's OK | $3,014 | +271.6% | 3 | +2 | $1,004 | $9,691 | 2 | Tartan | false | false |
| 60 | 62 | Away from Her | $2,848 | +207.9% | 4 | +1 | $712 | $296,079 | 9 | Metrodome Distribution | false | false |
| 61 | - | Lonesome Jim 2008 Re-release | $2,732 | - | 1 | - | $2,732 | $2,732 | 1 | Lionsgate | true | false |
| 62 | - | The Banquet | $2,031 | - | 1 | - | $2,031 | $2,031 | 1 | - | true | false |
| 63 | 61 | My Blueberry Nights | $1,919 | +104.4% | 3 | +1 | $639 | $542,691 | 8 | Optimum Releasing | false | false |
| 64 | 67 | We Are Together | $1,799 | +284.4% | 2 | +1 | $899 | $46,524 | 6 | Shooting People | false | false |
| 65 | 57 | Children of Glory | $1,677 | -25.6% | 3 | - | $559 | $28,427 | 5 | Lionsgate | false | false |
| 66 | 48 | The Edge of Heaven | $1,528 | -66.9% | 1 | -3 | $1,528 | $273,941 | 8 | Artificial Eye | false | false |
| 67 | 60 | Under the Bombs | $1,291 | +5.1% | 2 | +1 | $645 | $27,185 | 4 | Artificial Eye | false | false |
| 68 | 49 | Diary of the Dead | $1,093 | -72.6% | 2 | -6 | $546 | $851,518 | 6 | Optimum Releasing | false | false |
| 69 | 52 | Redacted | $907 | -70.9% | 2 | -4 | $453 | $34,703 | 5 | Optimum Releasing | false | false |
| 70 | 54 | Beaufort | $852 | -66.5% | 1 | -1 | $852 | $22,514 | 3 | Trinity Filmed Entertainment | false | false |
| 71 | 56 | In the Valley of Elah | $638 | -72.9% | 2 | -1 | $319 | $1,704,906 | 12 | Optimum Releasing | false | false |
| 72 | 40 | First Sunday | $614 | -93.8% | 3 | -18 | $204 | $154,941 | 3 | Sony Pictures Releasing | false | false |
| 73 | - | Asterix at the Olympic Games | $492 | - | 2 | - | $246 | $41,217 | 11 | Pathé | false | false |
| 74 | - | The Devil Came on Horseback | $451 | - | 1 | - | $451 | $451 | 1 | Periscoop Film | true | false |
| 75 | 66 | Azur & Asmar: The Princes' Quest | $354 | -31.7% | 1 | -2 | $354 | $66,541 | 10 | Soda Pictures | false | false |
| 76 | 47 | La Vie En Rose | $346 | -92.9% | 1 | -3 | $346 | $3,335,037 | 43 | Icon Film Distribution | false | false |
| 77 | - | Still Life | $128 | - | 1 | - | $128 | $67,455 | 11 | British Film Institute (BFI) | false | false |
| 78 | 58 | Flight of the Red Balloon | $39 | -97.5% | 1 | - | $39 | $79,963 | 5 | Park Circus | false | false |
| 79 | 69 | 4 Months, 3 Weeks and 2 Days | $39 | -89.1% | 1 | -1 | $39 | $582,469 | 15 | Artificial Eye | false | false |
