| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Spiderwick Chronicles | $1,278,678 | - | 267 | - | $4,789 | $2,167,908 | 1 | Paramount Pictures International | true | false |
| 2 | - | Semi-Pro | $1,278,413 | - | 202 | - | $6,328 | $1,332,797 | 1 | Roadshow Films | true | false |
| 3 | 1 | Horton Hears a Who! | $947,651 | -35.2% | 357 | -6 | $2,654 | $6,651,117 | 3 | 20th Century Fox International | false | false |
| 4 | 2 | Step Up 2: The Streets | $809,497 | -38.2% | 188 | - | $4,305 | $6,280,087 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 3 | Never Back Down | $615,305 | -31.4% | 151 | - | $4,074 | $1,858,913 | 2 | Roadshow Films | false | false |
| 6 | - | Nim's Island | $565,915 | - | 95 | - | $5,957 | $565,915 | 1 | Universal Pictures International (UPI) | true | false |
| 7 | 5 | St. Trinian's | $497,727 | -25.4% | 209 | +1 | $2,381 | $1,454,665 | 2 | Sony Pictures Releasing | false | false |
| 8 | 4 | Drillbit Taylor | $385,144 | -45.8% | 194 | -1 | $1,985 | $3,175,777 | 3 | Paramount Pictures International | false | false |
| 9 | 7 | Vantage Point | $308,521 | -39.9% | 160 | -33 | $1,928 | $3,702,088 | 4 | Sony Pictures Releasing | false | false |
| 10 | 8 | The Other Boleyn Girl | $297,618 | -29.8% | 132 | - | $2,254 | $2,962,317 | 4 | Universal Pictures International (UPI) | false | false |
| 11 | 10 | The Bucket List | $179,844 | -34.2% | 128 | -45 | $1,405 | $6,794,176 | 7 | Warner Bros. | false | false |
| 12 | 9 | 10,000 BC | $171,105 | -52.6% | 140 | -59 | $1,222 | $5,821,963 | 5 | Warner Bros. | false | false |
| 13 | 11 | Before the Devil Knows You're Dead | $164,584 | -7.6% | 22 | +2 | $7,481 | $709,166 | 3 | Hopscotch Films | false | false |
| 14 | 14 | The Black Balloon | $138,974 | -6.2% | 76 | +8 | $1,828 | $1,308,381 | 5 | Icon Film Distribution | false | false |
| 15 | - | Lars and the Real Girl | $121,830 | - | 17 | - | $7,166 | $121,830 | 1 | Rialto Distribution | true | false |
| 16 | 13 | Be Kind Rewind | $97,612 | -35.3% | 41 | - | $2,380 | $629,378 | 3 | Roadshow Films | false | false |
| 17 | 12 | The Eye | $82,604 | -47% | 49 | -51 | $1,685 | $1,320,763 | 4 | Paramount Pictures International | false | false |
| 18 | 18 | Brick Lane | $75,023 | -14.8% | 21 | +2 | $3,572 | $345,560 | 3 | Madman Entertainment | false | false |
| 19 | 16 | Hey Hey It's Esther Blueburger | $62,196 | -56% | 134 | - | $464 | $703,737 | 3 | Walt Disney Pictures | false | false |
| 20 | 17 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $56,347 | -53.6% | 20 | +1 | $2,817 | $997,111 | 3 | Walt Disney Pictures | false | false |
| 21 | 19 | No Country for Old Men | $49,935 | -31.4% | 48 | -10 | $1,040 | $5,658,525 | 16 | Paramount Pictures International | false | false |
| 22 | 24 | The Kite Runner | $43,963 | +14.4% | 35 | +3 | $1,256 | $2,548,274 | 12 | Paramount Pictures International | false | false |
| 23 | 15 | Run Fatboy Run | $40,861 | -71.9% | 43 | -110 | $950 | $3,005,694 | 5 | Roadshow Films | false | false |
| 24 | - | African Adventure: Safari in the Okavango | $38,347 | - | 2 | - | $19,173 | $406,456 | 55 | IMAX | false | false |
| 25 | 22 | There Will Be Blood | $37,079 | -26.6% | 38 | -8 | $975 | $2,303,894 | 9 | Walt Disney Pictures | false | false |
| 26 | 20 | Juno | $30,081 | -47.1% | 65 | -2 | $462 | $10,721,973 | 12 | Walt Disney Studios Motion Pictures | false | false |
