| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Sorry, If I Love You | $3,909,203 | -42.6% | 508 | +17 | $7,695 | $13,340,870 | 2 | Medusa Distribuzione | false | false |
| 2 | - | Cassandra's Dream | $2,563,186 | - | 360 | - | $7,119 | $2,563,186 | 1 | Filmauro | true | false |
| 3 | - | Cloverfield | $2,273,162 | - | 286 | - | $7,948 | $2,273,162 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 2 | American Gangster | $1,747,974 | -42.1% | 318 | -135 | $5,496 | $12,046,221 | 3 | Universal Pictures International (UPI) | false | false |
| 5 | 5 | Into the Wild | $1,238,577 | +13.2% | 191 | +15 | $6,484 | $2,954,183 | 2 | BIM Distribuzione | false | false |
| 6 | - | P.S. I Love You | $840,504 | - | 250 | - | $3,362 | $840,504 | 1 | 01 Distribution | true | false |
| 7 | 3 | I Am Legend | $814,186 | -55.1% | 207 | -154 | $3,933 | $19,856,000 | 4 | Warner Bros. | false | false |
| 8 | 4 | Alvin and the Chipmunks | $804,495 | -34.4% | 221 | -27 | $3,640 | $4,762,341 | 3 | 20th Century Fox International | false | false |
| 9 | 6 | The Bucket List | $684,315 | -36.5% | 226 | -17 | $3,027 | $2,157,598 | 2 | Warner Bros. | false | false |
| 10 | 10 | Mr. Magorium's Wonder Emporium | $384,569 | -35% | 150 | -10 | $2,563 | $1,150,256 | 2 | Moviemax | false | false |
| 11 | 7 | Black and White | $351,439 | -60.8% | 137 | -125 | $2,565 | $6,957,999 | 4 | 01 Distribution | false | false |
| 12 | 11 | The Secret of the Grain | $248,648 | -25.5% | 70 | -5 | $3,552 | $1,979,878 | 4 | Lucky Red | false | false |
| 13 | 8 | Aliens vs. Predator: Requiem | $215,648 | -69.8% | 139 | -51 | $1,551 | $1,207,140 | 2 | 20th Century Fox International | false | false |
| 14 | 9 | L'allenatore nel pallone 2 | $208,401 | -69% | 75 | -133 | $2,778 | $11,254,222 | 4 | Medusa Distribuzione | false | false |
| 15 | 12 | Caramel | $80,753 | -19.3% | 26 | -6 | $3,105 | $1,733,228 | 7 | Archibald | false | false |
| 16 | 15 | The Savages | $67,663 | +8.3% | 27 | +8 | $2,506 | $166,160 | 2 | 20th Century Fox International | false | false |
| 17 | 34 | The Counterfeiters | $60,960 | +988.8% | 21 | +20 | $2,902 | $71,839 | 2 | Lady Film | false | false |
| 18 | 16 | Irina Palm | $49,148 | -11.3% | 15 | - | $3,276 | $2,212,552 | 9 | Teodora Film | false | false |
| 19 | 13 | Signorina Effe | $45,351 | -45.7% | 14 | -26 | $3,239 | $435,642 | 3 | 01 Distribution | false | false |
| 20 | 14 | Lust, Caution | $38,557 | -51.1% | 16 | -20 | $2,409 | $2,217,103 | 5 | BIM Distribuzione | false | false |
| 21 | - | Piacere Michele Imperatore | $27,794 | - | 9 | - | $3,088 | $27,794 | 1 | Independent Films | true | false |
| 22 | 17 | Lions for Lambs | $25,858 | -48.2% | 16 | -12 | $1,616 | $8,082,648 | 7 | 20th Century Fox International | false | false |
| 23 | 23 | Fracture | $19,644 | -5.3% | 11 | -1 | $1,785 | $3,529,393 | 14 | Eagle Pictures | false | false |
| 24 | 20 | Hotel Meina | $18,211 | -53.2% | 17 | -11 | $1,071 | $87,196 | 2 | Mikado Film | false | false |
| 25 | 24 | Eastern Promises | $17,175 | -5.5% | 8 | - | $2,146 | $4,657,125 | 8 | Eagle Pictures | false | false |
