| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Cloverfield | $404,892 | - | 29 | - | $13,961 | $404,892 | 1 | N/A | true | false |
| 2 | 2 | American Gangster | $118,327 | -34.1% | 24 | - | $4,930 | $402,938 | 2 | N/A | false | false |
| 3 | 1 | One Missed Call | $63,963 | -66% | 26 | - | $2,460 | $290,329 | 2 | N/A | false | false |
| 4 | 4 | Body | $45,856 | -55.2% | 18 | - | $2,547 | $226,266 | 2 | N/A | false | false |
| 5 | 5 | Le Grand Chef | $45,132 | -47.3% | 15 | - | $3,008 | $177,450 | 2 | N/A | false | false |
| 6 | 3 | Aliens vs. Predator: Requiem | $36,919 | -74.4% | 24 | -26 | $1,538 | $1,307,799 | 3 | N/A | false | false |
| 7 | 7 | Dan in Real Life | $24,275 | -50.7% | 11 | - | $2,206 | $102,331 | 2 | N/A | false | false |
| 8 | 6 | I Am Legend | $18,319 | -75.4% | 31 | - | $590 | $2,159,330 | 4 | N/A | false | false |
| 9 | 8 | National Treasure: Book of Secrets | $12,647 | -71.3% | 12 | -12 | $1,053 | $2,183,876 | 5 | N/A | false | false |
| 10 | - | 3:10 to Yuma | $11,107 | - | 4 | - | $2,776 | $13,835 | 1 | N/A | true | false |
| 11 | - | The Savages | $10,130 | - | 3 | - | $3,376 | $10,130 | 1 | N/A | true | false |
| 12 | - | The Flock | $9,777 | - | 4 | - | $2,444 | $9,777 | 1 | N/A | true | false |
| 13 | 10 | Michael Clayton | $9,561 | -56.1% | 5 | - | $1,912 | $90,156 | 3 | N/A | false | false |
| 14 | 9 | Eastern Promises | $7,038 | -68.6% | 5 | -1 | $1,407 | $94,020 | 3 | N/A | false | false |
| 15 | 11 | Alvin and the Chipmunks | $6,304 | -65.5% | 6 | -7 | $1,050 | $1,978,952 | 6 | N/A | false | false |
| 16 | 13 | The Darjeeling Limited | $4,848 | -70% | 3 | -1 | $1,616 | $63,237 | 3 | N/A | false | false |
| 17 | - | Sharkwater | $4,650 | - | 3 | - | $1,550 | $7,917 | 1 | N/A | true | false |
| 18 | 12 | Linger | $4,158 | -76.5% | 3 | -5 | $1,386 | $27,824 | 2 | N/A | false | false |
| 19 | 16 | Trade | $4,088 | -35.7% | 1 | - | $4,088 | $12,471 | 2 | N/A | false | false |
| 20 | 15 | Love in the Time of Cholera | $3,949 | -39.8% | 3 | - | $1,316 | $13,037 | 2 | N/A | false | false |
| 21 | 18 | My Blueberry Nights | $2,264 | -58.2% | 3 | - | $754 | $62,202 | 4 | N/A | false | false |
| 22 | 20 | Elizabeth: The Golden Age | $1,369 | -68.2% | 3 | -4 | $456 | $117,800 | 4 | N/A | false | false |
| 23 | 14 | Vexille | $803 | -88.4% | 1 | - | $803 | $31,462 | 4 | N/A | false | false |
| 24 | 26 | Lust, Caution | $795 | -37.2% | 1 | - | $795 | $1,121,239 | 16 | N/A | false | false |
| 25 | 24 | Nanking | $674 | -52.2% | 1 | - | $674 | $67,581 | 7 | N/A | false | false |
| 26 | 19 | Boogeyman 2 | $497 | -89.9% | 1 | -1 | $497 | $23,309 | 3 | N/A | false | false |
| 27 | 17 | The Warlords | $410 | -93.2% | 2 | -8 | $205 | $1,557,155 | 6 | N/A | false | false |
| 28 | 23 | Enchanted | $199 | -85.9% | 1 | -2 | $199 | $2,086,680 | 9 | N/A | false | false |
| 29 | 25 | Reservation Road | $92 | -93.4% | 1 | -2 | $92 | $7,563 | 3 | N/A | false | false |
| 30 | 22 | Penny Dreadful | $73 | -96.5% | 4 | -3 | $18 | $17,304 | 3 | N/A | false | false |
