| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | National Treasure: Book of Secrets | $422,493 | - | 90 | - | $4,694 | $422,493 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Enchanted | $278,233 | -30.6% | 93 | +4 | $2,991 | $1,734,546 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | I Am Legend | $210,856 | -34.1% | 79 | +4 | $2,669 | $1,502,628 | 4 | Warner Bros. | false | false |
| 4 | - | Love in the Time of Cholera | $103,050 | - | 33 | - | $3,122 | $103,050 | 1 | 20th Century Fox International | true | false |
| 5 | 3 | Aliens vs. Predator: Requiem | $92,305 | -43.3% | 40 | -1 | $2,307 | $323,191 | 2 | 20th Century Fox International | false | false |
| 6 | 4 | American Gangster | $89,070 | -32.1% | 54 | +3 | $1,649 | $529,735 | 3 | United International Pictures | false | false |
| 7 | 5 | Alvin and the Chipmunks | $68,153 | -30.9% | 62 | -1 | $1,099 | $421,049 | 3 | 20th Century Fox International | false | false |
| 8 | 6 | The Golden Compass | $46,127 | -49.9% | 80 | -4 | $576 | $1,284,673 | 6 | Distribution Company | false | false |
| 9 | 7 | I Could Never Be Your Woman | $36,228 | -37.1% | 29 | -5 | $1,249 | $229,657 | 3 | CDI Films | false | false |
| 10 | - | Giants of Valdes | $32,647 | - | 33 | - | $989 | $32,647 | 1 | Primer Plano Film Group | true | false |
| 11 | 11 | The Heartbreak Kid | $27,968 | -21.5% | 29 | -4 | $964 | $792,984 | 11 | United International Pictures | false | false |
| 12 | 8 | Sleuth | $27,690 | -41.6% | 11 | - | $2,517 | $93,708 | 2 | Sony Pictures Releasing | false | false |
| 13 | - | Bordertown | $26,852 | - | 32 | - | $839 | $26,852 | 1 | Distribution Company | true | false |
| 14 | 9 | Bridge to Terabithia | $12,704 | -70.1% | 30 | -6 | $423 | $80,148 | 2 | United International Pictures | false | false |
| 15 | 12 | Bee Movie | $12,369 | -61.3% | 41 | -36 | $301 | $1,441,716 | 7 | United International Pictures | false | false |
| 16 | 13 | My Best Friend | $12,336 | -40.7% | 10 | -5 | $1,233 | $90,679 | 3 | Alfa Films | false | false |
| 17 | 14 | Gone Baby Gone | $9,465 | -26% | 9 | -9 | $1,051 | $345,472 | 9 | Walt Disney Pictures | false | false |
| 18 | 10 | August Rush | $6,017 | -83.9% | 12 | -30 | $501 | $63,654 | 2 | Distribution Company | false | false |
| 19 | 17 | 4 Months, 3 Weeks and 2 Days | $4,590 | -24.1% | 6 | -5 | $765 | $179,769 | 7 | Pachamama Cine | false | false |
| 20 | 16 | The Flock | $4,224 | -55.4% | 15 | -8 | $281 | $182,721 | 7 | CDI Films | false | false |
| 21 | 21 | Café Lumière 2007 Re-release | $3,286 | -0.3% | 2 | - | $1,643 | $41,720 | 6 | 791 Cine | false | false |
| 22 | 15 | Beowulf | $3,119 | -68.9% | 21 | -18 | $148 | $697,946 | 9 | Warner Bros. | false | false |
| 23 | 24 | The Hitcher | $2,867 | +3.9% | 6 | -3 | $477 | $133,728 | 7 | Distribution Company | false | false |
| 24 | 29 | Retribution | $2,472 | +83.8% | 4 | -1 | $618 | $111,961 | 6 | Pachamama Cine | false | false |
| 25 | 23 | Suspiros del corazón | $1,917 | -30.6% | 4 | - | $479 | $5,833 | 2 | Primer Plano Film Group | false | false |
| 26 | 19 | Days of Glory | $1,678 | -59.9% | 3 | -2 | $559 | $17,454 | 3 | Alfa Films | false | false |
