| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | National Treasure: Book of Secrets | $123,862 | -24.4% | 43 | +1 | $2,880 | $390,872 | 2 | Walt Disney Pictures | false | false |
| 2 | 2 | Enchanted | $117,602 | -17% | 35 | -2 | $3,360 | $644,838 | 4 | Walt Disney Pictures | false | false |
| 3 | - | Chile puede | $99,345 | - | 40 | - | $2,483 | $99,345 | 1 | Warner Bros. | true | false |
| 4 | 4 | Alvin and the Chipmunks | $81,751 | -24.6% | 33 | -2 | $2,477 | $341,020 | 3 | 20th Century Fox International | false | false |
| 5 | 3 | The Golden Compass | $60,159 | -48.2% | 38 | -12 | $1,583 | $563,744 | 4 | Warner Bros. | false | false |
| 6 | 5 | The Heartbreak Kid | $58,311 | -38.9% | 27 | -1 | $2,159 | $268,524 | 3 | United International Pictures | false | false |
| 7 | 7 | 1408 | $30,198 | -40.4% | 20 | +6 | $1,509 | $88,979 | 2 | United International Pictures | false | false |
| 8 | 6 | Bee Movie | $24,581 | -67.6% | 29 | -28 | $847 | $569,709 | 5 | United International Pictures | false | false |
| 9 | - | Bridge to Terabithia | $18,669 | - | 14 | - | $1,333 | $18,669 | 1 | United International Pictures | true | false |
| 10 | 8 | Pulentos, la película | $17,988 | -60.6% | 26 | -12 | $691 | $85,627 | 2 | Bazuca Films | false | false |
| 11 | 9 | Saw IV | $14,895 | -45% | 13 | -5 | $1,145 | $250,650 | 5 | Walt Disney Pictures | false | false |
| 12 | 11 | Michael Clayton | $9,868 | -37.1% | 4 | -3 | $2,467 | $117,520 | 5 | Bazuca Films | false | false |
| 13 | 12 | Beowulf | $9,017 | -42.1% | 3 | +2 | $3,005 | $585,797 | 7 | Warner Bros. | false | false |
| 14 | - | Stormbreaker | $7,635 | - | 8 | - | $954 | $7,635 | 1 | Impacto Cine | true | false |
| 15 | 10 | The Assassination of Jesse James by the Coward Robert Ford | $7,268 | -63.9% | 6 | -4 | $1,211 | $32,953 | 2 | Warner Bros. | false | false |
| 16 | 14 | Knocked Up | $2,022 | -40.1% | 1 | - | $2,022 | $132,254 | 8 | United International Pictures | false | false |
| 17 | 15 | Resident Evil: Extinction | $836 | -72.1% | 1 | -4 | $836 | $390,108 | 10 | Sony Pictures Releasing | false | false |
| 18 | 13 | Che Kopete: La película | $823 | -84.9% | 3 | -7 | $274 | $854,243 | 8 | - | false | false |
| 19 | 17 | Orchestra Seats | $511 | -29.2% | 1 | - | $511 | $68,693 | 9 | Transeuropa | false | false |
| 20 | 16 | I Now Pronounce You Chuck & Larry | $321 | -80.7% | 1 | -3 | $321 | $107,217 | 7 | United International Pictures | false | false |
| 21 | 19 | Next | $273 | -16% | 1 | - | $273 | $110,075 | 9 | United International Pictures | false | false |
| 22 | 18 | Underdog | $190 | -70.5% | 1 | -2 | $190 | $474,793 | 11 | Walt Disney Pictures | false | false |
