| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | One Missed Call | $188,047 | - | 26 | - | $7,232 | $188,047 | 1 | N/A | true | false |
| 2 | - | American Gangster | $179,470 | - | 24 | - | $7,477 | $237,430 | 1 | N/A | true | false |
| 3 | 1 | Aliens vs. Predator: Requiem | $143,964 | -65% | 50 | -1 | $2,879 | $1,228,262 | 2 | N/A | false | false |
| 4 | - | Body | $102,324 | - | 18 | - | $5,684 | $150,796 | 1 | N/A | true | false |
| 5 | - | Le Grand Chef | $85,702 | - | 15 | - | $5,713 | $109,643 | 1 | N/A | true | false |
| 6 | 2 | I Am Legend | $74,358 | -65.7% | 31 | -11 | $2,398 | $2,125,506 | 3 | N/A | false | false |
| 7 | - | Dan in Real Life | $49,277 | - | 11 | - | $4,479 | $65,246 | 1 | N/A | true | false |
| 8 | 3 | National Treasure: Book of Secrets | $44,118 | -63.6% | 24 | -10 | $1,838 | $2,160,449 | 4 | N/A | false | false |
| 9 | 5 | Eastern Promises | $22,386 | -43.7% | 6 | - | $3,731 | $81,480 | 2 | N/A | false | false |
| 10 | 6 | Michael Clayton | $21,774 | -35.8% | 5 | - | $4,354 | $75,467 | 2 | N/A | false | false |
| 11 | 4 | Alvin and the Chipmunks | $18,256 | -69.5% | 13 | -10 | $1,404 | $1,969,076 | 5 | N/A | false | false |
| 12 | - | Linger | $17,672 | - | 8 | - | $2,209 | $18,793 | 1 | N/A | true | false |
| 13 | 8 | The Darjeeling Limited | $16,165 | -42.3% | 4 | - | $4,041 | $52,765 | 2 | N/A | false | false |
| 14 | 15 | Vexille | $6,901 | -6.1% | 1 | - | $6,901 | $29,076 | 3 | N/A | false | false |
| 15 | - | Love in the Time of Cholera | $6,560 | - | 3 | - | $2,186 | $7,303 | 1 | N/A | true | false |
| 16 | - | Trade | $6,358 | - | 1 | - | $6,358 | $6,358 | 1 | N/A | true | false |
| 17 | 7 | The Warlords | $5,992 | -80.7% | 10 | -10 | $599 | $1,554,838 | 5 | N/A | false | false |
| 18 | 11 | My Blueberry Nights | $5,417 | -54.3% | 3 | -1 | $1,805 | $58,478 | 3 | N/A | false | false |
| 19 | 10 | Boogeyman 2 | $4,916 | -59.7% | 2 | - | $2,458 | $21,820 | 2 | N/A | false | false |
| 20 | 9 | Elizabeth: The Golden Age | $4,303 | -80.2% | 7 | -2 | $614 | $114,859 | 3 | N/A | false | false |
| 21 | 12 | Across the Universe | $3,510 | -66.8% | 2 | -1 | $1,755 | $53,702 | 3 | N/A | false | false |
| 22 | 13 | Penny Dreadful | $2,057 | -79.7% | 7 | -4 | $293 | $16,732 | 2 | N/A | false | false |
| 23 | 19 | Enchanted | $1,414 | -44.2% | 3 | -1 | $471 | $2,086,088 | 8 | N/A | false | false |
| 24 | 18 | Nanking | $1,409 | -48.3% | 1 | - | $1,409 | $66,143 | 6 | N/A | false | false |
| 25 | 16 | Reservation Road | $1,394 | -64.7% | 3 | - | $464 | $6,993 | 2 | N/A | false | false |
| 26 | 14 | Lust, Caution | $1,265 | -85.7% | 1 | -4 | $1,265 | $1,119,983 | 15 | N/A | false | false |
| 27 | 21 | Redline | $290 | -85.6% | 2 | -6 | $145 | $92,685 | 4 | N/A | false | false |
