| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | American Gangster | $271,720 | -44.5% | 57 | -1 | $4,767 | $1,389,596 | 3 | Universal Pictures International (UPI) | false | false |
| 2 | - | Enchanted | $141,991 | - | 21 | - | $6,761 | $153,455 | 1 | Walt Disney Pictures | true | false |
| 3 | 2 | Ratatouille | $135,019 | -41.7% | 78 | -6 | $1,731 | $7,797,115 | 18 | Walt Disney Pictures | false | false |
| 4 | 3 | Beowulf | $108,213 | -53.2% | 53 | -23 | $2,041 | $544,893 | 3 | Warner Bros. | false | false |
| 5 | 4 | The Heartbreak Kid | $105,376 | -40.9% | 43 | -9 | $2,450 | $1,255,273 | 5 | Universal Pictures International (UPI) | false | false |
| 6 | 5 | Lions for Lambs | $91,209 | -46.1% | 37 | - | $2,465 | $594,059 | 4 | 20th Century Fox International | false | false |
| 7 | - | Resident Evil: Extinction | $65,830 | - | 13 | - | $5,063 | $66,620 | 1 | Rialto Distribution | true | false |
| 8 | 7 | Atonement | $57,259 | -33.2% | 20 | +3 | $2,862 | $491,782 | 4 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Earth | $54,405 | -42.3% | 31 | -1 | $1,755 | $865,666 | 8 | Frenetic Films | false | false |
| 10 | - | Gone Baby Gone | $49,908 | - | 11 | - | $4,537 | $49,908 | 1 | Walt Disney Pictures | true | false |
| 11 | 10 | The Three Investigators and the Secret of Skeleton Island | $45,794 | -37.7% | 59 | - | $776 | $343,660 | 4 | Walt Disney Pictures | false | false |
| 12 | 9 | I Now Pronounce You Chuck & Larry | $41,980 | -43.4% | 21 | - | $1,999 | $1,053,979 | 14 | Universal Pictures International (UPI) | false | false |
| 13 | - | Michael Clayton | $38,772 | - | 11 | - | $3,524 | $73,491 | 9 | Rialto Distribution | false | false |
| 14 | 8 | Rendition | $38,731 | -49.3% | 18 | - | $2,151 | $119,362 | 2 | Warner Bros. | false | false |
| 15 | 11 | Saw IV | $34,862 | -27.7% | 6 | - | $5,810 | $91,102 | 2 | Ascot Elite Entertainment Group | false | false |
| 16 | - | Free Rainer | $30,595 | - | 8 | - | $3,824 | $30,595 | 1 | Pathé | true | false |
| 17 | - | Messy Christmas | $30,569 | - | 13 | - | $2,351 | $30,569 | 1 | Filmcoopi | true | false |
| 18 | - | We Own the Night | $25,348 | - | 7 | - | $3,621 | $28,017 | 1 | Universal Pictures International (UPI) | true | false |
| 19 | - | Fred Claus | $23,822 | - | 14 | - | $1,701 | $23,822 | 1 | Warner Bros. | true | false |
| 20 | - | My Blueberry Nights | $23,733 | - | 4 | - | $5,933 | $28,107 | 1 | Frenetic Films | true | false |