| 26 | 25 | Shelter Me | $16,595 | +12.4% | 7 | -2 | $2,370 | $119,309 | 3 | N/A | false | false |
| 27 | 28 | Bee Movie | $13,014 | +2% | 19 | -8 | $684 | $9,151,066 | 7 | Universal Pictures International (UPI) | false | false |
| 28 | 18 | Love in the Time of Cholera | $12,046 | -72.7% | 7 | -16 | $1,720 | $5,117,518 | 7 | 01 Distribution | false | false |
| 29 | 26 | In the Valley of Elah | $10,838 | -25.6% | 3 | -3 | $3,612 | $2,424,286 | 10 | Mikado Film | false | false |
| 30 | 36 | The Wind Blows Round | $7,661 | +37% | 3 | +1 | $2,553 | $413,723 | 40 | Aranciafilm | false | false |
| 31 | 35 | Across the Universe | $6,590 | +17.8% | 3 | - | $2,196 | $1,055,052 | 11 | Sony Pictures Releasing | false | false |
| 32 | 33 | Lars and the Real Girl | $5,042 | -20.2% | 3 | +1 | $1,680 | $220,011 | 5 | N/A | false | false |
| 33 | 29 | The Golden Compass | $4,793 | -52.3% | 7 | - | $684 | $13,891,095 | 8 | 01 Distribution | false | false |
| 34 | 32 | Alien vs. Predator | $4,716 | -32.9% | 5 | +4 | $943 | $3,885,108 | 168 | 20th Century Fox International | false | false |
| 35 | 27 | Enchanted | $4,574 | -64.2% | 7 | -5 | $653 | $10,154,014 | 9 | Walt Disney Pictures | false | false |
| 36 | - | Conversations with My Gardener | $3,109 | - | 3 | - | $1,036 | $422,659 | 11 | BIM Distribuzione | false | false |
| 37 | - | Elizabeth: The Golden Age | $2,859 | - | 1 | - | $2,859 | $6,622,708 | 15 | Universal Pictures International (UPI) | false | false |
| 38 | - | Il dolce e l'amaro | $2,752 | - | 2 | - | $1,376 | $1,360,482 | 22 | Medusa Distribuzione | false | false |
| 39 | 22 | National Treasure: Book of Secrets | $2,711 | -88.8% | 3 | -11 | $903 | $13,158,643 | 7 | Walt Disney Pictures | false | false |
| 40 | 38 | Lezioni di cioccolato | $2,658 | -25.1% | 1 | -1 | $2,658 | $3,791,147 | 11 | Universal Pictures International (UPI) | false | false |
| 41 | 44 | I Viceré | $2,581 | +50% | 2 | - | $1,290 | $2,372,792 | 13 | 01 Distribution | false | false |
| 42 | - | Everything Is Illuminated | $2,317 | - | 2 | - | $1,158 | $1,123,199 | 117 | Warner Bros. | false | false |
| 43 | 40 | Don't Waste Your Time, Johnny! | $2,271 | -16.7% | 2 | - | $1,135 | $493,242 | 10 | Medusa Distribuzione | false | false |
| 44 | 42 | Days of Darkness | $2,237 | +5.3% | 3 | +1 | $745 | $793,131 | 9 | BIM Distribuzione | false | false |
| 45 | - | My Brother is an Only Child | $1,995 | - | 1 | - | $1,995 | $9,406,247 | 42 | Warner Bros. | false | false |
| 46 | - | Thomas in Love | $1,938 | - | 1 | - | $1,938 | $67,267 | 364 | - | false | false |
| 47 | 43 | Days and Clouds | $1,841 | -13% | 1 | -1 | $1,841 | $5,587,178 | 15 | Warner Bros. | false | false |
| 48 | 30 | Paranoid Park | $1,767 | -82.2% | 2 | -5 | $883 | $934,596 | 9 | Lucky Red | false | false |
| 49 | - | Welcome Back Pinocchio | $1,073 | - | 1 | - | $1,073 | $33,571 | 13 | Moviemax | false | false |
| 50 | 21 | A Beautiful Wife | $1,070 | -96.3% | 2 | -14 | $535 | $29,502,958 | 8 | Medusa Distribuzione | false | false |