| 27 | 29 | The Diving Bell and the Butterfly | $24,669 | -13.2% | 27 | -5 | $913 | $918,164 | 8 | Icon Film Distribution | false | false |
| 28 | 26 | In the Shadow of the Moon | $21,604 | -35.9% | 18 | -1 | $1,200 | $315,416 | 5 | Madman Entertainment | false | false |
| 29 | - | Dolphins and Whales 3D: Tribes of the Ocean | $19,863 | - | 1 | - | $19,863 | $133,630 | 4 | IMAX | false | false |
| 30 | 23 | Race | $17,657 | -61.7% | 14 | - | $1,261 | $314,921 | 3 | MG Distribution | false | false |
| 31 | 27 | Jumper | $16,855 | -42.8% | 27 | +2 | $624 | $8,241,451 | 8 | 20th Century Fox International | false | false |
| 32 | 28 | L'invité | $16,099 | -43.9% | 15 | - | $1,073 | $225,629 | 3 | Dendy Films | false | false |
| 33 | 34 | Deep Water | $12,066 | +7.4% | 1 | - | $12,066 | $229,740 | 26 | Hopscotch Films | false | false |
| 34 | 31 | Definitely, Maybe | $10,978 | -48.6% | 33 | - | $332 | $4,156,402 | 8 | Universal Pictures International (UPI) | false | false |
| 35 | 30 | One Two Three | $9,650 | -55.2% | 7 | - | $1,378 | $38,339 | 2 | Eros Worldwide | false | false |
| 36 | - | Sea Monsters: A Prehistoric Adventure | $9,618 | - | 2 | - | $4,809 | $1,219,533 | 29 | IMAX | false | false |
| 37 | 41 | Closing the Ring | $9,225 | +1.3% | 16 | +4 | $576 | $275,593 | 5 | Hopscotch Films | false | false |
| 38 | 32 | Sweeney Todd: The Demon Barber of Fleet Street | $9,086 | -52.6% | 20 | -10 | $454 | $5,047,935 | 11 | Warner Bros. | false | false |
| 39 | 36 | In the Valley of Elah | $7,539 | -32.5% | 11 | +1 | $685 | $459,133 | 6 | Hoyts Distribution | false | false |
| 40 | 39 | Meet the Spartans | $7,278 | -24.4% | 17 | - | $428 | $2,742,071 | 6 | 20th Century Fox International | false | false |
| 41 | - | Deep Sea | $6,889 | - | 2 | - | $3,444 | $4,504,109 | 110 | IMAX | false | false |
| 42 | - | Dinosaurs: Giants of Patagonia | $6,510 | - | 2 | - | $3,255 | $1,955,932 | 44 | IMAX | false | false |
| 43 | 38 | Grindhouse | $6,472 | -36.2% | 2 | - | $3,236 | $90,478 | 17 | Roadshow Films | false | false |
| 44 | 35 | Fool's Gold | $5,837 | -47.9% | 16 | -10 | $364 | $4,912,703 | 9 | Warner Bros. | false | false |
| 45 | 45 | Lust, Caution | $4,919 | -23.5% | 8 | - | $614 | $786,983 | 12 | Park Circus | false | false |
| 46 | 53 | Bella | $4,569 | +195% | 6 | -1 | $761 | $174,031 | 7 | Hopscotch Films | false | false |
| 47 | - | Haunted Castle | $4,390 | - | 2 | - | $2,195 | $4,766,380 | 342 | IMAX | false | false |
| 48 | 43 | 27 Dresses | $2,970 | -59.4% | 13 | -3 | $228 | $14,325,769 | 13 | 20th Century Fox International | false | false |
| 49 | - | Shackleton's Antarctic Adventure | $2,792 | - | 1 | - | $2,792 | $3,964,016 | 336 | N/A | false | false |
| 50 | - | Antarctica | $2,115 | - | 1 | - | $2,115 | $3,896,077 | - | IMAX | - | false |
| 51 | 47 | Paranoid Park | $2,023 | -51.3% | 3 | - | $674 | $49,892 | 5 | Madman Entertainment | false | false |
| 52 | 46 | Two Days in Paris | $1,893 | -56.9% | 4 | -1 | $473 | $1,666,986 | 15 | Hopscotch Films | false | false |
| 53 | 54 | 3:10 to Yuma | $1,776 | +69.5% | 10 | +2 | $177 | $2,356,805 | 10 | Hoyts Distribution | false | false |
| 54 | - | Mysteries of Egypt | $1,016 | - | 1 | - | $1,016 | $4,039,302 | - | IMAX | - | false |
| 55 | - | Space Station 3D | $729 | - | 1 | - | $729 | $4,821,805 | 305 | IMAX | false | false |
| 56 | - | Rendition | $394 | - | 3 | - | $131 | $427,417 | 8 | Roadshow Films | false | false |
