| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | The Kite Runner | $467,970 | -7.6% | 77 | - | $6,077 | $3,948,883 | 5 | Universal Pictures International (UPI) | false | false |
| 2 | - | Alvin and the Chipmunks | $401,591 | - | 92 | - | $4,365 | $631,692 | 1 | 20th Century Fox International | true | false |
| 3 | 4 | Nothing to Lose | $228,917 | +7.6% | 38 | +1 | $6,024 | $568,066 | 2 | Independent Films | false | false |
| 4 | - | Sweeney Todd: The Demon Barber of Fleet Street | $226,576 | - | 34 | - | $6,664 | $226,576 | 1 | Warner Bros. | true | false |
| 5 | - | Juno | $222,700 | - | 46 | - | $4,841 | $234,959 | 1 | 20th Century Fox International | true | false |
| 6 | 2 | Cloverfield | $207,166 | -36.7% | 50 | - | $4,143 | $1,374,566 | 3 | Universal Pictures International (UPI) | false | false |
| 7 | - | The Mist | $203,580 | - | 40 | - | $5,089 | $254,833 | 1 | Benelux Film Distributors | true | false |
| 8 | 3 | National Treasure: Book of Secrets | $191,405 | -12.9% | 106 | -4 | $1,805 | $2,418,153 | 5 | Walt Disney Pictures | false | false |
| 9 | 5 | Killer Babes | $162,786 | -9% | 86 | - | $1,892 | $4,544,260 | 8 | Independent Films | false | false |
| 10 | 6 | Charlie Wilson's War | $119,026 | -21% | 40 | - | $2,975 | $373,531 | 2 | Universal Pictures International (UPI) | false | false |
| 11 | 8 | Underdog | $79,822 | +3.4% | 61 | +2 | $1,308 | $222,559 | 2 | Walt Disney Pictures | false | false |
| 12 | 12 | My Brother is an Only Child | $52,069 | -2.1% | 16 | - | $3,254 | $133,927 | 2 | Cinemien | false | false |
| 13 | 10 | Earth | $49,008 | -15.2% | 30 | - | $1,633 | $1,662,578 | 11 | Independent Films | false | false |
| 14 | 7 | I Am Legend | $39,213 | -56.3% | 47 | -27 | $834 | $6,053,468 | 8 | Warner Bros. | false | false |
| 15 | 16 | K3 en de kattenprins | $38,608 | +5.1% | 88 | -5 | $438 | $1,848,957 | 8 | Independent Films | false | false |
| 16 | 9 | Bee Movie | $37,116 | -36.8% | 106 | -2 | $350 | $4,159,347 | 9 | Universal Pictures International (UPI) | false | false |
| 17 | 14 | In the Valley of Elah | $33,093 | -27% | 18 | - | $1,838 | $114,202 | 2 | RCV Film Distribution | false | false |
| 18 | 18 | Atonement | $31,333 | +2.8% | 35 | - | $895 | $1,714,246 | 15 | Universal Pictures International (UPI) | false | false |
| 19 | 11 | Love Is All | $24,095 | -57.3% | 50 | -18 | $481 | $14,332,584 | 18 | A-Film Distribution | false | false |
| 20 | 20 | P.S. I Love You | $23,079 | -9.7% | 17 | -6 | $1,357 | $851,933 | 8 | Independent Films | false | false |
| 21 | - | The Edge of Heaven | $17,924 | - | 11 | - | $1,629 | $17,924 | 1 | A-Film Distribution | true | false |
| 22 | - | Things We Lost in the Fire | $17,511 | - | 9 | - | $1,945 | $17,511 | 1 | Universal Pictures International (UPI) | true | false |
