| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 7 | Charlie Wilson's War | $22,027 | +225.4% | 6 | +5 | $3,671 | $39,559 | 2 | N/A | false | false |
| 2 | 1 | Love in the Time of Cholera | $10,993 | -21.1% | 5 | - | $2,198 | $110,380 | 4 | N/A | false | false |
| 3 | 4 | The Game Plan | $10,672 | +17.1% | 7 | +1 | $1,524 | $28,801 | 2 | N/A | false | false |
| 4 | - | Elizabeth: The Golden Age | $9,108 | - | 2 | - | $4,554 | $13,145 | 1 | N/A | true | false |
| 5 | 6 | Alvin and the Chipmunks | $8,801 | +15.3% | 5 | - | $1,760 | $67,980 | 4 | N/A | false | false |
| 6 | 2 | I Am Legend | $7,700 | -38.7% | 5 | - | $1,540 | $112,259 | 4 | N/A | false | false |
| 7 | 3 | American Gangster | $6,153 | -35.8% | 6 | -2 | $1,025 | $67,818 | 3 | N/A | false | false |
| 8 | - | The Seeker: The Dark Is Rising | $5,964 | - | 4 | - | $1,491 | $5,964 | 1 | N/A | true | false |
| 9 | 11 | Michael Clayton | $5,520 | +53.4% | 4 | -1 | $1,380 | $50,572 | 6 | N/A | false | false |
| 10 | 8 | Enchanted | $5,150 | -18.2% | 6 | - | $858 | $97,469 | 6 | N/A | false | false |
| 11 | - | Across the Universe | $4,744 | - | 2 | - | $2,372 | $4,744 | 1 | N/A | true | false |
| 12 | 5 | Aliens vs. Predator: Requiem | $4,334 | -49.4% | 5 | - | $866 | $33,476 | 3 | N/A | false | false |
| 13 | - | Halloween | $2,526 | - | 3 | - | $842 | $2,526 | 1 | N/A | true | false |
| 14 | 9 | Rendition | $2,446 | -54.5% | 4 | - | $611 | $10,840 | 2 | N/A | false | false |
| 15 | 13 | Family Hero | $1,956 | -36.8% | 3 | - | $652 | $12,610 | 2 | N/A | false | false |
| 16 | 12 | The Heartbreak Kid | $1,506 | -57.2% | 2 | -1 | $753 | $63,994 | 6 | N/A | false | false |
| 17 | 10 | The Painted Veil | $1,268 | -69.2% | 2 | -2 | $634 | $21,803 | 3 | N/A | false | false |
| 18 | 14 | The Golden Compass | $592 | -32.7% | 2 | -1 | $296 | $51,934 | 7 | N/A | false | false |
| 19 | 17 | Bee Movie | $551 | +37.4% | 2 | +1 | $275 | $59,702 | 9 | N/A | false | false |
| 20 | 16 | Lights in the Dusk | $455 | -21.6% | 1 | - | $455 | $2,495 | 2 | N/A | false | false |
| 21 | 15 | Superbad | $377 | -45.8% | 1 | -2 | $377 | $39,299 | 8 | N/A | false | false |
| 22 | 18 | Gone Baby Gone | $228 | -3.8% | 1 | - | $228 | $37,217 | 11 | N/A | false | false |
