| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Aliens vs. Predator: Requiem | $411,745 | - | 51 | - | $8,073 | $994,395 | 1 | N/A | true | false |
| 2 | 1 | I Am Legend | $216,560 | -69.2% | 42 | -11 | $5,156 | $1,998,529 | 2 | N/A | false | false |
| 3 | 2 | National Treasure: Book of Secrets | $121,052 | -68.1% | 34 | -19 | $3,560 | $2,077,624 | 3 | N/A | false | false |
| 4 | 3 | Alvin and the Chipmunks | $59,953 | -74.5% | 23 | -3 | $2,606 | $1,931,767 | 4 | N/A | false | false |
| 5 | - | Eastern Promises | $39,749 | - | 6 | - | $6,624 | $46,693 | 1 | N/A | true | false |
| 6 | - | Michael Clayton | $33,907 | - | 5 | - | $6,781 | $44,420 | 1 | N/A | true | false |
| 7 | 4 | The Warlords | $31,031 | -74.3% | 20 | -9 | $1,551 | $1,536,717 | 4 | N/A | false | false |
| 8 | - | The Darjeeling Limited | $28,027 | - | 4 | - | $7,006 | $28,027 | 1 | N/A | true | false |
| 9 | 5 | Elizabeth: The Golden Age | $21,692 | -48.5% | 9 | - | $2,410 | $104,086 | 2 | N/A | false | false |
| 10 | - | Boogeyman 2 | $12,210 | - | 2 | - | $6,105 | $12,210 | 1 | N/A | true | false |
| 11 | 7 | My Blueberry Nights | $11,863 | -52.9% | 4 | - | $2,965 | $48,326 | 2 | N/A | false | false |
| 12 | 9 | Across the Universe | $10,566 | -41.9% | 3 | - | $3,522 | $46,061 | 2 | N/A | false | false |
| 13 | - | Penny Dreadful | $10,120 | - | 11 | - | $920 | $10,120 | 1 | N/A | true | false |
| 14 | 8 | Lust, Caution | $8,832 | -54.7% | 5 | - | $1,766 | $1,115,289 | 14 | N/A | false | false |
| 15 | 12 | Vexille | $7,347 | -17.2% | 1 | - | $7,347 | $20,985 | 2 | N/A | false | false |
| 16 | - | Reservation Road | $3,948 | - | 3 | - | $1,316 | $3,948 | 1 | N/A | true | false |
| 17 | 6 | The Golden Compass | $2,918 | -88.4% | 5 | -14 | $583 | $1,993,950 | 5 | N/A | false | false |
| 18 | 16 | Nanking | $2,727 | -47.5% | 1 | - | $2,727 | $63,530 | 5 | N/A | false | false |
| 19 | 13 | Enchanted | $2,535 | -70.3% | 4 | -3 | $633 | $2,083,965 | 7 | N/A | false | false |
| 20 | 11 | Mr. Magorium's Wonder Emporium | $2,261 | -80.9% | 2 | -6 | $1,130 | $302,923 | 4 | N/A | false | false |
| 21 | 10 | Redline | $2,016 | -88.8% | 8 | -3 | $252 | $91,944 | 3 | N/A | false | false |
