| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | I Am Legend | $312,762 | - | 38 | - | $8,230 | $312,762 | 1 | Warner Bros. | true | false |
| 2 | 1 | Enchanted | $78,042 | -27.1% | 32 | -3 | $2,438 | $971,918 | 6 | Walt Disney Pictures | false | false |
| 3 | - | The Game Plan | $77,239 | - | 21 | - | $3,678 | $77,239 | 1 | Walt Disney Pictures | true | false |
| 4 | 2 | National Treasure: Book of Secrets | $70,049 | -31.2% | 36 | -6 | $1,945 | $680,430 | 4 | Walt Disney Pictures | false | false |
| 5 | - | Love in the Time of Cholera | $69,083 | - | 27 | - | $2,558 | $69,083 | 1 | 20th Century Fox International | true | false |
| 6 | 3 | Alvin and the Chipmunks | $53,931 | -22.6% | 32 | -2 | $1,685 | $577,368 | 5 | 20th Century Fox International | false | false |
| 7 | 4 | Chile puede | $29,774 | -51.8% | 32 | -8 | $930 | $297,246 | 3 | Warner Bros. | false | false |
| 8 | 5 | The Golden Compass | $21,900 | -51.9% | 17 | -14 | $1,288 | $714,526 | 6 | Warner Bros. | false | false |
| 9 | 6 | The Heartbreak Kid | $16,797 | -58.6% | 12 | -13 | $1,399 | $391,603 | 5 | United International Pictures | false | false |
| 10 | 8 | 30 Days of Night | $15,060 | -52% | 16 | - | $941 | $65,808 | 2 | Sony Pictures Releasing | false | false |
| 11 | 7 | Hitman | $12,734 | -66.2% | 17 | -2 | $749 | $74,098 | 2 | 20th Century Fox International | false | false |
| 12 | - | Venus | $12,206 | - | 6 | - | $2,034 | $12,206 | 1 | Transeuropa | true | false |
| 13 | 12 | Priceless | $7,236 | -51.7% | 7 | - | $1,033 | $29,772 | 2 | Transeuropa | false | false |
| 14 | 9 | Shattered | $6,862 | -71.2% | 13 | -6 | $527 | $44,279 | 2 | Bazuca Films | false | false |
| 15 | 16 | Beowulf | $6,659 | +9.7% | 3 | - | $2,219 | $603,875 | 9 | Warner Bros. | false | false |
| 16 | 11 | Bee Movie | $5,916 | -60.6% | 8 | -13 | $739 | $621,234 | 7 | United International Pictures | false | false |
| 17 | 10 | 1408 | $5,772 | -67% | 5 | -8 | $1,154 | $139,391 | 4 | United International Pictures | false | false |
| 18 | 13 | Pulentos, la película | $4,436 | -57.5% | 9 | -6 | $492 | $127,507 | 4 | Bazuca Films | false | false |
| 19 | 14 | Michael Clayton | $4,304 | -43.7% | 2 | -3 | $2,152 | $136,459 | 7 | Bazuca Films | false | false |
| 20 | 17 | Sleuth | $3,886 | -32.7% | 1 | - | $3,886 | $11,123 | 2 | Sony Pictures Releasing | false | false |
| 21 | - | Underdog | $820 | - | 2 | - | $410 | $496,714 | 13 | Walt Disney Pictures | false | false |
| 22 | 18 | Saw IV | $625 | -87.5% | 2 | -6 | $312 | $269,072 | 7 | Walt Disney Pictures | false | false |
| 23 | 15 | Bridge to Terabithia | $163 | -97.6% | 1 | -8 | $163 | $42,595 | 3 | United International Pictures | false | false |
