| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | 10,000 BC | $224,902 | -27.3% | 34 | - | $6,614 | $651,309 | 2 | Warner Bros. | false | false |
| 2 | - | Horton Hears a Who! | $177,360 | - | 40 | - | $4,434 | $177,360 | 1 | 20th Century Fox International | true | false |
| 3 | - | In the Valley of Elah | $45,629 | - | 15 | - | $3,041 | $45,629 | 1 | Bazuca Films | true | false |
| 4 | 4 | One Missed Call | $36,492 | -18.7% | 17 | -2 | $2,146 | $196,617 | 3 | Warner Bros. | false | false |
| 5 | 6 | No Country for Old Men | $32,421 | -13.4% | 11 | +1 | $2,947 | $311,394 | 5 | United International Pictures | false | false |
| 6 | 2 | American Gangster | $27,729 | -41.8% | 25 | -7 | $1,109 | $206,927 | 3 | United International Pictures | false | false |
| 7 | 9 | Juno | $21,798 | -19.2% | 10 | -1 | $2,179 | $186,533 | 4 | Bazuca Films | false | false |
| 8 | 7 | The Bucket List | $21,258 | -27.2% | 11 | -4 | $1,932 | $478,498 | 7 | Warner Bros. | false | false |
| 9 | 3 | The Water Horse | $20,670 | -54% | 25 | -1 | $826 | $575,078 | 6 | Sony Pictures Releasing | false | false |
| 10 | 10 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | $20,527 | -19.7% | 1 | - | $20,527 | $91,852 | 3 | Walt Disney Pictures | false | false |
| 11 | 8 | P.S. I Love You | $20,447 | -28.8% | 12 | -2 | $1,703 | $263,888 | 5 | Bazuca Films | false | false |
| 12 | 5 | The Game Plan | $18,075 | -52.5% | 19 | -2 | $951 | $969,661 | 9 | Walt Disney Pictures | false | false |
| 13 | 11 | Atonement | $17,477 | -27.1% | 9 | -3 | $1,941 | $229,250 | 5 | United International Pictures | false | false |
| 14 | - | Halloween | $13,029 | - | 11 | - | $1,184 | $13,029 | 1 | Transeuropa | true | false |
| 15 | 12 | There Will Be Blood | $12,756 | -42.2% | 9 | -4 | $1,417 | $163,526 | 4 | Walt Disney Pictures | false | false |
| 16 | 13 | Sweeney Todd: The Demon Barber of Fleet Street | $10,936 | -45.4% | 16 | -1 | $683 | $473,475 | 6 | Warner Bros. | false | false |
| 17 | 16 | The Hitcher | $4,194 | -52% | 3 | -8 | $1,398 | $51,185 | 3 | Bazuca Films | false | false |
| 18 | - | Persepolis | $3,069 | - | 1 | - | $3,069 | $3,069 | 1 | Sony Pictures Releasing | true | false |
| 19 | - | The Education of Fairies | $2,753 | - | 1 | - | $2,753 | $2,753 | 1 | Walt Disney Pictures | true | false |
| 20 | 18 | Cloverfield | $2,715 | -57.2% | 6 | -9 | $452 | $411,278 | 6 | United International Pictures | false | false |
| 21 | 26 | Hannibal Rising | $2,177 | +114.3% | 3 | - | $725 | $85,040 | 7 | United International Pictures | false | false |
| 22 | 15 | Noah's Ark | $2,145 | -82.1% | 8 | -6 | $268 | $91,049 | 4 | Walt Disney Pictures | false | false |
| 23 | 25 | Love in the Time of Cholera | $1,131 | +2.4% | 3 | - | $377 | $368,214 | 9 | 20th Century Fox International | false | false |
| 24 | 14 | 3:10 to Yuma | $1,031 | -92.5% | 3 | -15 | $343 | $19,802 | 2 | Bazuca Films | false | false |
| 25 | 17 | The Kite Runner | $950 | -85.6% | 3 | -2 | $316 | $10,400 | 2 | United International Pictures | false | false |
| 26 | 23 | Enchanted | $505 | -66.1% | 4 | -2 | $126 | $1,425,928 | 14 | Walt Disney Pictures | false | false |
| 27 | 22 | Alvin and the Chipmunks | $498 | -72% | 3 | -3 | $166 | $864,572 | 13 | 20th Century Fox International | false | false |
| 28 | 24 | National Treasure: Book of Secrets | $406 | -67.5% | 4 | +3 | $101 | $1,033,173 | 12 | Walt Disney Pictures | false | false |
| 29 | 21 | Good Luck Chuck | $259 | -92.7% | 1 | -5 | $259 | $98,656 | 5 | Sony Pictures Releasing | false | false |
| 30 | 29 | Gone Baby Gone | $160 | -34.7% | 1 | - | $160 | $30,917 | 8 | Walt Disney Pictures | false | false |
| 31 | 28 | Bridge to Terabithia | $154 | -71.4% | 1 | -2 | $154 | $63,520 | 11 | United International Pictures | false | false |
| 32 | 19 | I Am Legend | $15 | -99.7% | 1 | -9 | $15 | $1,294,576 | 9 | Warner Bros. | false | false |