| 27 | 22 | After the Wedding | $1,470 | -55.4% | 3 | -4 | $490 | $103,829 | 9 | Alfa Films | false | false |
| 28 | 32 | Hechos, No Palabras | $1,193 | +136.2% | 1 | - | $1,193 | $2,048 | 2 | Primer Plano Film Group | false | false |
| 29 | 27 | Saw IV | $996 | -56.1% | 4 | -11 | $249 | $1,013,333 | 12 | Walt Disney Pictures | false | false |
| 30 | - | Open Season | $935 | - | 1 | - | $935 | $551,641 | 68 | Sony Pictures Releasing | false | false |
| 31 | 20 | The Assassination of Jesse James by the Coward Robert Ford | $922 | -73.2% | 8 | -1 | $115 | $145,060 | 8 | Warner Bros. | false | false |
| 32 | 18 | Lions for Lambs | $901 | -79.4% | 9 | -16 | $100 | $502,424 | 10 | 20th Century Fox International | false | false |
| 33 | 25 | The Black Dahlia | $738 | -72% | 1 | -1 | $738 | $61,912 | 9 | United International Pictures | false | false |
| 34 | 44 | Shortbus | $604 | +158.1% | 2 | +1 | $302 | $29,324 | 12 | Distribution Company | false | false |
| 35 | 28 | Superbad | $483 | -78.7% | 6 | -8 | $80 | $393,310 | 9 | Sony Pictures Releasing | false | false |
| 36 | 31 | Whisper | $334 | -39.4% | 1 | -1 | $334 | $110,979 | 8 | Alfa Films | false | false |
| 37 | 40 | Estrellas | $264 | -15.4% | 1 | - | $264 | $14,248 | 6 | Primer Plano Film Group | false | false |
| 38 | 41 | Sicko | $261 | -6.5% | 1 | - | $261 | $67,648 | 18 | Alfa Films | false | false |
| 39 | 54 | Lights in the Dusk | $234 | +485% | 1 | - | $234 | $51,118 | 17 | Alfa Films | false | false |
| 40 | 30 | Shattered | $232 | -62.2% | 4 | -2 | $58 | $325,424 | 11 | Distribution Company | false | false |
| 41 | - | 12:08 East of Bucharest | $227 | - | 1 | - | $227 | $87,423 | 38 | Zeta Films | false | false |
| 42 | 42 | Encarnacion | $217 | -13.2% | 2 | +1 | $108 | $40,227 | 15 | Distribution Company | false | false |
| 43 | 55 | Michael Clayton | $208 | +433.3% | 1 | -2 | $208 | $559,137 | 15 | Alfa Films | false | false |
| 44 | - | Family Hero | $190 | - | 1 | - | $190 | $190,119 | 17 | Pachamama Cine | false | false |
| 45 | - | The Death of Mr. Lazarescu | $137 | - | 1 | - | $137 | $23,008 | 55 | Zeta Films | false | false |
| 46 | 43 | Quiéreme | $124 | -49.6% | 1 | -2 | $124 | $62,455 | 10 | Alfa Films | false | false |
| 47 | 53 | Fierro | $83 | +97.6% | 2 | +1 | $41 | $154,909 | 11 | Primer Plano Film Group | false | false |
| 48 | 34 | Underdog | $81 | -81.6% | 2 | -10 | $40 | $850,283 | 16 | Walt Disney Pictures | false | false |
| 49 | - | Ratatouille | $55 | - | 1 | - | $55 | $3,860,168 | 29 | Buena Vista International | false | false |
| 50 | 56 | The Simpsons Movie | $53 | +82.8% | 2 | -1 | $26 | $7,562,798 | 26 | 20th Century Fox International | false | false |
| 51 | 48 | Black Book | $46 | -53.5% | 1 | - | $46 | $471,153 | 22 | Pachamama Cine | false | false |
| 52 | - | Premonition | $42 | - | 1 | - | $42 | $537,519 | 20 | Distribution Company | false | false |
| 53 | 49 | Vitus | $38 | -45.7% | 1 | - | $38 | $48,360 | 10 | CDI Films | false | false |
| 54 | - | The Past | $17 | - | 1 | - | $17 | $61,970 | 11 | 20th Century Fox International | false | false |
| 55 | 37 | The Painted Veil | $11 | -97.3% | 1 | -2 | $11 | $364,235 | 16 | Distribution Company | false | false |
